Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Michael K Jensen"'
Autor:
Søren D Petersen, Lucas Levassor, Christine M Pedersen, Jan Madsen, Lea G Hansen, Jie Zhang, Ahmad K Haidar, Rasmus J N Frandsen, Jay D Keasling, Tilmann Weber, Nikolaus Sonnenschein, Michael K Jensen
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 3, p e1011929 (2024)
Synthetic biology dictates the data-driven engineering of biocatalysis, cellular functions, and organism behavior. Integral to synthetic biology is the aspiration to efficiently find, access, interoperate, and reuse high-quality data on genotype-phen
Externí odkaz:
https://doaj.org/article/c2a8272c0f8f4e8583e467f28cf7f764
Autor:
Hao Luo, Anne Sofie L Hansen, Lei Yang, Konstantin Schneider, Mette Kristensen, Ulla Christensen, Hanne B Christensen, Bin Du, Emre Özdemir, Adam M Feist, Jay D Keasling, Michael K Jensen, Markus J Herrgård, Bernhard O Palsson
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e2007050 (2019)
We present a selection design that couples S-adenosylmethionine-dependent methylation to growth. We demonstrate its use in improving the enzyme activities of not only N-type and O-type methyltransferases by 2-fold but also an acetyltransferase of ano
Externí odkaz:
https://doaj.org/article/8a014f6bc453477b97b3c4f4f1ca61cc
Autor:
Vasil D'Ambrosio, Lea G. Hansen, Jie Zhang, Emil D. Jensen, Dushica Arsovska, Marcos Laloux, Tadas Jakočiūnas, Pernille Hjort, Davide De Lucrezia, Serena Marletta, Jay D. Keasling, Michael K. Jensen
Publikováno v:
Synthetic and Systems Biotechnology, Vol 7, Iss 2, Pp 657-663 (2022)
The synthetic biology toolkit for baker's yeast, Saccharomyces cerevisiae, includes extensive genome engineering toolkits and parts repositories. However, with the increasing complexity of engineering tasks and versatile applications of this model eu
Externí odkaz:
https://doaj.org/article/350328b816f64150aa8b75abe0b35547
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Plants produce some of the most potent therapeutics and have been used for thousands of years to treat human diseases. Today, many medicinal natural products are still extracted from source plants at scale as their complexity precludes total synthesi
Externí odkaz:
https://doaj.org/article/055b6990f364454f9c678d756fdced61
Autor:
Helén Olsson, Paul Cachera, Hilde Coumou, Mads L. Jensen, Benjamín J. Sánchez, Tomas Strucko, Marcel van den Broek, Jean-Marc Daran, Michael K. Jensen, Nikolaus Sonnenschein, Michael Lisby, Uffe H. Mortensen
Biological functions are orchestrated by intricate networks of interacting genetic elements. Predicting the interaction landscape remains a challenge for systems biology and the identification of phenotypic maximas would be of great benefit to synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::993ef7c9b9d3674f40a99fd4cf6d6ef9
https://doi.org/10.1101/2022.07.19.500587
https://doi.org/10.1101/2022.07.19.500587
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2513
Here, in this chapter, we describe a detailed protocol for the method named Cas9-mediated protein evolution reaction or short CasPER. CasPER is based on the generation of large 300-600-bp mutagenized linear DNA fragments by error-prone PCR which are
Autor:
Amanda B, Abildgaard, Vasileios, Voutsinos, Søren D, Petersen, Fia B, Larsen, Caroline, Kampmeyer, Kristoffer E, Johansson, Amelie, Stein, Tommer, Ravid, Claes, Andréasson, Michael K, Jensen, Kresten, Lindorff-Larsen, Rasmus, Hartmann-Petersen
