The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids

Autor: Emily Amor Stander, Beata Lehka, Inês Carqueijeiro, Clément Cuello, Frederik G. Hansson, Hans J. Jansen, Thomas Dugé De Bernonville, Caroline Birer Williams, Valentin Vergès, Enzo Lezin, Marcus Daniel Brandbjerg Bohn Lorensen, Thu-Thuy Dang, Audrey Oudin, Arnaud Lanoue, Mickael Durand, Nathalie Giglioli-Guivarc’h, Christian Janfelt, Nicolas Papon, Ron P. Dirks, Sarah Ellen O’connor, Michael Krogh Jensen, Sébastien Besseau, Vincent Courdavault

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-19 (2023)

Abstract Monoterpene indole alkaloids (MIAs) are a structurally diverse family of specialized metabolites mainly produced in Gentianales to cope with environmental challenges. Due to their pharmacological properties, the biosynthetic modalities of se

Externí odkaz: https://doaj.org/article/60239ee0c7994813904a74c32f5c4947

Burden Imposed by Heterologous Protein Production in Two Major Industrial Yeast Cell Factories: Identifying Sources and Mitigation Strategies

Autor: Louise La Barbera Kastberg, Ryan Ard, Michael Krogh Jensen, Christopher T. Workman

Publikováno v: Frontiers in Fungal Biology, Vol 3 (2022)

Production of heterologous proteins, especially biopharmaceuticals and industrial enzymes, in living cell factories consumes cellular resources. Such resources are reallocated from normal cellular processes toward production of the heterologous prote

Externí odkaz: https://doaj.org/article/e112c955619a4bc78e40a5e17ff51fd9

Genome Assembly of the Medicinal Plant Voacanga thouarsii

Autor: Clément, Cuello, Emily Amor, Stander, Hans J, Jansen, Thomas, Dugé de Bernonville, Arnaud, Lanoue, Nathalie, Giglioli-Guivarc'h, Nicolas, Papon, Ron P, Dirks, Michael Krogh, Jensen, Sarah Ellen, O'Connor, Sébastien, Besseau, Vincent, Courdavault

Publikováno v: Genome biology and evolution. 14(11)

The Apocynaceae tree Voacanga thouarsii, native to southern Africa and Madagascar, produces monoterpene indole alkaloids (MIA), which are specialized metabolites with a wide range of bioactive properties. Voacanga species mainly accumulates tabersoni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd420c90d9d257e213f31e659f88e6e1
https://pubmed.ncbi.nlm.nih.gov/36300641

The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis

Autor: Emily Amor, Stander, Clément, Cuello, Caroline, Birer-Williams, Natalja, Kulagina, Hans J, Jansen, Ines, Carqueijeiro, Louis-Valentin, Méteignier, Valentin, Vergès, Audrey, Oudin, Nicolas, Papon, Ron P, Dirks, Michael Krogh, Jensen, Sarah Ellen, O'Connor, Thomas, Dugé de Bernonville, Sébastien, Besseau, Vincent, Courdavault

Publikováno v: G3 (Bethesda, Md.). 12(12)

Vinca minor, also known as the lesser periwinkle, is a well-known species from the Apocynaceae, native to central and southern Europe. This plant synthesizes monoterpene indole alkaloids, which are a class of specialized metabolites displaying a wide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b88d038607b136a662ef7536366d75e8
https://pubmed.ncbi.nlm.nih.gov/36200869

Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism

Autor: Michael Krogh Jensen, Jens Nielsen, Jie Zhang, Eduardo Abeliuk, Zak Costello, Andrés Ramirez, Andrés Pérez-Manríquez, Benjamin Sanchez, Søren D. Petersen, Jay D. Keasling, Hector Garcia Martin, Michael J. Fero, Tijana Radivojevic, Yu Chen

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Zhang, J, Petersen, S D, Radivojevic, T, Ramirez, A, Pérez-Manríquez, A, Abeliuk, E, Sánchez, B J, Costello, Z, Chen, Y, Fero, M J, Martin, H G, Nielsen, J, Keasling, J D & Jensen, M K 2020, ' Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism ', Nature Communications, vol. 11, no. 1, 4880 . https://doi.org/10.1038/s41467-020-17910-1

Through advanced mechanistic modeling and the generation of large high-quality datasets, machine learning is becoming an integral part of understanding and engineering living systems. Here we show that mechanistic and machine learning models can be c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e52e82bd0714a12e1be42785be8cff
http://link.springer.com/article/10.1038/s41467-020-17910-1