Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Michael Kulik"'
Autor:
Jelena Ochs, Mariana P. Hanga, Georgina Shaw, Niamh Duffy, Michael Kulik, Nokilaj Tissin, Daniel Reibert, Ferdinand Biermann, Panagiota Moutsatsou, Shibani Ratnayake, Alvin Nienow, Niels Koenig, Robert Schmitt, Qasim Rafiq, Christopher J. Hewitt, Frank Barry, J. Mary Murphy
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 3, Pp n/a-n/a (2022)
Abstract Advanced therapeutic medicinal products (ATMPs) have emerged as novel therapies for untreatable diseases, generating the need for large volumes of high‐quality, clinically‐compliant GMP cells to replace costly, high‐risk and limited sc
Externí odkaz:
https://doaj.org/article/8d664c132f564d2da30264fa84d60be3
Autor:
Andreas Elanzew, Bastian Nießing, Daniel Langendoerfer, Oliver Rippel, Tobias Piotrowski, Friedrich Schenk, Michael Kulik, Michael Peitz, Yannik Breitkreuz, Sven Jung, Paul Wanek, Laura Stappert, Robert H. Schmitt, Simone Haupt, Martin Zenke, Niels König, Oliver Brüstle
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
While human induced pluripotent stem cells (hiPSCs) provide novel prospects for disease-modeling, the high phenotypic variability seen across different lines demands usage of large hiPSC cohorts to decipher the impact of individual genetic variants.
Externí odkaz:
https://doaj.org/article/f100e2b18d264ab78a0f3b16e94a76a0
Autor:
Hyejung Park, Christopher A. Haynes, Alison V. Nairn, Michael Kulik, Stephen Dalton, Kelley Moremen, Alfred H. Merrill, Jr.
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 3, Pp 480-489 (2010)
Ceramides (Cers) are important in embryogenesis, but no comprehensive analysis of gene expression for Cer metabolism nor the Cer amounts and subspecies has been conducted with an often used model: mouse embryonic stem cells (mESCs) versus embroid bod
Externí odkaz:
https://doaj.org/article/b25da03f547d4e6e816795f313239520
Autor:
Tyrone Ryba, Ichiro Hiratani, Takayo Sasaki, Dana Battaglia, Michael Kulik, Jinfeng Zhang, Stephen Dalton, David M Gilbert
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 10, p e1002225 (2011)
Many types of epigenetic profiling have been used to classify stem cells, stages of cellular differentiation, and cancer subtypes. Existing methods focus on local chromatin features such as DNA methylation and histone modifications that require exten
Externí odkaz:
https://doaj.org/article/8c6609fd5c9146c893690faa6132d5a5
Autor:
null Jelena Ochs, null Mariana P. Hanga, null Georgina Shaw, null Niamh Duffy, null Michael Kulik, null Nokilaj Tissin, null Daniel Reibert, null Ferdinand Biermann, null Panagiota Moutsatsou, null Shibani Ratnayake, null Alvin Nienow, null Niels Koenig, null Robert Schmitt, null Qasim Rafiq, null Christopher J. Hewitt, null Frank Barry, null J. Mary Murphy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee07ab682f149b4734fc48f1d20e1b49
https://doi.org/10.1002/btm2.10387/v3/response1
https://doi.org/10.1002/btm2.10387/v3/response1
Autor:
Akshay Sanghi, Stephen Dalton, Maya Kasowski, Michael Kulik, Fabian Grubert, Damek V. Spacek, Mariana Ruiz-Velasco, Qing Liu, Anshul Kundaje, Marlene Rabinovitch, Benjamin Geller, Anil Narasimha, Peyton Greenside, Judith B. Zaugg, Nasa Sinnott-Armstrong, Michael Snyder, Silin Sa, Rohith Srivas
Publikováno v:
Nature
Physical interactions between distal regulatory elements have a key role in regulating gene expression, but the extent to which these interactions vary between cell types and contribute to cell-type-specific gene expression remains unclear. Here, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7464e87b91325736eb92d4cd8a268a0f
https://doi.org/10.1038/s41586-020-2151-x
