Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael K. James"'
Publikováno v:
Journal of Food Protection, Vol 87, Iss 7, Pp 100298- (2024)
Validation of baking processes for the inactivation of Salmonella is complicated by the combined effects of product heating and drying. The goal of this study was to quantitatively evaluate a previously disseminated approach to validating baking proc
Externí odkaz:
https://doaj.org/article/fd882dff42764c45917c429dfe33afe0
Publikováno v:
Journal of Food Protection. 84:1512-1523
Recent revisions to U.S. Department of Agriculture, Food Safety and Inspection Service (FSIS) compliance and safe harbor guidelines for ready-to-eat meat and poultry products addressed process humidity requirements. Given the lack of prior data for i
Publikováno v:
Journal of food protection. 82(2)
Salmonella survival and thermal resistance on the surface of almond kernels were evaluated after periods of storage. Almond kernels were inoculated with Salmonella Enteritidis PT 30 and equilibrated to 0.45 water activity. Samples were separated into
Autor:
Michael K. James, Elliot T. Ryser, Sarah E. Buchholz, Nicole O. Hall, Bradley P. Marks, Pichamon Limcharoenchat
Publikováno v:
Journal of food protection. 81(4)
Inoculation methods in pathogen inactivation studies ideally represent conditions that might occur in real-world scenarios. Surface contamination in or on low-moisture foods affects Salmonella thermal resistance, which is critically important for pro
Publikováno v:
Journal of food protection. 80(1)
Ongoing regulatory changes are increasing the need for reliable process validation methods for pathogen reduction processes involving low-moisture products; however, the reliability of various validation methods has not been evaluated. Therefore, the
Autor:
Mary K. Grizzle, L.S. Birkemo, Ronald George Sherrill, Milana Dezube, Elizabeth E. Sugg, Frank Vanmiddlesworth, Michael K. James, Judd Berman, Dallas K. Croom, Thomas J. Rimele, Michael F. Johnson, Kennedy L. Queen, Gregory N. Ervin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1145-1148
A series of 1,4-benzodiazepines, N-1-substituted with an N-isopropyl-N-phenylacetamide moiety, was synthesized and screened for CCK-A agonist activity. In vitro agonist activity on isolated guinea pig gallbladder along with in vivo induction of satie
Autor:
Elizabeth E. Sugg, Dallas K. Croom, Kennedy L. Queen, Edward Martin Suh, Rayomand J. Unwalla, Ronald George Sherrill, Michael K. James, Jeff Yingling, Gavin C. Hirst, Jerzy Szewczyk, Michael F. Johnson, Mary K. Grizzle, Christopher Joseph Aquino, Brad R. Henke, Larry S. Birkemo, Gregory N. Ervin, Robert W. Dougherty, Timothy M. Willson
Publikováno v:
Journal of Medicinal Chemistry. 40:2706-2725
We previously described a series of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepine CCK-A agonists exemplified by compound 1 (GW 5823), which is the first reported binding selective CCK-A full agonist demonstrating oral efficacy in a rat feeding model.
Autor:
Shaffer Christy L, Michael K James
Publikováno v:
Expert Opinion on Investigational Drugs. 5:1163-1171
Despite recent progress in determining the genetic basis of cystic fibrosis (CF), treatment of this disease is almost entirely based on antibiotic therapy to treat lung infections arising from viscous mucous and impaired mucociliary clearance. No tre
Autor:
Michael K. James, Elizabeth E. Sugg, Michael F. Johnson, Tanya M. Momtahen, Brad R. Henke, Timothy M. Willson, Dallas K. Croom, Jeff Yingling, Kennedy L. Queen, Robert W. Dougherty, Rayomand J. Unwalla, Peter L. Myers, Thomas J. Rimele, Mary K. Grizzle
Publikováno v:
Journal of Medicinal Chemistry. 39:3030-3034
A series of modifications were made to the C-3 substituent of the 1,5-benzodiazepine CCK-A agonist 1. Replacement of the inner urea NH and addition of a methyl group to generate a C-3 quaternary carbon resulted in acetamide 6, which showed CCK-A rece
Autor:
Christopher Joseph Aquino, Robert W. Dougherty, Judd Berman, Thomas J. Rimele, Michael F. Johnson, Larry S. Birkemo, Dallas K. Croom, Gavin C. Hirst, Armour Duncan Robert, Julie E. Head, Robin A. E. Carr, Milana Dezube, Laurence J. Miller, David N. Smith, Mary K. Grizzle, Gregory N. Ervin, Kennedy L. Queen, Elizabeth E. Sugg, Michael K. James
Publikováno v:
Journal of Medicinal Chemistry. 39:562-569
Directed screening of compounds selected from the Glaxo registry file for contractile activity on the isolated guinea pig gallbladder (GPGB) identified a series of 1,5-benzodiazepines with peripheral cholecystokinin (CCK) receptor agonist activity. A