Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michael L. Coen"'
Autor:
Amir E. Wahba, Pier Paolo Claudio, Mahesh Kumar Gundluru, David A. Lewis, James D. McChesney, Douglas L. Rodenburg, Michael L. Coen, Igor Nikoulin, Patrice Penfornis, Steve J. Bannister
Veiled Therapeutics has developed an anticancer technology, TumorSelect® Technology, which combines proprietary anticancer prodrugs and nanotechnology, which takes advantage from current knowledge of human physiology. Tumors have a voracious appetit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::399a1fdf86d4b8ca95ce68cbfd612f94
https://doi.org/10.21203/rs.3.rs-701601/v1
https://doi.org/10.21203/rs.3.rs-701601/v1
Autor:
Cele Abad-Zapatero, Yong Jia, David J. Burns, Timothy E. Cloutier, Zhili Xin, Douglas Marcotte, Hua Tang, Kenneth M. Comess, Teresa I. Ng, David W. Borhani, Michael L. Coen, Sanyi Wang, Harriet T. Smith, Eric R. Goedken, Danying Song, Jill E. Clampit, Bo Liu, Philip J. Hajduk, Xueheng Cheng, Maria A. Argiriadi, David Banach, Chaohong Sun, Duncan R. Groebe, Elizabeth H. Fry, Christopher Quinn, Gang Liu, David J. Calderwood, Deanna L. Haasch, Vincent S. Stoll, Rebecca J. Gum
Publikováno v:
ACS Chemical Biology. 6:234-244
Inhibition of protein kinases has validated therapeutic utility for cancer, with at least seven kinase inhibitor drugs on the market. Protein kinase inhibition also has significant potential for a variety of other diseases, including diabetes, pain,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24a8e4dd5ebafebd0f1d8db41a15f68
https://doi.org/10.1021/cb1002619
https://doi.org/10.1021/cb1002619
Autor:
Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik
Publikováno v:
Chemical Biology & Drug Design. 69:395-404
As part of a fully integrated and comprehensive strategy to discover novel antibacterial agents, NMR- and mass spectrometry-based affinity selection screens were performed to identify compounds that bind to protein targets uniquely found in bacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5518c2506c2d9a00a67d68a32abac6
https://doi.org/10.1111/j.1747-0285.2007.00521.x
https://doi.org/10.1111/j.1747-0285.2007.00521.x
Autor:
Ping Zhong, Philip J. Hajduk, Rachel Hammond, Vicki L. Nienaber, Bruce A. Beutel, David J. Augeri, Michael L. Coen, David A. Janowick, Jeffrey M. Schkeryantz, Jürgen Dinges, Kaminski Michele A, Stephen W. Fesik, Leonard Katz, Michael D. Tufano, Andrew M. Petros
Publikováno v:
Journal of Medicinal Chemistry. 42:3852-3859
The Erm family of methyltransferases confers resistance to the macrolide-lincosamide-streptogramin type B (MLS) antibiotics through the methylation of 23S ribosomal RNA. Upon the methylation of RNA, the MLS antibiotics lose their ability to bind to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9e0becf8b17684daca10ca69abd125
https://doi.org/10.1021/jm990293a
https://doi.org/10.1021/jm990293a
Autor:
Robert C. Goldman, Jonathan A. Meulbroek, Thomas McGonigal, Michael L. Coen, Aparna V. Sarthy, David Frost
Publikováno v:
Microbiology. 143:367-376
The BGL2 gene encodes a unique 1,3-β-glucosyltransferase (BgI2p) present in the cell wall of Candida albicans and other fungi. Although believed to be involved in cell wall assembly, disruption of the gene in Saccharomyces cerevisiae showed no appar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa7b02fdf280b49002bff57278da179
https://doi.org/10.1099/00221287-143-2-367
https://doi.org/10.1099/00221287-143-2-367
Autor:
Mark E, Cohen, Jennifer A, Harte, Mark E, Stone, Karen H, O'Connor, Michael L, Coen, Malford E, Cullum
Publikováno v:
The Journal of clinical dentistry. 18(2)
While it is important to monitor dental water quality, it is unclear whether in-office test kits provide bacterial counts comparable to the gold standard method (R2A). Studies were conducted on specimens with known bacterial concentrations, and from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::873f706b6066f02e4686d290ccb658ea
https://pubmed.ncbi.nlm.nih.gov/17508622
https://pubmed.ncbi.nlm.nih.gov/17508622
Autor:
Mark E. Schurdak, Lan Gao, Claude G. Lerner, Houjun Yang, Jonathan D. Trumbull, Hua Tang, David J. Burns, Xueheng Cheng, Bruce A. Beutel, J. Owen McCall, Michael L. Coen, Kenneth M. Comess, Martin J. Voorbach
Publikováno v:
Journal of biomolecular screening. 11(7)
The authors describe the discovery of a new class of inhibitors to an essential Streptococcus pneumoniae cell wall biosynthesis enzyme, MurF, by a novel affinity screening method. The strategy involved screening very large mixtures of diverse small o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bb69a48eb3022e567651e240c43c5e
https://pubmed.ncbi.nlm.nih.gov/16973923
https://pubmed.ncbi.nlm.nih.gov/16973923
Autor:
Shi-Chung Ng, Jie Qian, Haichao Zhang, Kenneth M. Comess, Michael L. Coen, Andrew M. Petros, Jeffrey R. Huth, Martin J. Voorbach, Saul H. Rosenberg, David J. Burns, Usha Warrior
Publikováno v:
Analytical biochemistry. 328(2)
Bcl-xL is a member of the Bcl-2 family of proteins that are implicated to play a vital role in several diseases including cancer. Bcl-xL suppresses apoptosis; thus the inhibition of Bcl-xL function could restore the apoptotic process. To identify ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d159ff176b392644963056bfe15905c
https://pubmed.ncbi.nlm.nih.gov/15113688
https://pubmed.ncbi.nlm.nih.gov/15113688
Publikováno v:
Microbiology (Reading, England). 140
The synthesis and metabolism of yeast cell wall glucan were studied using a Saccharomyces cerevisiae construct in which radiolabelled galactose is metabolized to UDP-glucose and preferentially incorporated into glucan. Greater than 85% of the incorpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f6721c351b9455475634f60d8a9ffd
https://pubmed.ncbi.nlm.nih.gov/7952174
https://pubmed.ncbi.nlm.nih.gov/7952174