https://doi.org/10.1038/s41586-020-2151-x
Autor:
Michael Kulik, Heidi Ulrichs, Nadja Zeltner, Kazuhiro Aoki, Kevin A. Strauss, Mayumi Ishihara, Michelle Dookwah, Stephen Dalton, Richard Steet, Shannon K. Wagner, Michael Tiemeyer, Seok-Ho Yu
GM3 Synthase Deficiency (GM3SD) is a neurodevelopmental disorder resulting from pathogenic variants in the ST3GAL5 gene, which encodes GM3 synthase, a glycosphingolipid (GSL)-specific sialyltransferase. This enzyme adds a single α3-linked sialic aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81e174d3d1b13d73a47dc2e5cfd71229
https://doi.org/10.1101/2021.07.29.454399
https://doi.org/10.1101/2021.07.29.454399
Autor:
Michael Kulik, Deepti M. Warad, Nathalie Seta, Mathieu Fiore, Anne Dell, Sandrine Vuillaumier-Barrot, Zhi-Jie Xia, Tadahiro Kumagai, Hudson H. Freeze, François Fenaille, Katherine Mcgoogan, Kimiyo Raymond, Mindy Porterfield, Thierry Dupré, Marie-Christine Vergnes-Boiteux, Deborah A. Nickerson, Michael Tiemeyer, Sophie Cholet, Michael J. Bamshad, Caroline Michot, Arnaud Bruneel, Tiffany Pascreau, Heather Flanagan-Steet, Shannon M. Wagner, Stuart M. Haslam, Bobby G. Ng, Delphine Borgel, Paulina Sosicka, Stephen Dalton, Richard Steet, Yohann Huguenin, Annie Harroche
Publikováno v:
American Journal of Human Genetics
American Journal of Human Genetics, 2021, 108 (6), pp.1040-1052. ⟨10.1016/j.ajhg.2021.04.013⟩
Am J Hum Genet
American Journal of Human Genetics, Elsevier (Cell Press), 2021, 108 (6), pp.1040-1052. ⟨10.1016/j.ajhg.2021.04.013⟩
American Journal of Human Genetics, 2021, 108 (6), pp.1040-1052. ⟨10.1016/j.ajhg.2021.04.013⟩
Am J Hum Genet
American Journal of Human Genetics, Elsevier (Cell Press), 2021, 108 (6), pp.1040-1052. ⟨10.1016/j.ajhg.2021.04.013⟩
International audience; SLC37A4 encodes an endoplasmic reticulum (ER)-localized multitransmembrane protein required for transporting glucose-6-phosphate (Glc-6P) into the ER. Once transported into the ER, Glc-6P is subsequently hydrolyzed by tissue-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a6e63388ac47d2efef992f6e46252b
https://hal.inrae.fr/hal-03321294
https://hal.inrae.fr/hal-03321294
Autor:
Daniel A. Bartlett, Korey A. Wilson, Xiaowen Lyu, Rachel Patton McCord, Peiyao A. Zhao, David M. Gilbert, Zhaohui S. Qin, Allan J. Robins, Vishnu Dileep, Ben Li, Thomas C. Schulz, Victor G. Corces, Axel Poulet, Stephen Dalton, Claire Marchal, Michael Kulik, Juan Carlos Rivera-Mulia, Job Dekker
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 13, Iss 1, Pp 193-206 (2019)
Stem Cell Reports, Vol 13, Iss 1, Pp 193-206 (2019)
Summary The temporal order of DNA replication is regulated during development and is highly correlated with gene expression, histone modifications and 3D genome architecture. We tracked changes in replication timing, gene expression, and chromatin co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e2e295c8e62050b2ff2afe8ee1a0b2
https://doi.org/10.1016/j.stemcr.2019.05.021
https://doi.org/10.1016/j.stemcr.2019.05.021
Autor:
Sarah Brennenstuhl, Kara McWatters, Martine Puts, Raymond Jang, Shabbir M.H. Alibhai, Michael Kulik, Mary Ellen MacDonald, Johanne Monette, Eitan Amir, Katherine Lee, Anthony M. Joshua, D. Wan-Chow-Wah, Schroder Sattar, Monika K. Krzyzanowska
Publikováno v:
Supportive Care in Cancer. 26:109-117
Geriatric assessment and management (GAM) can identify current health issues and recommend interventions to optimize well-being of older adults, but no randomized trial has yet been completed in oncology. Therefore, a randomized phase 2 trial was con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c933468bd7db31b961a1fd1361d940
https://doi.org/10.1007/s00520-017-3820-7
https://doi.org/10.1007/s00520-017-3820-7