Zobrazeno 1 - 10 of 60 pro vyhledávání: '"Michael Krams"'
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Akademický článek
Normative data from linear and nonlinear quantile regression in CANTAB: Cognition in mid‐to‐late life in an epidemiological sample
Autor: Rosemary A. Abbott, Caroline Skirrow, Martha Jokisch, Maarten Timmers, Johannes Streffer, Luc vanNueten, Michael Krams, Angela Winkler, Noreen Pundt, Pradeep J. Nathan, Philippa Rock, Francesca K. Cormack, Christian Weimar
Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 36-44 (2019)
Abstract Introduction Normative cognitive data can help to distinguish pathological decline from normal aging. This study presents normative data from the Cambridge Neuropsychological Test Automated Battery, using linear regression and nonlinear quan
Externí odkaz: https://doaj.org/article/ce4cd7f92aa64b51b50a40ec03bcd060
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2
Akademický článek
Accurate prediction of clinical stroke scales and improved biomarkers of motor impairment from robotic measurements.
Autor: Dimitris K Agrafiotis, Eric Yang, Gary S Littman, Geert Byttebier, Laura Dipietro, Allitia DiBernardo, Juan C Chavez, Avrielle Rykman, Kate McArthur, Karim Hajjar, Kennedy R Lees, Bruce T Volpe, Michael Krams, Hermano I Krebs
Publikováno v: PLoS ONE, Vol 16, Iss 1, p e0245874 (2021)
ObjectiveOne of the greatest challenges in clinical trial design is dealing with the subjectivity and variability introduced by human raters when measuring clinical end-points. We hypothesized that robotic measures that capture the kinematics of huma
Externí odkaz: https://doaj.org/article/cbae07005d904d3fb81653c7a729a3dd
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4
Abstract CT114: Data from first-in-human study of EXS21546, an A2A receptor antagonist, now progressing into phase 1 in RCC/NSCLC
Autor: Nieves Diaz, Holly Garratt, Aleksandra Zemla-Brown, Maria Dominguez, Eric Helmer, Isabella Alt, Robert Sehlke, Norbert Hieger, Thomas Winkler-Penz, Christophe Boudesco, Gregory Vladimer, Tom Wilde, Philip Evans, Antoine Italiano, Michael Krams
Publikováno v: Cancer Research. 83:CT114-CT114
Background: EXS21546 (discovered in collaboration with Evotec) is a clinical stage A2AR selective antagonist with high potential in cancer immunotherapy as a combination agent. A completed healthy volunteer (HV) first-in-human (FIH) study is now bein
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c6343da98243e741a479fc314908521
https://doi.org/10.1158/1538-7445.am2023-ct114
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5
Accelerating the Availability of Medications to Pediatric Patients by Optimizing the Use of Extrapolation of Efficacy
Autor: Allison, Dunn, Dawoon, Jung, Lisa L, Bollinger, Michael, Krams, Brian P, Smith, Jogarao V S, Gobburu
Publikováno v: Therapeutic innovationregulatory science. 56(6)
Improving pediatric therapeutic development is a mission of universal importance among health authorities, pharmaceutical companies, academic institutions, and healthcare professionals. Following the passage of legislation in the United States and Eu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::195da111e114cf935096bb2938035069
https://pubmed.ncbi.nlm.nih.gov/35471560
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6
Accurate prediction of clinical stroke scales and improved biomarkers of motor impairment from robotic measurements
Autor: Karim Hajjar, Eric Yang, Allitia DiBernardo, Juan C. Chavez, Avrielle Rykman, Gary S. Littman, Michael Krams, Kate McArthur, Bruce T. Volpe, Dimitris K. Agrafiotis, Kennedy R. Lees, Laura Dipietro, Geert Byttebier, Hermano Igo Krebs
Publikováno v: PLoS ONE, Vol 16, Iss 1, p e0245874 (2021)
PLoS ONE
Objective One of the greatest challenges in clinical trial design is dealing with the subjectivity and variability introduced by human raters when measuring clinical end-points. We hypothesized that robotic measures that capture the kinematics of hum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccee51a21951f845624be1c2d4570d9
https://doaj.org/article/cbae07005d904d3fb81653c7a729a3dd
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7
Normative data from linear and nonlinear quantile regression in CANTAB: Cognition in mid-to-late life in an epidemiological sample
Autor: Francesca Cormack, Noreen Pundt, Maarten Timmers, Johannes Streffer, Luc Van Nueten, Martha Jokisch, Caroline Skirrow, Christian Weimar, Philippa Rock, Rosemary A. Abbott, Pradeep J. Nathan, Michael Krams, Angela Winkler
Publikováno v: Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 36-44 (2019)
Introduction Normative cognitive data can help to distinguish pathological decline from normal aging. This study presents normative data from the Cambridge Neuropsychological Test Automated Battery, using linear regression and nonlinear quantile regr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79186c005198d25fee3dee0b5938c72
http://europepmc.org/articles/PMC6305838
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8
New Approaches in Translational Medicine for Phase I Clinical Trials of CNS Drugs
Autor: Matthew Macaluso, Michael Krams, Wayne C. Drevets, Jonathan Savitz, Sheldon H. Preskorn
Phase I clinical trials have traditionally been focused on populations of normal healthy volunteers with the goal of determining the safety, tolerability, and pharmacokinetic profile of new investigational agents. As CNS drug development shifts its f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2999efc55d32a87df0428da9d1019f93
https://doi.org/10.1016/b978-0-12-803161-2.00006-0
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9
Continuous event monitoring via a Bayesian predictive approach
Autor: Daniel Wang, Michael Krams, Jianing Di, H. Robert Brashear, Vladimir Dragalin
Publikováno v: Pharmaceutical Statistics. 15:109-122
In clinical trials, continuous monitoring of event incidence rate plays a critical role in making timely decisions affecting trial outcome. For example, continuous monitoring of adverse events protects the safety of trial participants, while continuo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d58b9008eb6b8aeef296c2ce816c90
https://doi.org/10.1002/pst.1727
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10
Building a roadmap for developing combination therapies for Alzheimer’s disease
Autor: Stephen Salloway, Maria C. Carrillo, John Q. Trojanowski, Robert Temple, Val Gribkoff, Lisa J. Bain, Enchi Liu, David M. Dilts, C. Bountra, Diane Stephenson, Russell Katz, Cynthia Bens, Tony Ware, Steven G. Potkin, Heather M. Snyder, F. Owen Fields, Johan Luthman, Michael Krams, Yaning Wang, Daniel Perry, Reisa A. Sperling, John C. McKew, Debra Hanna, Donald A. Berry
Publikováno v: Expert Review of Neurotherapeutics. 15:327-333
Combination therapy has proven to be an effective strategy for treating many of the world's most intractable diseases. A growing number of investigators in academia, industry, regulatory agencies, foundations and advocacy organizations are interested
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ded341959d66bc0d9af0f38283fb361
https://doi.org/10.1586/14737175.2015.996551
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