Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michael Kastenberger"'
Autor:
Wolfgang Mueller-Klieser, Evelyn Ullrich, E. K. Geissler, Andreas Villunger, Almut Brand, Sigrid Karrer, Kathrin Renner, André Steven, Peter J. Oefner, Stefan Walenta, Elisabeth Kohl, Annette Thiel, Christian U. Blank, Gudrun E. Koehl, Jacques Pouysségur, Sebastian Haferkamp, Maximilian Schmid, Marina Kreutz, Carina Matos, Stefan Fichtner-Feigl, Katja Dettmer, Petra Hoffmann, Ulrike Schleicher, Sebastian Klobuch, Barbara Seliger, Katrin Singer, Michael Kastenberger, Christian Bogdan, Matthias Mack, Mark Berneburg, K. Peter, Stephan Schreml, Uwe Ritter, Wolfgang Herr, Marlene Kolitzus, Andreas Mackensen, Christina Bruss, Rebecca Kesselring, Gabriele Schoenhammer
Publikováno v:
Cell Metabolism. 24:657-671
Elevated lactate dehydrogenase A (LDHA) expression is associated with poor outcome in tumor patients. Here we show that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells. In immunocompetent C57BL/6 mi
Autor:
Eva Gottfried, Michael Aigner, Katrin Singer, Andreas Mackensen, Reinhard Andreesen, Marina Kreutz, Bernhard Walter, Arndt Hartmann, Hans Schlösser, Barbara Seliger, Christine G. Hammerschmied, Michael Kastenberger, Maike Büttner
Publikováno v:
International Journal of Cancer. 128:2085-2095
Many tumor cells are characterized by a dysregulated glucose metabolism associated with increased glycolysis in the presence of oxygen ("Warburg Effect"). Here, we analyzed for the first time a possible link between glucose metabolism and immune cell
Autor:
Michael Kastenberger, Anett Doerfelt, Thomas Nickl-Jockschat, Ulrich Bogdahn, Anja-Katrin Bosserhoff, Peter Hau, Fusun Baumann, Peter J. Oefner, Petra Leukel, Christoph P. Beier, Marina Kreutz, Katja Dettmer
Publikováno v:
Neuro-Oncology. 11:368-380
Lactate dehydrogenase type A (LDH-A) is a key metabolic enzyme catalyzing pyruvate into lactate and is excessively expressed by tumor cells. Transforming growth factor-beta2 (TGF-beta2) is a key regulator of invasion in high-grade gliomas, partially
Autor:
Kathrin Renner, Eva Gottfried, Katrin Dietl, Leoni A. Kunz-Schughart, Michael Kastenberger, Reinhard Andreesen, Christoph Dorn, Claus Hellerbrand, Peter J. Oefner, Karin Eberhart, Birgit Timischl, Marina Kreutz, Katja Dettmer
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 184(3)
High concentrations of lactic acid (LA) are found under various pathophysiological conditions and are accompanied by an acidification of the environment. To study the impact of LA on TNF secretion, human LPS-stimulated monocytes were cultured with or