Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michael K. Manion"'
Autor:
David M. Hockenbery, Ian R. Sweet, Craig M. Schulz, John S. Fry, Christine B. Emerson, Michael K. Manion, Pamela S. Schwartz
Adobe PDF - MCT-06-0767--Suppl_Materials.pdf from 2-Methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6a855aa21ac23d1879febf5aeea367
https://doi.org/10.1158/1535-7163.22487025
https://doi.org/10.1158/1535-7163.22487025
Autor:
David M. Hockenbery, Ian R. Sweet, Craig M. Schulz, John S. Fry, Christine B. Emerson, Michael K. Manion, Pamela S. Schwartz
Overexpression of Bcl-xL in multiple cancers correlates with resistance to chemotherapy and radiation therapy, and provides a rationale for development of small-molecule Bcl-xL inhibitors. Based on knockout studies, nonneoplastic cells also require B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b396726b338a26f4e93302297966f5f
https://doi.org/10.1158/1535-7163.c.6532440.v1
https://doi.org/10.1158/1535-7163.c.6532440.v1
Autor:
Christine B. Emerson, Pamela S. Schwartz, Michael K. Manion, Ian R. Sweet, David M. Hockenbery, John S. Fry, Craig M. Schulz
Publikováno v:
Molecular Cancer Therapeutics. 6:2073-2080
Overexpression of Bcl-xL in multiple cancers correlates with resistance to chemotherapy and radiation therapy, and provides a rationale for development of small-molecule Bcl-xL inhibitors. Based on knockout studies, nonneoplastic cells also require B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ef23b0cfda071308facc230be5c351
https://doi.org/10.1158/1535-7163.mct-06-0767
https://doi.org/10.1158/1535-7163.mct-06-0767
Publikováno v:
Scopus-Elsevier
Calmodulin (CaM), as well as other Ca2+ binding motifs (i.e., EF hands), have been demonstrated to be Ca2+ sensors for several ion channel types, usually resulting in an inactivation in a negative feedback manner. This provides a novel target for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ec647f09babc330389bbade5c7e381
https://doi.org/10.1096/fasebj.14.10.1297
https://doi.org/10.1096/fasebj.14.10.1297
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 7(12)
Cancer cells with elevated levels of Bcl-2 and the related anti-apoptotic proteins Bcl-x(L), Mcl-1 and Bcl-W are broadly resistant to standard anticancer drugs and other therapeutic modalities. Antisense oligodeoxynucleotides and, more recently, smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88dc19c067c54d1d3cba4bcec88d0591
https://pubmed.ncbi.nlm.nih.gov/17209525
https://pubmed.ncbi.nlm.nih.gov/17209525
Autor:
Holger A, Erxleben, Michael K, Manion, David M, Hockenbery, Louis, Scampavia, Jaromir, Ruzicka
Publikováno v:
The Analyst. 129(3)
Monitoring extracellular acidification rates (ECARs) is important for the study of cellular activities, since it allows for the evaluation of factors that alter metabolic function, such as stimulants, inhibitors, toxins as well as receptor and non-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cac6fb36a35291b2187aa939f15f2ee6
https://pubmed.ncbi.nlm.nih.gov/14978521
https://pubmed.ncbi.nlm.nih.gov/14978521
Autor:
Michael K, Manion, David M, Hockenbery
Publikováno v:
Cancer biologytherapy. 2(4 Suppl 1)
The BCL-2 family proteins are attractive targets for drug design. As pivotal regulators of apoptotic cell death, the logic of manipulating BCL-2 functions for anti-tumor effects is perhaps the strongest for any of the molecular targets proposed for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84974838d7053f30f87fbde292e86e74
https://pubmed.ncbi.nlm.nih.gov/14508087
https://pubmed.ncbi.nlm.nih.gov/14508087
Autor:
David M, Hockenbery, Christopher D, Giedt, Jason W, O'Neill, Michael K, Manion, Deborah E, Banker
Publikováno v:
Advances in cancer research. 85
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::856982f7270ed911a1a9e511fcd12f66
https://pubmed.ncbi.nlm.nih.gov/12374287
https://pubmed.ncbi.nlm.nih.gov/12374287
Autor:
Patricia L. Jackson, J. Edwin Blalock, Michael K. Manion, Ted T. Sakai, Tonny M. Johnson, Wen-Ji Dong, Giorgio Fassina, Matteo Villain, N. Rama Krishna, Zhengchang Su
Publikováno v:
The Journal of biological chemistry. 275(4)
This report describes the use of the concept of inversion of hydropathy patterns to the de novo design of peptides targeted to a predetermined site on a protein. Eight- and 12-residue peptides were constructed with the EF hands or Ca(2+)-coordinating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7343774b554d6f5ec063d86eef35985e
https://pubmed.ncbi.nlm.nih.gov/10644729
https://pubmed.ncbi.nlm.nih.gov/10644729