Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michael K. Hilinski"'
Publikováno v:
ACS Catal
We introduce an organocatalytic approach for oxaziridinium-mediated C–H hydroxylation that employs secondary amines as catalysts. We also demonstrate the advantages of this operationally simple catalytic strategy for achieving high yielding and hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::492a7866f361cdc2bb41f3f73f500b87
https://pubmed.ncbi.nlm.nih.gov/35529672
https://pubmed.ncbi.nlm.nih.gov/35529672
Publikováno v:
ACS Catalysis. 12:4302-4309
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51fd9d4319ecb5af1d84ccdec8633f5b
https://doi.org/10.1021/acscatal.2c00392
https://doi.org/10.1021/acscatal.2c00392
Publikováno v:
Chemical Science
Described are the first examples of Lewis acid-promoted Diels–Alder reactions of vinylpyridines and other vinylazaarenes with unactivated dienes. Cyclohexyl-appended azaarenes constitute a class of substructures of rising prominence in drug discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8e13a62510911999ca959b46c66cc5
https://doi.org/10.1039/d1sc05095h
https://doi.org/10.1039/d1sc05095h
Publikováno v:
Organic Letters. 21:2307-2311
Formal [5+1] cycloadditions between aryl-substituted vinylcyclopropanes and nitrenoid precursors are reported. The method, which employs Rh(2)(esp)(2) as a catalyst, leads to the highly regioselective formation of substituted tetrahydropyridines. Pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f1e676ec0763318670166488d5f8a2
https://doi.org/10.1021/acs.orglett.9b00594
https://doi.org/10.1021/acs.orglett.9b00594
Publikováno v:
ACS Catal
Carbon-nitrogen bonds are extremely prevalent in pharmaceuticals, natural products, and other biologically relevant molecules such as nucleic acids and proteins. Intermolecular amination of C(sp(3))-H bonds by catalytic nitrene transfer is a promisin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45dcf221a134820eb204f21c0df60b04
https://europepmc.org/articles/PMC8188841/
https://europepmc.org/articles/PMC8188841/
Publikováno v:
Synlett. 29:2331-2336
Predictably site-selective catalytic methods for intermolecular C(sp3)–H hydroxylation and amination hold great promise for the synthesis and late-stage modification of complex molecules. Transition-metal catalysis has been the most common approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::559dc5f42fa510a7677670fdafc195d9
https://doi.org/10.1055/s-0037-1610432
https://doi.org/10.1055/s-0037-1610432
Publikováno v:
Organic Letters. 20:2011-2014
The first examples of nonenzymatic N-oxidation of heteroarenes in the presence of amines are reported. Pyridine, quinoline, and isoquinoline N-oxides are selectively formed in the presence of more reactive aliphatic and alicyclic amines by use of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f014fa4aec4d18d30447dbb341ecef6
https://doi.org/10.1021/acs.orglett.8b00558
https://doi.org/10.1021/acs.orglett.8b00558
Publikováno v:
Chemical Science. 9:935-939
This report details the first organocatalytic method for nitrenoid transfer and its application to intermolecular, site-selective C(sp3)–H amination. The method utilizes a trifluoromethyl iminium salt as the catalyst, iminoiodinanes as the nitrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baa19fd7e456636274d8af7c47d2dcd6
https://doi.org/10.1039/c7sc03968a
https://doi.org/10.1039/c7sc03968a
Publikováno v:
Organic Letters. 19:4790-4793
Dioxiranes are among the most selective and useful reagents for C(sp3)–H hydroxylation, but the development of a general dioxirane-mediated catalytic method has been an elusive goal. A trifluoromethyl ketone catalyst in combination with Oxone is sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699a5dd9c6f8588b4c1cb45f52b3a11b
https://doi.org/10.1021/acs.orglett.7b02178
https://doi.org/10.1021/acs.orglett.7b02178
Publikováno v:
Organicbiomolecular chemistry. 17(43)
Sc(OTf)3-promoted [5 + 1] cycloaddition of vinylcyclopropanes with PhINTs is reported, enabling the regioselective preparation of a range of 1,2,3,6-tetrahydropyridine scaffolds under mild conditions. This represents the second example of a [5 + 1] n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027195020c92afb2731d651ecc747aef
https://pubmed.ncbi.nlm.nih.gov/31641723
https://pubmed.ncbi.nlm.nih.gov/31641723