Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michael K.C. Lee"'
Autor:
Julia R. Naso, James T. Topham, Joanna M. Karasinska, Michael K.C. Lee, Steve E. Kalloger, Hui‐li Wong, Jessica Nelson, Richard A. Moore, Andrew J. Mungall, Steven J.M. Jones, Janessa Laskin, Marco A. Marra, Daniel J. Renouf, David F. Schaeffer
Publikováno v:
Cancer Medicine, Vol 10, Iss 3, Pp 1155-1165 (2021)
ABSTRACT Background RNA‐sequencing‐based classifiers can stratify pancreatic ductal adenocarcinoma (PDAC) into prognostically significant subgroups but are not practical for use in clinical workflows. Here, we assess whether histomorphological fe
Externí odkaz:
https://doaj.org/article/a9eff83f544e44f7a8c96d5e8aef3b2f
Autor:
Daniel J. Renouf, David F. Schaeffer, Steven J.M. Jones, Marco A. Marra, Janessa Laskin, Dixie L. Mager, Jonathan M. Loree, Steven Gallinger, Jennifer J. Knox, Grainne M. O'Kane, Andrew J. Mungall, Richard A. Moore, Hui-Li Wong, Steve E. Kalloger, Gun-Ho Jang, Robert E. Denroche, Shehara Mendis, Michael K.C. Lee, Luka Culibrk, Joanna M. Karasinska, Laura M. Williamson, Erin D. Pleasance, Emma Titmuss, James T. Topham
Supplemental Table S1 lists clinical characteristics for the study cohort. Figure S1 depicts results of batch correction. Figures S2 and S3 show comparisons between ERV levels and tumor content. Figure S4 shows ERV levels across different biopsy site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b69f9ec9320b0f02c755f4920338202
https://doi.org/10.1158/1535-7163.22520700
https://doi.org/10.1158/1535-7163.22520700
Autor:
Daniel J. Renouf, David F. Schaeffer, Steven J.M. Jones, Marco A. Marra, Janessa Laskin, Dixie L. Mager, Jonathan M. Loree, Steven Gallinger, Jennifer J. Knox, Grainne M. O'Kane, Andrew J. Mungall, Richard A. Moore, Hui-Li Wong, Steve E. Kalloger, Gun-Ho Jang, Robert E. Denroche, Shehara Mendis, Michael K.C. Lee, Luka Culibrk, Joanna M. Karasinska, Laura M. Williamson, Erin D. Pleasance, Emma Titmuss, James T. Topham
Supplemental Table S3 lists gene sets significantly enriched among genes up-regulated in VMP samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c5d9e0b10580a42fe778e509ce4a7f
https://doi.org/10.1158/1535-7163.22520709
https://doi.org/10.1158/1535-7163.22520709
Autor:
Daniel J. Renouf, David F. Schaeffer, Steven J.M. Jones, Marco A. Marra, Janessa Laskin, Dixie L. Mager, Jonathan M. Loree, Steven Gallinger, Jennifer J. Knox, Grainne M. O'Kane, Andrew J. Mungall, Richard A. Moore, Hui-Li Wong, Steve E. Kalloger, Gun-Ho Jang, Robert E. Denroche, Shehara Mendis, Michael K.C. Lee, Luka Culibrk, Joanna M. Karasinska, Laura M. Williamson, Erin D. Pleasance, Emma Titmuss, James T. Topham
Next-generation sequencing of solid tumors has revealed variable signatures of immunogenicity across tumors, but underlying molecular characteristics driving such variation are not fully understood. Although expression of endogenous retrovirus (ERV)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1892b88a5aa567d4d7a622d61e3a40
https://doi.org/10.1158/1535-7163.c.6542730
https://doi.org/10.1158/1535-7163.c.6542730
Autor:
Daniel J. Renouf, David F. Schaeffer, Steven J.M. Jones, Marco A. Marra, Janessa Laskin, Dixie L. Mager, Jonathan M. Loree, Steven Gallinger, Jennifer J. Knox, Grainne M. O'Kane, Andrew J. Mungall, Richard A. Moore, Hui-Li Wong, Steve E. Kalloger, Gun-Ho Jang, Robert E. Denroche, Shehara Mendis, Michael K.C. Lee, Luka Culibrk, Joanna M. Karasinska, Laura M. Williamson, Erin D. Pleasance, Emma Titmuss, James T. Topham
Supplemental Table S4 lists gene sets significantly enriched among genes down-regulated in VMP samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1854e1ebd87c639134037f464474948
https://doi.org/10.1158/1535-7163.22520706.v1
