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pro vyhledávání: '"Michael L, Homiski"'
Autor:
Travis T, Wager, Betty A, Pettersen, Anne W, Schmidt, Douglas K, Spracklin, Scot, Mente, Todd W, Butler, Harry, Howard, Daniel J, Lettiere, David M, Rubitski, Diane F, Wong, Frank M, Nedza, Frederick R, Nelson, Hans, Rollema, Jeffrey W, Raggon, Jiri, Aubrecht, Jody K, Freeman, John M, Marcek, Julie, Cianfrogna, Karen W, Cook, Larry C, James, Linda A, Chatman, Philip A, Iredale, Michael J, Banker, Michael L, Homiski, Jennifer B, Munzner, Rama Y, Chandrasekaran
Publikováno v:
Journal of medicinal chemistry. 54(21)
The discovery of two histamine H(3) antagonist clinical candidates is disclosed. The pathway to identification of the two clinical candidates, 6 (PF-03654746) and 7 (PF-03654764) required five hypothesis driven design cycles. The key to success in id