Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michael Kotliar"'
Autor:
Sarah J. Potter, Li Zhang, Michael Kotliar, Yuehong Wu, Caitlin Schafer, Kurtis Stefan, Leandros Boukas, Dima Qu’d, Olaf Bodamer, Brittany N. Simpson, Artem Barski, Andrew W. Lindsley, Hans T. Bjornsson
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Individuals with Kabuki syndrome present with immunodeficiency; however, how pathogenic variants in the gene encoding the histone-modifying enzyme lysine methyltransferase 2D (KMT2D) lead to immune alterations remain poorly understood. Following up o
Externí odkaz:
https://doaj.org/article/cf9678b7fb124e57af5f1be2328c292d
Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis
Autor:
Steven P. Proper, Alexander T. Dwyer, Andrews Appiagyei, Jennifer M. Felton, Netali Ben-Baruch Morgenstern, Justin M. Marlman, Michael Kotliar, Artem Barski, Ty D. Troutman, Marc E. Rothenberg, Tesfaye B. Mersha, Nurit P. Azouz
Publikováno v:
Frontiers in Allergy, Vol 5 (2024)
IntroductionAtopic dermatitis (AD) is an allergic skin disease mediated by skin barrier impairment and IL-13-driven immune response. Activation of the aryl hydrocarbon receptor (AHR) has shown promise in early clinical trials for AD; however, the mec
Externí odkaz:
https://doaj.org/article/250f10865655442983c6157c3f1b2cd5
Autor:
Tareian A Cazares, Faiz W Rizvi, Balaji Iyer, Xiaoting Chen, Michael Kotliar, Anthony T Bejjani, Joseph A Wayman, Omer Donmez, Benjamin Wronowski, Sreeja Parameswaran, Leah C Kottyan, Artem Barski, Matthew T Weirauch, V B Surya Prasath, Emily R Miraldi
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010863 (2023)
Transcription factors read the genome, fundamentally connecting DNA sequence to gene expression across diverse cell types. Determining how, where, and when TFs bind chromatin will advance our understanding of gene regulatory networks and cellular beh
Externí odkaz:
https://doaj.org/article/47ad65dfdd1a46f0b5c46cc8a247f53a
Autor:
Mark Rochman, Ting Wen, Michael Kotliar, Phillip J. Dexheimer, Netali Ben-Baruch Morgenstern, Julie M. Caldwell, Hee-Woong Lim, Marc E. Rothenberg
Publikováno v:
JCI Insight, Vol 7, Iss 11 (2022)
Inflammation of the esophageal epithelium is a hallmark of eosinophilic esophagitis (EoE), an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells at single-cell resolution during homeostasis and EoE. During allergic
Externí odkaz:
https://doaj.org/article/c6e06d004a604d599dd0fd4e1029847b
Autor:
Aizhan Surumbayeva, Michael Kotliar, Linara Gabitova-Cornell, Andrey Kartashov, Suraj Peri, Nathan Salomonis, Artem Barski, Igor Astsaturov
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100989- (2021)
Summary: Preparation of single-cell suspension from primary tumor tissue can provide a valuable resource for functional, genetic, proteomic, and tumor microenvironment studies. Here, we describe an effective protocol for mouse pancreatic tumor dissoc
Externí odkaz:
https://doaj.org/article/589e50c6390a4226890022c165a66ffb
Autor:
Michael Brusilovsky, Mark Rochman, Tetsuo Shoda, Michael Kotliar, Julie M Caldwell, Lydia E Mack, John A Besse, Xiaoting Chen, Matthew T Weirauch, Artem Barski, Marc E Rothenberg
Publikováno v:
Gut. 72:834-845
ObjectiveThe contribution of vitamin D (VD) deficiency to the pathogenesis of allergic diseases remains elusive. We aimed to define the impact of VD on oesophageal allergic inflammation.DesignWe assessed the genomic distribution and function of VD re
Autor:
Sarah J Potter, Li Zhang, Michael Kotliar, Yuehong Wu, Caitlin Schafer, Kurtis Stefan, Leandros Boukas, Dima Qu’d, Olaf Bodamer, Brittany N Simpson, Artem Barski, Andrew W Lindsley, Hans T Bjornsson
ObjectiveThere is a clinical need to understand how dysregulated thymocyte development, caused by pathogenic variants in the gene encoding the histone-modifying enzyme, lysine methyltransferase 2D (KMT2D), contributes to immune dysfunction, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29c23032151b736380beb719e9be9406
https://doi.org/10.1101/2022.10.04.510662
https://doi.org/10.1101/2022.10.04.510662
Autor:
Marc E. Rothenberg, Artem Barski, Matthew T. Weirauch, Jennifer M Felton, Kevin Ernst, Lee Edsall, Patricia C. Fulkerson, Benjamin Wronowski, Sreeja Parameswaran, Sushmitha Vallabh, Astha Malik, Michael Kotliar
Publikováno v:
The Journal of Immunology. 207:1044-1054
Eosinophils develop in the bone marrow from hematopoietic progenitors into mature cells capable of a plethora of immunomodulatory roles via the choreographed process of eosinophilopoiesis. However, the gene regulatory elements and transcription facto
Autor:
Tareian A. Cazares, Faiz W. Rizvi, Balaji Iyer, Xiaoting Chen, Michael Kotliar, Anthony T. Bejjani, Joseph A. Wayman, Omer Donmez, Benjamin Wronowski, Sreeja Parameswaran, Leah C. Kottyan, Artem Barski, Matthew T. Weirauch, VB Surya Prasath, Emily R. Miraldi
Transcription factors read the genome, fundamentally connecting DNA sequence to gene expression across diverse cell types. Determining how, where, and when TFs bind chromatin will advance our understanding of gene regulatory networks and cellular beh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d975a5dcbc9bd26e8437541c0ebf5b
https://doi.org/10.1101/2022.01.28.478235
https://doi.org/10.1101/2022.01.28.478235
Autor:
Aizhan Surumbayeva, Riley Williams, Michael Kotliar, Maryclare Taylor, Débora B. Vendramini Costa, Charline Ogier, Diana Restifo, Kathy Q. Cai, Xueyang He, Paul Boutz, Siddharth Balachandran, Igor Astsaturov
Publikováno v:
Cancer Research. 82:B019-B019
Mortality from colon and pancreatic cancers arises from cancer metastatic dissemination to the liver. The glycemic load from carbohydrates (carbs) has been specifically linked to the risk of metastatic recurrence of stage 3 colorectal cancer, but the