Zobrazeno 1 - 10 of 45 pro vyhledávání: '"Michael L Lucas"'
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Akademický článek
Distal organ inflammation and injury after resuscitative endovascular balloon occlusion of the aorta in a porcine model of severe hemorrhagic shock.
Autor: Yansong Li, Michael A Dubick, Zhangsheng Yang, Johnny L Barr, Brandon J Gremmer, Michael L Lucas, Corina Necsoiu, Bryan S Jordan, Andriy I Batchinsky, Leopoldo C Cancio
Publikováno v: PLoS ONE, Vol 15, Iss 11, p e0242450 (2020)
Background and objectiveResuscitative Endovascular Balloon Occlusion of Aorta (REBOA) has emerged as a potential life-saving maneuver for the management of non-compressible torso hemorrhage in trauma patients. Complete REBOA (cREBOA) is inherently as
Externí odkaz: https://doaj.org/article/0cabfaabae034a889c5cf75ca1b02e4b
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2
Immunopathological Alterations after Blast Injury and Hemorrhage in a Swine Model of Prolonged Damage Control Resuscitation
Autor: Milomir O. Simovic, Zhangsheng Yang, Bryan S. Jordan, Tamara L. Fraker, Tomas S. Cancio, Michael L. Lucas, Leopoldo C. Cancio, Yansong Li
Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7494
Trauma-related hemorrhagic shock (HS) remains a leading cause of death among military and civilian trauma patients. We have previously shown that administration of complement and HMGB1 inhibitors attenuate morbidity and mortality 24 h after injury in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8b6a2294b7f0978206b8d63c821ea6
https://doi.org/10.3390/ijms24087494
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4
Comparison of the Effects of E. coli STa with E. coli LT, Clostridium difficile Toxin A and Osmotic Burdens on Small Intestinal Fluid Transport: Additional Proof that STa is Not a Secretory Enterotoxin
Autor: C. J. R. Turkington, S. Frame, S. M. Reza, A. Sheidaee, A. H. Currie, S. Fee, Michael L. Lucas, E. McNaughton, G. Li, S. Wheeler
Publikováno v: Journal of Advances in Medicine and Medical Research. 28:1-11
Using a recirculation procedure to perfuse anaesthetised rat jejunum, E. coli STa enterotoxin can be shown to inhibit net fluid absorption profoundly, while not causing net fluid secretion, provided fluid measurement is by mass or volume. This observ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b14af93994a9e5afa2ba5b2a527764c4
https://doi.org/10.9734/jammr/2018/44118
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5
Reduction in jejunal fluid absorption in vivo through distension and cholinergic stimulation not attributable to enterocyte secretion
Autor: Michael L. Lucas, S. McColl, P. Tainsh, H. Kenward, E. McNaughton, C. J. R. Turkington, P. Watson, V. Graham, S. Sabir
Jejunal fluid absorption in vivo was reduced by distension and by hydrostatic pressure and further declined on adding E. coli STa enterotoxin but no net fluid secretion was detected. Luminal atropine reduced pressure mediated reductions in fluid abso
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf29f1207b1bffcc3d40ebefd74a388
https://eprints.gla.ac.uk/168343/1/168343.pdf
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6
The arteriolar vasodilatation model of vibrio cholerae induced diarrhoeal disease
Autor: Michael L. Lucas
Secretory diarrhoeal disease caused by enterotoxins produced by pathogenic bacteria is characterised by severe fluid loss into the intestine. A prevalent explanation for such high rates of loss, such as occur in episodes of cholera, is that intestina
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96361c06fb58f1ed77c961cf168f1d9
https://eprints.gla.ac.uk/168344/1/168344.pdf
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7
Lack of applicability of the Enterocyte Chloride ion secretion paradigm to the Pathology of Cystic Fibrosis
Autor: Michael L. Lucas
This review examines of the concept of a defective chloride channel in epithelial cells being a major cause of cystic fi brotic pathophysiology. The central concept of the defective chloride ion channel paradigm is that faulty CFTR protein or failed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7bc87beb7a8c0ff3cea8adc4b69318
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9
Diarrhoeal disease through enterocyte secretion: a doctrine untroubled by proof
Autor: Michael L. Lucas
Publikováno v: Experimental Physiology. 95:479-484
For almost 40 years, one of the principal causes of diarrhoeal disease has been thought to be fluid secretion emanating from the epithelial cells of the small and large intestine. Given the extremely large fluid losses seen in cholera, where secretio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f6ccda03bc97c987d6ea1f46ac1e7c3
https://doi.org/10.1113/expphysiol.2009.049437
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