Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael Keoni Manion"'
Publikováno v:
Journal of Molecular Biology. 356:367-381
Dimeric interactions among anti- and pro-apoptotic members of the BCL-2 protein family are dynamically regulated and intimately involved in survival and death functions. We report the structure of a BCL-X(L) homodimers a 3D-domain swapped dimer (3DDS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5ff2dd03c0175e3526511886c05eae
https://doi.org/10.1016/j.jmb.2005.11.032
https://doi.org/10.1016/j.jmb.2005.11.032
Publikováno v:
Cancer Biology & Therapy. 2:104-113
The BCL-2 family proteins are attractive targets for drug design. As pivotal regulators of apoptotic cell death, the logic of manipulating BCL-2 functions for anti-tumor effects is perhaps the strongest for any of the molecular targets proposed for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::301fc92b4442fe2eb47aacaa6c83d00b
https://doi.org/10.4161/cbt.209
https://doi.org/10.4161/cbt.209
Publikováno v:
Biochemical and Biophysical Research Communications. 277:462-469
We have used the method of inverted hydropathy to develop peptides that interact with EF hands of calmodulin (CaM). Previously we have shown these peptides specifically interact with their desired target in a productive manner, in that they activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a95d8948100187557474214f9afab4
https://doi.org/10.1006/bbrc.2000.3691
https://doi.org/10.1006/bbrc.2000.3691
Publikováno v:
Biochimica et biophysica acta. 1705(1)
Cancer cells with elevated levels of BCL-2 and related survival proteins are broadly resistant to cytotoxic agents. Antisense oligodeoxynucleotides, and more recently small molecule ligands for BCL-2 and BCL-XL, are directly cytotoxic or synergistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32644b94eabb6f511b44042a37c51f48
https://pubmed.ncbi.nlm.nih.gov/15585172
https://pubmed.ncbi.nlm.nih.gov/15585172
Autor:
Kam Y.Z. Zhang, Chris D. Giedt, Jason W. O'Neill, Kristine M. Kim, Michael Keoni Manion, David M. Hockenbery
Publikováno v:
The Journal of biological chemistry. 279(3)
Cells expressing high levels of the BCL-X(L) anti-apoptotic protein are preferentially killed by the mitochondrial inhibitor antimycin A (AA). Computational modeling predicts a binding site for AA in the extended hydrophobic groove on BCL-X(L), previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0e886324927a924d3857e597f723e1
https://pubmed.ncbi.nlm.nih.gov/14534311
https://pubmed.ncbi.nlm.nih.gov/14534311
Publikováno v:
The Analyst. 129:205
Monitoring extracellular acidification rates (ECARs) is important for the study of cellular activities, since it allows for the evaluation of factors that alter metabolic function, such as stimulants, inhibitors, toxins as well as receptor and non-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aee348696a150cce4d3a9a8a4f214c4b
https://doi.org/10.1039/b315007k
https://doi.org/10.1039/b315007k
Autor:
Thea Leusink-Muis, Gert Folkerts, Frans P. Nijkamp, Matteo Villain, Robert Ten Broeke, Michael Keoni Manion, J. Edwin Blalock, Henk J. van der Linde, Fred De Clerck
Publikováno v:
Scopus-Elsevier
SPECIFIC AIMSIn the present study, we used two calcium-like peptides (CALP1 and CALP2) to test the hypothesis that calcium channels in the epithelium play a role in regulating airway responsiveness by controlling [Ca2+]i and, consequently, modulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc085f427a9df0f8bab92ed95fe1607
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035433908&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035433908&partnerID=MN8TOARS
