Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Michael K Swan"'
Autor:
Rodrigo Vasquez-Del Carpio, Timothy D Silverstein, Samer Lone, Michael K Swan, Jayati R Choudhury, Robert E Johnson, Satya Prakash, Louise Prakash, Aneel K Aggarwal
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5766 (2009)
BACKGROUND:Oxygen-free radicals formed during normal aerobic cellular metabolism attack bases in DNA and 7,8-dihydro-8-oxoguanine (8-oxoG) is one of the major lesions formed. It is amongst the most mutagenic lesions in cells because of its dual codin
Externí odkaz:
https://doaj.org/article/4b1d6331eec7450fa5120fa3b21c251e
Autor:
Michael K. Swan, Mike John Latchem, Dean Boyall, Stuart W. Hughes, Julie Anne Christine Alexandre, John Pollard, James Westcott
Publikováno v:
ChemBioChem. 19:552-561
Indoleamine-2,3 dioxygenase 1 (IDO1) has emerged as a central regulator of immune responses in both normal and disease biology. Due to its established role in promoting tumour immune escape, IDO1 has become an attractive target for cancer treatment.
Autor:
Peter A. Charlton, Valerie Legris, John Pollard, Philip Michael Reaper, Jay A. Bertrand, Golec Julian M C, Sarah Vial, Michael K. Swan, Rebecca Bordas, Adam Tanner
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 70:1465-1475
Bloom's syndrome is an autosomal recessive genome-instability disorder associated with a predisposition to cancer, premature aging and developmental abnormalities. It is caused by mutations that inactivate the DNA helicase activity of the BLM protein
Autor:
John Pollard, Michael K. Swan, Stuart W. Hughes, Julie Anne Christine Alexandre, James Westcott, Dean Boyall, Mike John Latchem
Publikováno v:
ChemBioChem. 19:528-528
Publikováno v:
Nature structural & molecular biology
DNA polymerase δ (Polδ) is a high fidelity polymerase that plays a central role in replication from yeast to humans. We present here the crystal structure of the catalytic subunit of yeast Polδ in ternary complex with a template-primer and an inco
Publikováno v:
Proceedings of the National Academy of Sciences. 103:18481-18486
We have determined the crystal structure of a monomeric biologically active form of the pi initiator protein of plasmid R6K as a complex with a single copy of its cognate DNA-binding site (iteron) at 3.1-A resolution. The initiator belongs to the fam
Publikováno v:
Journal of Biological Chemistry. 279:39838-39845
The crystal structure of a dual specificity phosphoglucose isomerase (PGI)/phosphomannose isomerase from Pyrobaculum aerophilum (PaPGI/PMI) has been determined in native form at 1.16-A resolution and in complex with the enzyme inhibitor 5-phosphoarab
Autor:
Thomas Hansen, Michael K. Swan, Christopher Davies, Craig Beeson, Peter Schönheit, J. T. Graham Solomons
Publikováno v:
Journal of Biological Chemistry. 278:47261-47268
In the Euryarchaeota species Pyrococcus furiosus and Thermococcus litoralis, phosphoglucose isomerase (PGI) activity is catalyzed by an enzyme unrelated to the well known family of PGI enzymes found in prokaryotes, eukaryotes, and some archaea. We ha
Publikováno v:
Protein & Peptide Letters. 10:517-520
In several euryarchaeota, phosphoglucose isomerase (PGI) activity is catalyzed by an enzyme unrelated to the well-known family of PGI enzymes found in prokaryotes, eukaryotes and some archaea. In order to understand the mechanistic differences betwee
Comparing the Success of Students Enrolled in Distance Education Courses vs. Face–to–Face Classrooms
Autor:
Michael K. Swan, Diane H. Jackman
Publikováno v:
Journal of Technology Studies. 26:58-63