Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael K Scales"'
Autor:
Michael K Scales, Ashley Velez-Delgado, Nina G Steele, Hannah E Schrader, Anna M Stabnick, Wei Yan, Nayanna M Mercado Soto, Zeribe C Nwosu, Craig Johnson, Yaqing Zhang, Daniel J Salas-Escabillas, Rosa E Menjivar, H Carlo Maurer, Howard C Crawford, Filip Bednar, Kenneth P Olive, Marina Pasca di Magliano, Benjamin L Allen
Publikováno v:
PLoS Genetics, Vol 18, Iss 7, p e1010315 (2022)
Proper Hedgehog (HH) signaling is essential for embryonic development, while aberrant HH signaling drives pediatric and adult cancers. HH signaling is frequently dysregulated in pancreatic cancer, yet its role remains controversial, with both tumor-p
Externí odkaz:
https://doaj.org/article/eaf83723636e457b88ff374b523b3867
Autor:
Michael W Susman, Edith P Karuna, Ryan C Kunz, Taranjit S Gujral, Andrea V Cantú, Shannon S Choi, Brigette Y Jong, Kyoko Okada, Michael K Scales, Jennie Hum, Linda S Hu, Marc W Kirschner, Ryuichi Nishinakamura, Soichiro Yamada, Diana J Laird, Li-En Jao, Steven P Gygi, Michael E Greenberg, Hsin-Yi Henry Ho
Publikováno v:
eLife, Vol 6 (2017)
Wnt5a-Ror signaling constitutes a developmental pathway crucial for embryonic tissue morphogenesis, reproduction and adult tissue regeneration, yet the molecular mechanisms by which the Wnt5a-Ror pathway mediates these processes are largely unknown.
Externí odkaz:
https://doaj.org/article/275601caa693448db8ac74e33e0585f8
Autor:
Ashley Velez-Delgado, Katelyn L. Donahue, Kristee L. Brown, Wenting Du, Valerie Irizarry-Negron, Rosa E. Menjivar, Emily L. Lasse Opsahl, Nina G. Steele, Stephanie The, Jenny Lazarus, Veerin R. Sirihorachai, Wei Yan, Samantha B. Kemp, Samuel A. Kerk, Murali Bollampally, Sion Yang, Michael K. Scales, Faith R. Avritt, Fatima Lima, Costas A. Lyssiotis, Arvind Rao, Howard C. Crawford, Filip Bednar, Timothy L. Frankel, Benjamin L. Allen, Yaqing Zhang, Marina Pasca di Magliano
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology. 13:1673-1699
Oncogenic Kirsten Rat Sarcoma virus (KRAS) is the hallmark mutation of human pancreatic cancer and a driver of tumorigenesis in genetically engineered mouse models of the disease. Although the tumor cell-intrinsic effects of oncogenic Kras expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29221b6c6332ffd50a7697da8fc55df1
https://doi.org/10.1016/j.jcmgh.2022.02.016
https://doi.org/10.1016/j.jcmgh.2022.02.016
Autor:
Marina Pasca di Magliano, Ben L. Allen, Filip Bednar, Hui-Ju Wen, Yaqing Zhang, Paloma E. Garcia, Howard C. Crawford, Michael K. Scales, Amara Z. Shaikh, Esther Kim, Yara S. El-Tawil, Maeva Adoumie, Deneen M. Wellik
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 581-599 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 581-599 (2020)
Background & Aims Although the healthy pancreas consists mostly of epithelial cells, pancreatic cancer and the precursor lesions known as pancreatic intraepithelial neoplasia, are characterized by an extensive accumulation of fibroinflammatory stroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bb9a4858459dea9c49e9fd7caeb3bb
http://europepmc.org/articles/PMC7399194
http://europepmc.org/articles/PMC7399194
Autor:
Hsin-Yi Henry Ho, Shannon S. Choi, Michael K Scales, Srisathya Srinivasan, Kyoko Okada, Helen Lamb, Michael W. Susman, Sara E.Konopelski Snavely, Steven P. Gygi, Ryan C. Kunz, Edith P. Karuna, Michael X Cohen, Jia Tan, Michael E. Greenberg
Publikováno v:
Proc Natl Acad Sci U S A
