Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michael K.E. Schäfer"'
Autor:
Irina Staib-Lasarzik, Christina Gölz, Wieslawa Bobkiewiecz, Pawit Somnuke, Anne Sebastiani, Serge C. Thal, Michael K.E. Schäfer
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35198- (2024)
Traumatic brain injury (TBI) is characterized by complex secondary injury processes involving the p75 neurotrophin receptor (p75NTR), which has been proposed as a possible therapeutic target. However, the pathogenic role of the p75NTR co-receptor sor
Externí odkaz:
https://doaj.org/article/d20877ef28ab4b2ab1b138bea0f22959
Publikováno v:
BMC Neuroscience, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract TBI is a leading cause of death and disability in young people and older adults worldwide. There is no gold standard treatment for TBI besides surgical interventions and symptomatic relief. Post-injury infections, such as lower respiratory t
Externí odkaz:
https://doaj.org/article/29041a40f0014eff812b4e6caddb9c92
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 5, Pp 1236-1243 (2025)
The N-terminal EF-hand calcium-binding proteins 1–3 (NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-termin
Externí odkaz:
https://doaj.org/article/86cd6c606f324f18a33befe8fb30a11d
Autor:
Zhuofeng Ding, Xiaoshen Liang, Jian Wang, Zongbin Song, Qulian Guo, Michael K.E. Schäfer, Changsheng Huang
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102700- (2023)
Bone cancer pain (BCP) impairs patients’ quality of life. However, the underlying mechanisms are still unclear. This study investigated the role of spinal interneuron death using a pharmacological inhibitor of ferroptosis in a mouse model of BCP. L
Externí odkaz:
https://doaj.org/article/5b9a6a8dc60d4bbf9f76242de8519c4c
Autor:
Christina Wolf, Rahel Zimmermann, Osamah Thaher, Diones Bueno, Verena Wüllner, Michael K.E. Schäfer, Philipp Albrecht, Axel Methner
Publikováno v:
Cells, Vol 8, Iss 10, p 1289 (2019)
Charcot−Marie tooth disease is a hereditary polyneuropathy caused by mutations in Mitofusin-2 (MFN2), a GTPase in the outer mitochondrial membrane involved in the regulation of mitochondrial fusion and bioenergetics. Autosomal-dominant inheritance
Externí odkaz:
https://doaj.org/article/94d43432897b444986c8665715e6fe26
Autor:
Michael K.E. Schäfer, Yun-Chung Nam, Anice Moumen, Laura Keglowich, Elisabeth Bouché, Mercedes Küffner, Hans H. Bock, Fritz G. Rathjen, Cedric Raoul, Michael Frotscher
Publikováno v:
Neurobiology of Disease, Vol 40, Iss 1, Pp 222-237 (2010)
Mutations in the human L1CAM gene cause neurodevelopmental disorders collectively referred to as L1 syndrome. Here, we investigated cellular pathomechanisms underlying two L1 syndrome mutations, R184Q and W1036L. We demonstrate that these mutations c
Externí odkaz:
https://doaj.org/article/16e4986613644524ab5c65c5b266725c
Autor:
Yong Wang, Isa Wernersbach, Jenny Strehle, Shuailong Li, Dominik Appel, Matthias Klein, Katharina Ritter, Regina Hummel, Irmgard Tegeder, Michael K.E. Schäfer
Publikováno v:
Brain, Behavior, and Immunity. 106:49-66
There is a need for early therapeutic interventions after traumatic brain injury (TBI) to prevent neurodegeneration. Microglia/macrophage (M/M) depletion and repopulation after treatment with colony stimulating factor 1 receptor (CSF1R) inhibitors re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74f04663d1b53a4a9d0d09e730201b1
https://doi.org/10.1016/j.bbi.2022.07.164
https://doi.org/10.1016/j.bbi.2022.07.164
Autor:
Tobias J. Krämer, Per Hübener, Bruno Pöttker, Christina Gölz, Axel Neulen, Tobias Pantel, Hermann Goetz, Katharina Ritter, Serge C Thal, Michael K.E. Schäfer
Traumatic brain injury (TBI) involves primary mechanical damage and delayed secondary damage caused by vascular dysfunction and neuroinflammation. Intracellular components released into the parenchyma and systemic circulation, termed danger-associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67d9ac07b0b9290472232f163979c54b
https://doi.org/10.21203/rs.3.rs-956514/v1
https://doi.org/10.21203/rs.3.rs-956514/v1
Autor:
Diones Bueno, Partha Narayan Dey, Teresa Schacht, Christina Wolf, Verena Wüllner, Elena Morpurgo, Liliana Rojas-Charry, Lena Sessinghaus, Petra Leukel, Clemens Sommer, Konstantin Radyushkin, Michael K.E. Schäfer, Luise Florin, Jan Baumgart, Paul Stamm, Andreas Daiber, Guilherme Horta, Leonardo Nardi, Verica Vasic, Michael J. Schmeisser, Andrea Hellwig, Angela Oskamp, Andreas Bauer, Ruchika Anand, Andreas S. Reichert, Sandra Ritz, Gianluigi Nocera, Claire Jacob, Jonas Peper, Marion Silies, Katrin B. M. Frauenknecht, Axel Methner
Publikováno v:
bioRxiv beta (2021). doi:10.1101/2021.02.15.431234
Synaptic signaling depends on ATP generated by mitochondria. Due to extensive connectivity, the striatum is especially vulnerable to mitochondrial dysfunction and thus requires efficient mitochondrial quality control. We found that the neuronal calci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123703cc702ef41157238c13c03b5664
https://doi.org/10.1101/2021.02.15.431234
https://doi.org/10.1101/2021.02.15.431234