Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michael K. Hancock"'
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6871 (2009)
Type 2 diabetes develops due to a combination of insulin resistance and beta-cell failure and current therapeutics aim at both of these underlying causes. Several negative regulators of insulin signaling are known and are the subject of drug discover
Externí odkaz:
https://doaj.org/article/f363e6613ab2456cb69244476fca53ed
Publikováno v:
Current Chemical Genomics and Translational Medicine
Neurite outgrowth is an important morphological phenotype of neuronal cells that correlates with their function and cell health, yet there are limited methods available for measuring this phenomenon. Current approaches to measuring neurite outgrowth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1770d5cd7fd88992b14ad27f038a65d3
https://doi.org/10.2174/2213988501509010006
https://doi.org/10.2174/2213988501509010006
Autor:
Coby B. Carlson, Carole Crittenden, Oksana Sirenko, Michael K. Hancock, Grischa Chandy, Sean Keating, Matthew Hammer
Publikováno v:
Assay and drug development technologies. 15(6)
Development of more complex, biologically relevant, and predictive cell-based assays for compound screening is a major challenge in drug discovery. The focus of this study was to establish high-throughput compatible three-dimensional (3D) cardiotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724498d0f8caffa6e09a15e57140588d
https://pubmed.ncbi.nlm.nih.gov/28837356
https://pubmed.ncbi.nlm.nih.gov/28837356
Autor:
Coby B. Carlson, Michael K. Hancock, T.K. Feaster, David J. Mann, Natsuyo Aoyama, David Schlesinger, Blake D. Anson
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:162-163
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b029ff989327c0555fb8a914175d4dd0
https://doi.org/10.1016/j.vascn.2018.01.529
https://doi.org/10.1016/j.vascn.2018.01.529
Autor:
Coby B. Carlson, Avrum Cohen, Jayne Hesley, David A. Mann, Jason Gentry, Michael K. Hancock, Dihui Hong, Oksana Sirenko
Publikováno v:
Assay and Drug Development Technologies
Cell models are becoming more complex to better mimic the in vivo environment and provide greater predictivity for compound efficacy and toxicity. There is an increasing interest in exploring the use of three-dimensional (3D) spheroids for modeling d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84e07a1ee439c005604b58cfeff8f94
https://pubmed.ncbi.nlm.nih.gov/27494736
https://pubmed.ncbi.nlm.nih.gov/27494736
Publikováno v:
Autophagy. 8:1227-1244
Autophagy involves the isolation and targeting of unwanted cellular components to lysosomes for their digestion and reuse. Autophagic dysregulation has recently been implicated in a wide range of disease processes, yet facile methods for quantifying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6a21238e133d09f700f4b00b8b3ea4
https://doi.org/10.4161/auto.20441
https://doi.org/10.4161/auto.20441
Autor:
Kun Bi, Paula Harrison, Michael K. Hancock, Tristan J. Vaughan, John Andrews, Alison J. Smith
Publikováno v:
SLAS Discovery. 17:713-726
Implementing functional cell-based screens in early antibody discovery has become increasingly important to select antibodies with the desired profile. However, this is limited by assay tolerance to crude antibody preparations and assay sensitivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1cd7ce5e3f5db1249e43ba7e5241561
https://doi.org/10.1177/1087057112442962
https://doi.org/10.1177/1087057112442962
Publikováno v:
Current Chemical Genomics
Trk receptor tyrosine kinases are required for signal transduction initiated by neurotrophins leading to cell proliferation, differentiation, survival and death. Alterations in Trk kinase activity have been linked to various diseases. To address the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbacf3b11690d36c3748866d58298ce
http://europepmc.org/articles/PMC2774616
http://europepmc.org/articles/PMC2774616
Autor:
Connie S. Lebakken, Kaitlyn Vandenheuvel-Kramer, Andrew L. Kopp, Jasmin R. Gibson, Tina M. Hallis, Tammy Turek-Etienne, Michael K. Hancock
Publikováno v:
SLAS Discovery. 12:635-644
A problem inherent to the use of cellular assays for drug discovery is their sensitivity to cytotoxic compounds, which can result in false hits from certain compound screens. To alleviate the need to follow-up hits from a reporter assay with a separa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08aad48717dd44d80a38293578cbeb2f
https://doi.org/10.1177/1087057107301499
https://doi.org/10.1177/1087057107301499
Autor:
Bonnie J. Hanson, Michael K. Hancock
Publikováno v:
Neural Stem Cell Assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa201f8d38a66ee8fdceed4e24183429
https://doi.org/10.1002/9781118308295.ch16
https://doi.org/10.1002/9781118308295.ch16
