Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Michael K Rosen"'
Autor:
Carlos M Roggero, Victoria Esser, Lingling Duan, Allyson M Rice, Shihong Ma, Ganesh V Raj, Michael K Rosen, Zhi-Ping Liu, Josep Rizo
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0258876 (2022)
The androgen receptor (AR) plays a central role in prostate cancer. Development of castration resistant prostate cancer (CRPC) requires androgen-independent activation of AR, which involves its large N-terminal domain (NTD) and entails extensive epig
Externí odkaz:
https://doaj.org/article/ae2ec9b77d914be58c7a3ff32e1967ce
Publikováno v:
eLife, Vol 11 (2022)
Integrin adhesion complexes (IACs) are integrin-based plasma-membrane-associated compartments where cells sense environmental cues. The physical mechanisms and molecular interactions that mediate initial IAC formation are unclear. We found that both
Externí odkaz:
https://doaj.org/article/89f3720a16684f918e7526cf4a8e10bc
Autor:
Vladimir Zhemkov, Jonathon A Ditlev, Wan-Ru Lee, Mikaela Wilson, Jen Liou, Michael K Rosen, Ilya Bezprozvanny
Publikováno v:
eLife, Vol 10 (2021)
Sigma 1 receptor (S1R) is a 223-amino-acid-long transmembrane endoplasmic reticulum (ER) protein. S1R modulates activity of multiple effector proteins and is a well-established drug target. However, signaling functions of S1R in cells are poorly unde
Externí odkaz:
https://doaj.org/article/151f396a8d22489085371cbc83db875d
Publikováno v:
eLife, Vol 9 (2020)
P bodies are archetypal biomolecular condensates that concentrate proteins and RNA without a surrounding membrane. While dozens of P body proteins are known, the concentrations of components in the compartment have not been measured. We used live cel
Externí odkaz:
https://doaj.org/article/9a1ef30d03f24323ac2bd90b87114776
Autor:
Jonathon A Ditlev, Anthony R Vega, Darius Vasco Köster, Xiaolei Su, Tomomi Tani, Ashley M Lakoduk, Ronald D Vale, Satyajit Mayor, Khuloud Jaqaman, Michael K Rosen
Publikováno v:
eLife, Vol 8 (2019)
During T cell activation, biomolecular condensates form at the immunological synapse (IS) through multivalency-driven phase separation of LAT, Grb2, Sos1, SLP-76, Nck, and WASP. These condensates move radially at the IS, traversing successive radiall
Externí odkaz:
https://doaj.org/article/4967687a42254a76a7c714088eb669a4
Publikováno v:
eLife, Vol 6 (2017)
Phase transitions of linear multivalent proteins control the reversible formation of many intracellular membraneless bodies. Specific non-covalent crosslinks involving domains/motifs lead to system-spanning networks referred to as gels. Gelation tran
Externí odkaz:
https://doaj.org/article/9e4e7d6cb7f54e61ade9e5571082a0f2
Autor:
Baoyu Chen, Hui-Ting Chou, Chad A Brautigam, Wenmin Xing, Sheng Yang, Lisa Henry, Lynda K Doolittle, Thomas Walz, Michael K Rosen
Publikováno v:
eLife, Vol 6 (2017)
The Rho GTPase Rac1 activates the WAVE regulatory complex (WRC) to drive Arp2/3 complex-mediated actin polymerization, which underpins diverse cellular processes. Here we report the structure of a WRC-Rac1 complex determined by cryo-electron microsco
Externí odkaz:
https://doaj.org/article/d8f2a102fa8b48d786f9e435625e56f9
Autor:
Naren Srinivasan, Oliver Gordon, Susan Ahrens, Anna Franz, Safia Deddouche, Probir Chakravarty, David Phillips, Ali A Yunus, Michael K Rosen, Rita S Valente, Luis Teixeira, Barry Thompson, Marc S Dionne, Will Wood, Caetano Reis e Sousa
Publikováno v:
eLife, Vol 5 (2016)
Damage-associated molecular patterns (DAMPs) are molecules released by dead cells that trigger sterile inflammation and, in vertebrates, adaptive immunity. Actin is a DAMP detected in mammals by the receptor, DNGR-1, expressed by dendritic cells (DCs
Externí odkaz:
https://doaj.org/article/fe2f27a79c6945b9a55b17fd85b0bd6b
Autor:
Sudeep Banjade, Michael K Rosen
Publikováno v:
eLife, Vol 3 (2014)
Clustering of proteins into micrometer-sized structures at membranes is observed in many signaling pathways. Most models of clustering are specific to particular systems, and relationships between physical properties of the clusters and their molecul
Externí odkaz:
https://doaj.org/article/2cf994229bf94f928a54d1c388b4cdfa
Autor:
Benjamin A Smith, Shae B Padrick, Lynda K Doolittle, Karen Daugherty-Clarke, Ivan R Corrêa Jr, Ming-Qun Xu, Bruce L Goode, Michael K Rosen, Jeff Gelles
Publikováno v:
eLife, Vol 2 (2013)
During cell locomotion and endocytosis, membrane-tethered WASP proteins stimulate actin filament nucleation by the Arp2/3 complex. This process generates highly branched arrays of filaments that grow toward the membrane to which they are tethered, a
Externí odkaz:
https://doaj.org/article/101ba6f4735146f682e1059f11779d6f