Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Michael K E, Schäfer"'
Autor:
Sudena Wang, Marc-Philipp Weyer, Regina Hummel, Annett Wilken-Schmitz, Irmgard Tegeder, Michael K. E. Schäfer
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Progranulin (PGRN), which is produced in neurons and microglia, is a neurotrophic and anti-inflammatory glycoprotein. Human loss-of-function mutations cause frontotemporal dementia, and PGRN knockout (KO) mice are a model for dementia. In ad
Externí odkaz:
https://doaj.org/article/5cbe77842c2f488cadc8befd950c3dd6
Autor:
Katyayani Singh, Mohan Jayaram, Arpana Hanumantharaju, Tambet Tõnissoo, Toomas Jagomäe, Kaie Mikheim, Srirathi Muthuraman, Scott F. Gilbert, Mario Plaas, Michael K. E. Schäfer, Jürgen Innos, Kersti Lilleväli, Mari-Anne Philips, Eero Vasar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Deletions and malfunctions of the IgLON family of cell adhesion molecules are associated with anatomical, behavioral, and metabolic manifestations of neuropsychiatric disorders. We have previously shown that IgLON genes are expressed in sens
Externí odkaz:
https://doaj.org/article/d7ce1fd477ba4acf9a2adb3821533519
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1399 (2024)
Traumatic brain injury (TBI) and long bone fractures are a common injury pattern in polytrauma patients and modulate each other’s healing process. As only a limited number of studies have investigated both traumatic sites, we tested the hypothesis
Externí odkaz:
https://doaj.org/article/edd25dba69344802b711582fda1cde41
Autor:
Ralph Timaru-Kast, Shila P. Coronel-Castello, Tobias J. Krämer, André V. Hugonnet, Michael K. E. Schäfer, Anne Sebastiani, Serge C. Thal
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract After traumatic brain injury (TBI) cerebral inflammation with invasion of neutrophils and lymphocytes is a crucial factor in the process of secondary brain damage. In TBI the intrinsic renin-angiotensin system is an important mediator of cer
Externí odkaz:
https://doaj.org/article/2557f8d681d34b98b46b06fc3d1b1c2e
Autor:
Tobias J. Krämer, Florian Pickart, Bruno Pöttker, Christina Gölz, Axel Neulen, Tobias Pantel, Hermann Goetz, Katharina Ritter, Michael K. E. Schäfer, Serge C. Thal
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Traumatic brain injury (TBI) causes the release of danger-associated molecular patterns (DAMP) from damaged or dead cells, which contribute to secondary brain damage after TBI. Cell-free DNA (cfDNA) is a DAMP known to cause disruption of the
Externí odkaz:
https://doaj.org/article/86feabec15364ca8b03bfda43c74c694
Autor:
Regina Hummel, Erika Dorochow, Sonja Zander, Katharina Ritter, Lisa Hahnefeld, Robert Gurke, Irmgard Tegeder, Michael K. E. Schäfer
Publikováno v:
Cells, Vol 13, Iss 9, p 734 (2024)
The histone deacetylase inhibitor (HDACi) valproic acid (VPA) has neuroprotective and anti-inflammatory effects in experimental traumatic brain injury (TBI), which have been partially attributed to the epigenetic disinhibition of the transcription re
Externí odkaz:
https://doaj.org/article/53424d87a10a4d8da9740ff99c59f0c6
Autor:
Tobias J. Krämer, Per Hübener, Bruno Pöttker, Christina Gölz, Axel Neulen, Tobias Pantel, Hermann Goetz, Katharina Ritter, Michael K. E. Schäfer, Serge C. Thal
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Traumatic brain injury (TBI) involves primary mechanical damage and delayed secondary damage caused by vascular dysfunction and neuroinflammation. Intracellular components released into the parenchyma and systemic circulation, termed danger-
Externí odkaz:
https://doaj.org/article/0ce2da96cf5846cca14e90f9009e0a54
Publikováno v:
BMC Anesthesiology, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background The benzodiazepine midazolam is a γ-aminobutyric acid (GABA)-A receptor agonist frequently used for sedation or stress control in patients suffering from traumatic brain injury (TBI). However, experimental studies on benzodiazepi
Externí odkaz:
https://doaj.org/article/b92422003b67403ca2354345eba2c25c
Autor:
Yu Zhang, Xin Yang, Xinran Hou, Wen Zhou, Changlong Bi, Zhuanyi Yang, Sining Lu, Zijin Ding, Zhuofeng Ding, Yu Zou, Qulian Guo, Michael K. E. Schäfer, Changsheng Huang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Traumatic brain injury (TBI) induces a series of epigenetic changes in brain tissue, among which histone modifications are associated with the deterioration of TBI. In this study, we explored the role of histone H3 modifications in a weight-drop mode
Externí odkaz:
https://doaj.org/article/f40bee7c683d4a3ebd8ff39c1bd2e5fb
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Microglia are phagocytosis-competent CNS cells comprising a spectrum of subtypes with beneficial and/or detrimental functions in acute and chronic neurodegenerative disorders. The heterogeneity of microglia suggests differences in phagocytic activity
Externí odkaz:
https://doaj.org/article/138fbf2b689f42f6a23e708ce316e543