Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Michael K Pugsley"'
Autor:
Elisa Vega-Avila, Michael K Pugsley
Publikováno v:
International Journal of Basic Science in Medicine, Vol 2, Iss 2, Pp 73-76 (2017)
Externí odkaz:
https://doaj.org/article/681585c3ee4d416dad5d6ce71600f417
Autor:
Alykhan Devsi, Brett Kiyota, Theophile Ouellette, Andrew P. Hegle, Ricardo E. Rivera-Acevedo, Jasper Wong, Ying Dong, Michael K. Pugsley, Timothy Fung
Publikováno v:
Journal of Cannabis Research, Vol 2, Iss 1, Pp 1-13 (2020)
Abstract Background Cannabis contains Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) as the primary constituents responsible for pharmacological activity. However, there are numerous additional chemically-related structures to Δ9–THC and
Externí odkaz:
https://doaj.org/article/0f40c0572a86470ea9021c4c43b760cb
Autor:
David Jones, William J. Brock, Stephanie N Harris, Simon Authier, Wendy G. Halpern, Michael K. Pugsley, Timothy J. McGovern, Pamela D McGovern
Publikováno v:
International Journal of Toxicology. 40:487-505
The growth in drug development over the past years reflects significant advancements in basic sciences and a greater understanding of molecular pathways of disease. Benchmarking industry practices has been important to enable a critical reflection on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c900297e24b5839cdb9dfacb4ba3999f
https://doi.org/10.1177/10915818211043435
https://doi.org/10.1177/10915818211043435
Autor:
Michael K. Pugsley, Yevgeniya E. Koshman, Tessa de Korte, Simon Authier, Brett R. Winters, Michael J. Curtis
Publikováno v:
Journal of pharmacological and toxicological methods. 117
The 2021 Annual Safety Pharmacology (SP) Society (SPS) meeting was held virtually October 4-8, 2021 due to the continuing COVID-19 global pandemic. This themed issue of J Pharmacol Toxicol Methods comprises articles arising from the meeting. As in pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f229c5619621ec48234420e4758f885
https://pubmed.ncbi.nlm.nih.gov/35926772
https://pubmed.ncbi.nlm.nih.gov/35926772
Autor:
Emmanuel Boulay, Loïs S. Miraucourt, Michael K. Pugsley, Matthew M. Abernathy, Ray Chui, Jill Dalton, Marjorie Demers, Noel Dybdal, Elissa Gazaille, Andrea Greiter-Wilke, Peter Hoffmann, Hai Huang, Carrie LaDuke, Kevin Norton, Jennifer B. Pierson, Isabelle Reeves, Brian Roche, Eric I. Rossman, Albert E. Schultze, Hai-Ming Tang, Todd Wisialowski, Simon Authier
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 121:107266
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::406a64798c781d5c1aa3597ac181212a
https://doi.org/10.1016/j.vascn.2023.107266
https://doi.org/10.1016/j.vascn.2023.107266
Autor:
Hugo M. Vargas, Eric I. Rossman, Todd A. Wisialowski, Jill Nichols, Michael K. Pugsley, Brian Roche, Gary A. Gintant, Andrea Greiter-Wilke, Robert B. Kleiman, Jean-Pierre Valentin, Derek J. Leishman
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 121:107265
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be76a6ce3a2e0c4c2deec09e77581719
https://doi.org/10.1016/j.vascn.2023.107265
https://doi.org/10.1016/j.vascn.2023.107265
Autor:
Eric I. Rossman, Todd A. Wisialowski, Hugo M. Vargas, Jean-Pierre Valentin, Michael G. Rolf, Brian M. Roche, Steve Riley, Michael K. Pugsley, Jill Nichols, Dingzhou Li, Derek J. Leishman, Robert B. Kleiman, Andrea Greiter-Wilke, Gary A. Gintant, Michael J. Engwall, Annie Delaunois, Simon Authier
Publikováno v:
Journal of Pharmacological and Toxicological Methods. :107270
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bce4cdaca3426f8bebb1500bde7339b
https://doi.org/10.1016/j.vascn.2023.107270
https://doi.org/10.1016/j.vascn.2023.107270
Autor:
Jean-Pierre Valentin, Peter Hoffmann, Catherine Ortemann-Renon, John Koerner, Jennifer Pierson, Gary Gintant, James Willard, Christine Garnett, Matthew Skinner, Hugo M Vargas, Todd Wisialowski, Michael K Pugsley
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 187(1)
The content of this article derives from a Health and Environmental Sciences Institute (HESI) consortium with a focus to improve cardiac safety during drug development. A detailed literature review was conducted to evaluate the concordance between no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1bab76e6e11698e6ce6d673f29f20d
https://pubmed.ncbi.nlm.nih.gov/35148401
https://pubmed.ncbi.nlm.nih.gov/35148401
Publikováno v:
European Journal of Pharmacology. 844:241-252
A series of amino-2-cyclohexyl ester derivatives were studied for their ion channel blocking and antiarrhythmic actions in the rat and a structure-activity analysis was conducted. The compounds are similar in chemical structure except for ionizable a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298155c861846a53a5ee41362571d065
https://doi.org/10.1016/j.ejphar.2018.12.025
https://doi.org/10.1016/j.ejphar.2018.12.025
Autor:
Franz J. Hock, Michael K. Pugsley
Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting wi