Wnt5a-Ror signaling is a conserved pathway that regulates morphogenetic processes during vertebrate development [R. T. Moon et al., Development 119, 97–111 (1993); I. Oishi et al., Genes Cells 8, 645–654 (2003)], but its downstream signaling even
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2824d8cb1f62d235cad3200beb45f7ca
https://pubmed.ncbi.nlm.nih.gov/34135125
https://pubmed.ncbi.nlm.nih.gov/34135125
Autor:
Sara E. Konopelski Snavely, Michael W. Susman, Ryan C. Kunz, Jia Tan, Srisathya Srinivasan, Michael D. Cohen, Kyoko Okada, Helen Lamb, Shannon S. Choi, Edith P. Karuna, Michael K. Scales, Steven P. Gygi, Michael E. Greenberg, Hsin-Yi Henry Ho
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 25
Wnt5a-Ror signaling is a conserved pathway that regulates morphogenetic processes during vertebrate development [R. T. Moon et al, Development 119, 97-111 (1993); I. Oishi et al, Genes Cells 8, 645-654 (2003)], but its downstream signaling events rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685abbc48f6569680df2d03a3730d6a1
https://doi.org/10.1101/2020.06.22.163790
https://doi.org/10.1101/2020.06.22.163790
Publikováno v:
Cells, Vol 9, Iss 2464, p 2464 (2020)
Cells
Cells
Pancreatic ductal adenocarcinoma (PDA) is characterized by an extensive fibroinflammatory microenvironment that accumulates from the onset of disease progression. Cancer-associated fibroblasts (CAFs) are a prominent cellular component of the stroma,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8360811a7150f815305b8a397c07fc
https://doi.org/10.3390/cells9112464
https://doi.org/10.3390/cells9112464
Autor:
Michael E. Greenberg, Michael W. Susman, Shannon S. Choi, Helen Lamb, Kyoko Okada, Jia Tan, Steven P. Gygi, Michael K Scales, Ryan C. Kunz, Edith P. Karuna, Henry Ho, Sara E. Konopelski, Michael S. Cohen
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52c167db60d2e9a50c15f82b97ca4942
https://doi.org/10.1096/fasebj.2020.34.s1.00207
https://doi.org/10.1096/fasebj.2020.34.s1.00207
Autor:
Michael K Scales, Jennie Hum, Michael X Cohen, Edith P. Karuna, Fernando A. Fierro, Hsin-Yi Henry Ho, Shannon S. Choi
Publikováno v:
Genes, vol 9, iss 4
Genes, Vol 9, Iss 4, p 196 (2018)
Genes
Genes; Volume 9; Issue 4; Pages: 196
Genes, Vol 9, Iss 4, p 196 (2018)
Genes
Genes; Volume 9; Issue 4; Pages: 196
Noncanonical WNT pathways function independently of the β-catenin transcriptional co-activator to regulate diverse morphogenetic and pathogenic processes. Recent studies showed that noncanonical WNTs, such as WNT5A, can signal the degradation of sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90d28b0857a571f99872b65d2e41bff
https://escholarship.org/uc/item/2f99p334
https://escholarship.org/uc/item/2f99p334
Autor:
Hsin-Yi Henry Ho, Ryan C. Kunz, Michael K Scales, Ryuichi Nishinakamura, Shannon S. Choi, Taranjit S. Gujral, Li-En Jao, Jennie Hum, Soichiro Yamada, Kyoko Okada, Andrea V. Cantú, Steven P. Gygi, Diana J. Laird, Edith P. Karuna, Brigette Y Jong, Michael E. Greenberg, Linda Hu, Michael W. Susman, Marc W. Kirschner
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Wnt5a-Ror signaling constitutes a developmental pathway crucial for embryonic tissue morphogenesis, reproduction and adult tissue regeneration, yet the molecular mechanisms by which the Wnt5a-Ror pathway mediates these processes are largely unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b4bb8ddca231c195cf545fe06b7db0
http://europepmc.org/articles/PMC5590807
http://europepmc.org/articles/PMC5590807