Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Michael L Cleary"'
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143216 (2015)
Chromosomal translocations are driver mutations of human cancers, particularly leukemias. They define disease subtypes and are used as prognostic markers, for minimal residual disease monitoring and therapeutic targets. Due to their low incidence, se
Externí odkaz:
https://doaj.org/article/31d01fc8411b4f9c8e866ffa0ac5faab
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136644 (2015)
One of the challenging questions in cancer biology is how a normal cell transforms into a cancer cell. There is strong evidence that specific chromosomal translocations are a key element in this transformation process. Our studies focus on understand
Externí odkaz:
https://doaj.org/article/b2519cedb1244fa3b10df9f64b57ce79
Autor:
Akihiko Yokoyama, Francesca Ficara, Mark J Murphy, Christian Meisel, Chikako Hatanaka, Issay Kitabayashi, Michael L Cleary
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73649 (2013)
The mixed lineage leukemia (MLL) protein is an epigenetic transcriptional regulator that controls proliferative expansion of immature hematopoietic progenitors, whose aberrant activation triggers leukemogenesis. A mature MLL protein is produced by fo
Externí odkaz:
https://doaj.org/article/2ee1c1908c504520b64f99b98bc9750f
Autor:
Johan Jeong, Astraea Jager, Pablo Domizi, Mara Pavel-Dinu, Linda Gojenola, Masayuki Iwasaki, Michael C. Wei, Feng Pan, James L. Zehnder, Matthew H. Porteus, Kara L. Davis, Michael L. Cleary
Publikováno v:
Blood Advances, Vol 3, Iss 19, Pp 2825-2835 (2019)
Abstract: Chromosomal rearrangements involving the mixed lineage leukemia (MLL) gene, also known as KMT2A, are often observed in human leukemias and are generally associated with a poor prognosis. To model these leukemias, we applied clustered regula
Externí odkaz:
https://doaj.org/article/0bff7eac6dd34ab39fa5dce1d7fa2b86
Autor:
Corina Schneidawind, Johan Jeong, Dominik Schneidawind, In-Suk Kim, Jesús Duque-Afonso, Stephen Hon Kit Wong, Masayuki Iwasaki, Erin H. Breese, James L. Zehnder, Matthew Porteus, Michael L. Cleary
Publikováno v:
Blood Advances, Vol 2, Iss 8, Pp 832-845 (2018)
Abstract: Genome editing provides a potential approach to model de novo leukemogenesis in primary human hematopoietic stem and progenitor cells (HSPCs) through induction of chromosomal translocations by targeted DNA double-strand breaks. However, ver
Externí odkaz:
https://doaj.org/article/fd68330af4e74c4ca8fe1fad62b29ab2
Autor:
Patricia K. Grüninger, Franziska Uhl, Heike Herzog, Gaia Gentile, Marta Andrade-Martinez, Tobias Schmidt, Kyuho Han, David W. Morgens, Michael C. Bassik, Michael L. Cleary, Oliver Gorka, Robert Zeiser, Olaf Groß, Jesús Duque-Afonso
Publikováno v:
Cancer Gene Therapy. 29:1751-1760
B-cell precursor acute lymphoblastic leukemias (B-ALL) are characterized by the activation of signaling pathways, which are involved in survival and proliferation of leukemia cells. Using an unbiased shRNA library screen enriched for targeting signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87db4ea10920346efede75fc8eef76e0
https://doi.org/10.1038/s41417-022-00491-0
https://doi.org/10.1038/s41417-022-00491-0
Autor:
Laura Crisafulli, Sharon Muggeo, Paolo Uva, Yulei Wang, Masayuki Iwasaki, Silvia Locatelli, Achille Anselmo, Federico S. Colombo, Carmelo Carlo-Stella, Michael L. Cleary, Anna Villa, Bernhard Gentner, Francesca Ficara
Publikováno v:
Haematologica, Vol 104, Iss 9 (2019)
The balance between self-renewal and differentiation is crucial to ensure the homeostasis of the hematopoietic system, and is a hallmark of hematopoietic stem cells. However, the underlying molecular pathways, including the role of micro-RNA, are not
Externí odkaz:
https://doaj.org/article/c4a1845919864bcd9ff2d2e828f0e774
Autor:
Michael L. Cleary, Tatiana G. Kutateladze, Ravindra Majeti, Or Gozani, Gloria Mas Martin, Fangfang Zhu, Jesús Duque-Afonso, Loren Hansen, Corina Buechele, Dominik Schneidawind, Masayuki Onishi, Larissa Ikenouye, Jinfeng Shen, Brianna J. Klein, Min Huang, Stephen H.K. Wong, Qin Li, Li Zhu
Supplementary Figure 1 shows NMR and biochemical data in support of LEDGF nucleosome binding specificity. Supplementary Figure 2 shows chromatin IP data indicating requirement for LEDGF in MLL target gene localization. Supplementary Figure 3 shows gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f38444dafa014e8f741b7cd70c98a1b
https://doi.org/10.1158/2159-8290.22531023.v1
https://doi.org/10.1158/2159-8290.22531023.v1
Data from E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia
Autor:
Michael L. Cleary, Michael C. Bassik, Stephen Hon-Kit Wong, Corina Schneidawind, Jason H. Kurzer, Jue Feng, Michael C. Wei, Kyuho Han, Chiou-Hong Lin, Jesús Duque-Afonso
There is limited understanding of how signaling pathways are altered by oncogenic fusion transcription factors that drive leukemogenesis. To address this, we interrogated activated signaling pathways in a comparative analysis of mouse and human leuke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aa2306bbeb855d310e6f2c8620a9efa
https://doi.org/10.1158/0008-5472.c.6508719.v1
https://doi.org/10.1158/0008-5472.c.6508719.v1
Autor:
Michael L. Cleary, Michael C. Bassik, Stephen Hon-Kit Wong, Corina Schneidawind, Jason H. Kurzer, Jue Feng, Michael C. Wei, Kyuho Han, Chiou-Hong Lin, Jesús Duque-Afonso
Supplementary data provide further supportive evidence that E2A-PBX1 binds the regulatory regions of its target genes (Supplementary Figure 1), which are expressed in primary ALLs depending on karyotype (Supplementary Figure 2), and have oncogenic ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272fbee84e4571a1d88402704cfd4ff4
https://doi.org/10.1158/0008-5472.22413468.v1
https://doi.org/10.1158/0008-5472.22413468.v1