Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Michael L Steer"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 4, Pp 519-535 (2016)
Background & Aims: Severe acute pancreatitis is characterized by acinar cell death and inflammation. Necroptosis is an aggressive and proinflammatory mode of cell death that can be prevented by necrostatin-1 administration or receptor-interacting pro
Externí odkaz:
https://doaj.org/article/65bb2d8c902840dbbe6e7c930b6c1e29
Autor:
Emile Rwamasirabo, Sarah Maongezi, Michael L. Steer, Mzaza Nthele, Swagoto Mukhopadhyay, Walt Johnson, Kathryn M. Taylor, K. R. Iverson, Abebe Bekele, Isabelle Citron, Kristin A. Sonderman, Katherine Albutt, Desmond T. Jumbam, Robert Riviello, John G. Meara
Publikováno v:
BJS Open, Vol 3, Iss 5, Pp 722-732 (2019)
BJS Open
BJS Open
Emergency and essential surgical, obstetric and anaesthesia (SOA) care are now recognized components of universal health coverage, necessary for a functional health system. To improve surgical care at a national level, strategic planning addressing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e87b550e27541c2da6083c160a0d183
https://doaj.org/article/f31e03f848da4682b14588d81eff005f
https://doaj.org/article/f31e03f848da4682b14588d81eff005f
Autor:
Rodrigo Vaz Ferreira, John G. Meara, Isabelle Citron, Nivaldo Alonso, David Ljungman, Julia Amundson, Saurabh Saluja, Michael L. Steer, Vitor Moutinho
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Background Worldwide efforts to improve access to surgical care must be accompanied by improvements in the quality of surgical care; however, these efforts are contingent on the ability to measure quality. This report describes a novel, evidence-base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98febefc6a832530ba0525e186dccc81
https://doi.org/10.1016/j.surg.2018.05.016
https://doi.org/10.1016/j.surg.2018.05.016
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 304:G516-G526
Pancreatic acinar cells express proteinase-activated receptor-2 (PAR2) that is activated by trypsin-like serine proteases and has been shown to exert model-specific effects on the severity of experimental pancreatitis, i.e., PAR2−/− mice are prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c51a03913296e0043372ebc5d59cb2f
https://doi.org/10.1152/ajpgi.00296.2012
https://doi.org/10.1152/ajpgi.00296.2012
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 292:G1738-G1746
We have hypothesized that the colocalization of digestive zymogens with lysosomal hydrolases, which occurs during the early stages of every experimental pancreatitis model, facilitates activation of those zymogens by lysosomal hydrolases such as cath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f77baefaea3c9fff53222f5319e14ef
https://doi.org/10.1152/ajpgi.00543.2006
https://doi.org/10.1152/ajpgi.00543.2006
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 289:G686-G695
Pancreatic acini secrete digestive enzymes in response to a variety of secretagogues including CCK and agonists acting via proteinase-activated receptor-2 (PAR2). We employed the CCK analog caerulein and the PAR2-activating peptide SLIGRL-NH2to compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e821aaf548d9be9ed4a3b91dd6b231c6
https://doi.org/10.1152/ajpgi.00342.2004
https://doi.org/10.1152/ajpgi.00342.2004
Autor:
Michael L. Steer, Arun Gopal, George Perides, Patricia Andrade-Gordon, Brooke Ligon, Xiaohong Tao, Anupriya Sharma
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 288:G388-G395
Protease-activated receptor-2 (PAR-2) is a widely expressed tethered ligand receptor that can be activated by trypsin and other trypsin-like serine proteases. In the exocrine pancreas, PAR-2 activation modulates acinar cell secretion of digestive enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fe6e886000d0594daf625811cb6d01
https://doi.org/10.1152/ajpgi.00341.2004
https://doi.org/10.1152/ajpgi.00341.2004
Autor:
George Perides, Paul M. Hassoun, Michael L. Steer, Amy Simon, Satoe Takahashi, Brent H. Cochran, Liliana M. Rozo, Jhung W. Jhung, Charles Kuhn, Barry L. Fanburg, Mariano Severgnini, Robert J. Homer
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 286:L1282-L1292
Acute lung injury (ALI) is a devastating clinical problem with a mortality as high as 60%. It is now appreciated that ALI represents a cytokine excess state that involves the microvasculature of multiple organs. The signal transducers and activators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ac1122b4aa2053bf4e43fa38436fd6
https://doi.org/10.1152/ajplung.00349.2003
https://doi.org/10.1152/ajplung.00349.2003
Autor:
Michael L. Steer, Vijay P. Singh, Lakshmi Bhagat, Albert M. Song, Gijs G.D. Van Acker, Ashok K. Saluja
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 283:G1166-G1174
Cyclooxygenase-2 (COX-2), a widely distributed enzyme, plays an important role in inflammation. We have studied the role of COX-2 in acute pancreatitis and pancreatitis-associated lung injury using both the pharmacological inhibition of COX-2 and gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3c501f57d57f56bbd35729bccd44ef
https://doi.org/10.1152/ajpgi.00370.2001
https://doi.org/10.1152/ajpgi.00370.2001
Autor:
Lakshmi Bhagat, Ashok K. Saluja, Gijs J.D. Van Acker, Vijay P. Singh, Albert M. Song, Michael L. Steer
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 283:G794-G800
Intrapancreatic activation of trypsinogen is believed to play a critical role in the initiation of acute pancreatitis, but mechanisms responsible for intrapancreatic trypsinogen activation during pancreatitis have not been clearly defined. In previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0246b43261781118873a75bb67274a26
https://doi.org/10.1152/ajpgi.00363.2001
https://doi.org/10.1152/ajpgi.00363.2001