Publikováno v:
Cellular and molecular life sciences : CMLS. 80(1)
Protein quality control (PQC) degrons are short protein segments that target misfolded proteins for proteasomal degradation, and thus protect cells against the accumulation of potentially toxic non-native proteins. Studies have shown that PQC degrons
Autor:
Emil D. Jensen, Marcus Deichmann, Xin Ma, Rikke U. Vilandt, Giovanni Schiesaro, Marie B. Rojek, Bettina Lengger, Line Eliasson, Justin M. Vento, Deniz Durmusoglu, Sandie P. Hovmand, Ibrahim Al’Abri, Jie Zhang, Nathan Crook, Michael K. Jensen
Publikováno v:
Jensen, E D, Deichmann, M, Ma, X, Vilandt, R U, Schiesaro, G, Rojek, M B, Lengger, B, Eliasson, L, Vento, J M, Durmusoglu, D, Hovmand, S P, Al’Abri, I, Zhang, J, Crook, N & Jensen, M K 2022, ' Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts ', Nature Communications, vol. 13, 6201 . https://doi.org/10.1038/s41467-022-33961-y
G protein-coupled receptors (GPCRs) enable cells to sense environmental cues and are indispensable for coordinating vital processes including quorum sensing, proliferation, and sexual reproduction. GPCRs comprise the largest class of cell surface rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ad1b5af0e3584fa0756594b804defc
https://orbit.dtu.dk/en/publications/3355bb01-fa0d-44d9-b291-d393e87153ca
https://orbit.dtu.dk/en/publications/3355bb01-fa0d-44d9-b291-d393e87153ca
Publikováno v:
Methods in Molecular Biology ISBN: 9781071623985
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2040d268eca95abafacfccea84fa7c7
https://doi.org/10.1007/978-1-0716-2399-2_3
https://doi.org/10.1007/978-1-0716-2399-2_3
Autor:
Bettina Lengger, Emma E. Hoch-Schneider, Christina N. Jensen, Tadas Jakočiu̅nas, Anja A. Petersen, Thomas M. Frimurer, Emil D. Jensen, Michael K. Jensen
Publikováno v:
Lengger, B, Hoch-Schneider, E E, Jensen, C N, Jakočiū Nas, T, Petersen, A A, Frimurer, T M, Jensen, E D & Jensen, M K 2022, ' Serotonin G Protein-Coupled Receptor-Based Biosensing Modalities in Yeast ', ACS Sensors, vol. 7, no. 5, pp. 1323-1335 . https://doi.org/10.1021/acssensors.1c02061
Lengger, B, Hoch-Schneider, E E, Jensen, C N, Jakočiūnas, T, Petersen, A A, Frimurer, T M, Jensen, E D & Jensen, M K 2022, ' Serotonin G Protein-Coupled Receptor-Based Biosensing Modalities in Yeast ', ACS Sensors, vol. 7, no. 5, pp. 1323-1335 . https://doi.org/10.1021/acssensors.1c02061
Lengger, B, Hoch-Schneider, E E, Jensen, C N, Jakočiūnas, T, Petersen, A A, Frimurer, T M, Jensen, E D & Jensen, M K 2022, ' Serotonin G Protein-Coupled Receptor-Based Biosensing Modalities in Yeast ', ACS Sensors, vol. 7, no. 5, pp. 1323-1335 . https://doi.org/10.1021/acssensors.1c02061
Serotonin is a key neurotransmitter involved in numerous physiological processes and serves as an important precursor for manufacturing bioactive indoleamines and alkaloids used in the treatment of human pathologies. In humans, serotonin sensing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7893b9606c65bff895b986ced0287dda
https://curis.ku.dk/portal/da/publications/serotonin-g-proteincoupled-receptorbased-biosensing-modalities-in-yeast(9c957e48-10b8-4371-b2b3-c9b30e9201c3).html
https://curis.ku.dk/portal/da/publications/serotonin-g-proteincoupled-receptorbased-biosensing-modalities-in-yeast(9c957e48-10b8-4371-b2b3-c9b30e9201c3).html