Independent large scale duplications in multiple M. tuberculosis lineages overlapping the same genomic region.

Autor: Brian Weiner, James Gomez, Thomas C Victor, Robert M Warren, Alexander Sloutsky, Bonnie B Plikaytis, James E Posey, Paul D van Helden, Nicolass C Gey van Pittius, Michael Koehrsen, Peter Sisk, Christian Stolte, Jared White, Sebastien Gagneux, Bruce Birren, Deborah Hung, Megan Murray, James Galagan

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e26038 (2012)

Mycobacterium tuberculosis, the causative agent of most human tuberculosis, infects one third of the world's population and kills an estimated 1.7 million people a year. With the world-wide emergence of drug resistance, and the finding of more functi

Externí odkaz: https://doaj.org/article/9d45c4662e0341f6ad7deca18843397f

Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients

Autor: Florian Bihl, Raymond T. Chung, Arne Schneidewind, Edward D. Gomperts, Bruce W. Birren, Gerond Lake-Bakaar, David Heckerman, Chad Nusbaum, Zhimin Liu, Niall Lennon, Hugo R. Rosen, James E. Galagan, Bongshin Lee, Sharyne M. Donfield, Andrew Berical, Tony N. Marion, Arthur Y. Kim, Joerg Timm, Vicki M. Park, Michael Koehrsen, Andreas Cerny, Ulrich Spengler, Andrew H. Talal, Margaret A. Madey, Yanming Xing, Eric S. Daar, Laura L. Reyor, Thomas Kuntzen, Ira M. Jacobson, Bruce D. Walker, Jaquelyn Fleckenstein, Jonathan M. Carlson, Marianna Kleyman, Todd M. Allen, Matthew R. Henn, Chinnappa D. Kodira, Aaron M. Berlin, Brian R. Edlin, Timothy Ledlie, Cory M. McMahon, Georg M. Lauer, Sarah Young, Christopher E. Birch, Julian Schulze zur Wiesch, Andrew Roberts

Publikováno v: Hepatology. 48:1769-1778

Resistance mutations to hepatitis C virus (HCV) nonstructural protein 3 (NS3) protease inhibitors in1% of the viral quasispecies may still allow1000-fold viral load reductions upon treatment, consistent with their reported reduced replicative fitness

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6b5204dcc09269393cbdb640d9f676
https://doi.org/10.1002/hep.22549

Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium

Autor: Xiaohui Xie, Liande Li, B. Gillian Turgeon, Daren W. Brown, Christina A. Cuomo, Etienne Danchin, M. Carmen Ruiz-Roldán, Ilan Wapinski, Petra M. Houterman, Aviv Regev, Sharadha Sakthikumar, Diego Miranda-Saavedra, James E. Galagan, Lokesh Kumar, Michael Koehrsen, Divya Sain, Sean M. Sykes, Martijn Rep, Yong-Hwan Lee, Chinnappa D. Kodira, Andrew C. Diener, Li-Jun Ma, B. H. Bluhm, Won-Bo Shim, Kim E. Hammond-Kosack, H. Charlotte van der Does, Jeffrey J. Coleman, Jin-Rong Xu, David C. Schwartz, John F. Antoniw, John M. Manners, Robert H. Proctor, Sook Young Park, Sinéad B. Chapman, Seogchan Kang, Liane R. Gale, Kemal Kazan, Karen Hilburn, Pedro M. Coutinho, Olen C. Yoder, Stephen A. Goff, Robert A. E. Butchko, Gyungsoon Park, Bernard Henrissat, Katherine A. Borkovich, H. Corby Kistler, Michael Freitag, Aurélie Hua-Van, Mala Mukherjee, Scott E. Baker, Shiguo Zhou, Qiandong Zeng, Donald M. Gardiner, Manfred Grabherr, Wilfried Jonkers, Marie Josée Daboussi, Marie Dufresne, Andrew Breakspear, Charles P. Woloshuk, Antonio Di Pietro, Sarah Young, Richard M.R. Coulson, Jongsun Park

Publikováno v: Nature
Nature, Nature Publishing Group, 2010, 464 (7287), pp.367-373
Nature, 464(7287), 367-373. Nature Publishing Group
Nature, 2010, 464 (7287), pp.367-373. ⟨10.1038/nature08850⟩
Nature, Nature Publishing Group, 2010, 464 (7287), pp.367-73. ⟨10.1038/nature08850⟩

International audience; Fusarium species are among the most important phytopathogenic and toxigenic fungi. To understand the molecular underpinnings of pathogenicity in the genus Fusarium, we compared the genomes of three phenotypically diverse speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2fe83657fc753869d9f7546bd26966
https://europepmc.org/articles/PMC3048781/

Comparative genomic characterization of Francisella tularensis strains belonging to low and high virulence subspecies

Autor: Stephen L. Michell, Francis E. Nano, James E. Galagan, Mats Forsman, Jared White, Richard W. Titball, Michael Koehrsen, Scott W. Bearden, Chinnappa D. Kodira, Anders Sjöstedt, Qiandong Zeng, Reinhard Engels, Eli B. Nix, Sarah Young, Bruce W. Birren, Clint Howarth, Matthew D. Pearson, Lisa Larson, Mia D. Champion, Mark L. Borowsky, Lucia Alvarado, Paul Keim

Publikováno v: PLoS Pathogens, Vol 5, Iss 5, p e1000459 (2009)
PLoS Pathogens

Tularemia is a geographically widespread, severely debilitating, and occasionally lethal disease in humans. It is caused by infection by a gram-negative bacterium, Francisella tularensis. In order to better understand its potency as an etiological ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cede163b47442b077eda3055cf5598c
http://europepmc.org/articles/PMC2682660?pdf=render

Independent Large Scale Duplications in Multiple M. tuberculosis Lineages Overlapping the Same Genomic Region

Autor: Nicolass C. Gey van Pittius, Sebastien Gagneux, Robert M. Warren, James Gomez, Brian Weiner, Paul D. van Helden, James E. Posey, Deborah T. Hung, Bonnie B. Plikaytis, Peter Sisk, Alexander Sloutsky, Michael Koehrsen, Thomas C. Victor, Christian Stolte, Megan Murray, James E. Galagan, Jared White, Bruce W. Birren

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e26038 (2012)
PloS one
PLoS ONE

Mycobacterium tuberculosis, the causative agent of most human tuberculosis, infects one third of the world's population and kills an estimated 1.7 million people a year. With the world-wide emergence of drug resistance, and the finding of more functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52c25915a0976d4f78da9cf4c8bc6be
https://doi.org/10.1371/journal.pone.0026038