https://doi.org/10.1158/1535-7163.22520706.v1
Autor:
Daniel J. Renouf, David F. Schaeffer, Steven J.M. Jones, Marco A. Marra, Janessa Laskin, Dixie L. Mager, Jonathan M. Loree, Steven Gallinger, Jennifer J. Knox, Grainne M. O'Kane, Andrew J. Mungall, Richard A. Moore, Hui-Li Wong, Steve E. Kalloger, Gun-Ho Jang, Robert E. Denroche, Shehara Mendis, Michael K.C. Lee, Luka Culibrk, Joanna M. Karasinska, Laura M. Williamson, Erin D. Pleasance, Emma Titmuss, James T. Topham
Supplemental Table S5 lists EGA accession numbers for each sample included in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abc79eab609637e38d770f51efd2c3f
https://doi.org/10.1158/1535-7163.22520703.v1
https://doi.org/10.1158/1535-7163.22520703.v1
Autor:
Daniel J. Renouf, David F. Schaeffer, Steven J.M. Jones, Marco A. Marra, Janessa Laskin, Dixie L. Mager, Jonathan M. Loree, Steven Gallinger, Jennifer J. Knox, Grainne M. O'Kane, Andrew J. Mungall, Richard A. Moore, Hui-Li Wong, Steve E. Kalloger, Gun-Ho Jang, Robert E. Denroche, Shehara Mendis, Michael K.C. Lee, Luka Culibrk, Joanna M. Karasinska, Laura M. Williamson, Erin D. Pleasance, Emma Titmuss, James T. Topham
Supplemental Table S2 lists all genes differentially expressed in VMP samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af3bfb91cf5603c89826b619353b861
https://doi.org/10.1158/1535-7163.22520697
https://doi.org/10.1158/1535-7163.22520697
Autor:
David F. Schaeffer, Daniel J. Renouf, Steven J.M. Jones, Marco A. Marra, Janessa Laskin, Steven Gallinger, Jennifer J. Knox, Faiyaz Notta, Andrew Metcalfe, Cassia Warren, Malcolm J. Moore, Andrew J. Mungall, Richard A. Moore, Grainne M. O'Kane, Michael K.C. Lee, Hui-Li Wong, Laura M. Williamson, Luka Culibrk, Robert E. Denroche, Gun Ho Jang, Steve E. Kalloger, James T. Topham, Joanna M. Karasinska
Heatmap showing median gene expression levels (z-score) of genes involved in various pathways related to cellular metabolism. For each gene, within each of the four metabolic subgroups, expression values were assessed for significant deviation from z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255304b0b5735c553afac65d00b14af1
https://doi.org/10.1158/1078-0432.22474190.v1
https://doi.org/10.1158/1078-0432.22474190.v1
Autor:
David F. Schaeffer, Daniel J. Renouf, Steven J.M. Jones, Marco A. Marra, Janessa Laskin, Steven Gallinger, Jennifer J. Knox, Rachel Goodwin, Patricia A. Tang, Oliver Bathe, Julie M. Wilson, Jonathan M. Loree, Faiyaz Notta, Andrew J. Mungall, Richard A. Moore, Grainne M. O'Kane, Hui-li Wong, Steve E. Kalloger, Erica S. Tsang, Robert E. Denroche, Gun Ho Jang, Laura M. Williamson, Veronika Csizmok, Michael K.C. Lee, Joanna M. Karasinska, James T. Topham
Supplementary Figures S1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1655c83d1270b72909334a2dffd3e08
https://doi.org/10.1158/1078-0432.22478148.v1
https://doi.org/10.1158/1078-0432.22478148.v1
Autor:
David F. Schaeffer, Daniel J. Renouf, Steven J.M. Jones, Marco A. Marra, Janessa Laskin, Steven Gallinger, Jennifer J. Knox, Rachel Goodwin, Patricia A. Tang, Oliver Bathe, Julie M. Wilson, Jonathan M. Loree, Faiyaz Notta, Andrew J. Mungall, Richard A. Moore, Grainne M. O'Kane, Hui-li Wong, Steve E. Kalloger, Erica S. Tsang, Robert E. Denroche, Gun Ho Jang, Laura M. Williamson, Veronika Csizmok, Michael K.C. Lee, Joanna M. Karasinska, James T. Topham
Purpose:RNA-sequencing–based subtyping of pancreatic ductal adenocarcinoma (PDAC) has been reported by multiple research groups, each using different methodologies and patient cohorts. “Classical” and “basal-like” PDAC subtypes are associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698255a822eba90ef9bb69b8ad4f2aeb
https://doi.org/10.1158/1078-0432.c.6529866.v1
https://doi.org/10.1158/1078-0432.c.6529866.v1