Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Michael K, Schuhmann"'
Autor:
Alexander M. Kollikowski, Mirko Pham, Alexander G. März, Jörn Feick, Marius L. Vogt, Yanyan Xiong, Marc Strinitz, Christoph Vollmuth, Fabian Essig, Hermann Neugebauer, Karl Georg Haeusler, Christian Hametner, Lena Zimmermann, Guido Stoll, Michael K. Schuhmann
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105095- (2024)
Summary: Background: Matrix metalloproteinases (MMPs) are implied in blood–brain barrier degradation and haemorrhagic transformation following ischaemic stroke, but their local relevance in the hyperacute disease phase is unknown. We aimed to exami
Externí odkaz:
https://doaj.org/article/6cbc00f3ba454381a890f3ccf41b2636
Autor:
Lorenzo Barba, Christoph Vollmuth, Samir Abu-Rumeileh, Steffen Halbgebauer, Patrick Oeckl, Petra Steinacker, Alexander M. Kollikowski, Cara Schultz, Judith Wolf, Mirko Pham, Michael K. Schuhmann, Peter U. Heuschmann, Karl Georg Haeusler, Guido Stoll, Hermann Neugebauer, Markus Otto
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract We aimed to assess the prognostic value of serum β-synuclein (β-syn), neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in patients with moderate-to-severe acute ischemic stroke. We measured β-syn, GFAP and NfL in
Externí odkaz:
https://doaj.org/article/e4b568f07c824155bc3dfb236de0636a
Autor:
Andreas Starke, Alexander M. Kollikowski, Vivian Vogt, Guido Stoll, Bernhard Nieswandt, Mirko Pham, David Stegner, Michael K. Schuhmann
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2191 (2024)
Background: Severe acute ischemic stroke (AIS) is mainly caused by thromboembolism originating from symptomatic carotid artery (ICA) stenosis or in the heart due to atrial fibrillation. Glycoprotein VI (GPVI), a principal platelet receptor, facilitat
Externí odkaz:
https://doaj.org/article/f668caeb58f740a484fde12cd765f6f1
Autor:
Maximilian Bellut, Michael Bieber, Peter Kraft, Alexander N. R. Weber, Guido Stoll, Michael K. Schuhmann
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-10 (2023)
Abstract Background Ischemic stroke immediately evokes a strong neuro-inflammatory response within the vascular compartment, which contributes to primary infarct development under vessel occlusion as well as further infarct growth despite recanalizat
Externí odkaz:
https://doaj.org/article/b07d3dec5ac44a9a93d01fbfd489fe2a
Autor:
Mert Seyhan, Kathrin Ungethüm, Michael K. Schuhmann, Daniel Mackenrodt, Viktoria Rücker, Felipe A. Montellano, Silke Wiedmann, Dominik Rath, Tobias Geisler, Bernhard Nieswandt, Peter Kraft, Christoph Kleinschnitz, Peter U. Heuschmann
Publikováno v:
Platelets, Vol 33, Iss 5, Pp 772-780 (2022)
Patients with ischemic stroke (IS) are at increased risk of mortality and recurrent cerebro- or cardiovascular events. Determining prognosis after IS remains challenging but blood-based biomarkers might provide additional prognostic information. As p
Externí odkaz:
https://doaj.org/article/957e13cb418b4b5da081382e82807652
Autor:
Christina David, Tobias Ruck, Leoni Rolfes, Stine Mencl, Peter Kraft, Michael K. Schuhmann, Christina B. Schroeter, Robin Jansen, Friederike Langhauser, Anne K. Mausberg, Anke C. Fender, Sven G. Meuth, Christoph Kleinschnitz
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 12 (2023)
Background Typically defined as a thromboinflammatory disease, ischemic stroke features early and delayed inflammatory responses, which determine the extent of ischemia‐related brain damage. T and natural killer cells have been implicated in neuron
Externí odkaz:
https://doaj.org/article/47877b69926b4bd58690f27262adb83a
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-10 (2021)
Abstract In ischemic stroke (IS) impairment of the blood–brain barrier (BBB) has an important role in the secondary deterioration of neurological function. BBB disruption is associated with ischemia-induced inflammation, brain edema formation, and
Externí odkaz:
https://doaj.org/article/61145514835b4f32a498b051fb0d0c11
Autor:
Vanessa Göb, Maximilian G. Voll, Lena Zimmermann, Katherina Hemmen, Guido Stoll, Bernhard Nieswandt, Michael K. Schuhmann, Katrin G. Heinze, David Stegner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Ischemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, successful recanalization of occluded vessels is the primary therapeutic aim, but even if it is achieved, not all patients benefit. Alth
Externí odkaz:
https://doaj.org/article/9e1757261a4d4ba1a3a35180f427cda9
Autor:
Michael K. Schuhmann, Michael Bieber, Maximilian Franke, Alexander M. Kollikowski, David Stegner, Katrin G. Heinze, Bernhard Nieswandt, Mirko Pham, Guido Stoll
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-9 (2021)
Abstract Background In acute ischemic stroke, cessation of blood flow causes immediate tissue necrosis within the center of the ischemic brain region accompanied by functional failure in the surrounding brain tissue designated the penumbra. The penum
Externí odkaz:
https://doaj.org/article/841feb61251540548bf969199a467fbc
Autor:
Axel Haarmann, Christoph Vollmuth, Alexander M. Kollikowski, Peter U. Heuschmann, Mirko Pham, Guido Stoll, Hermann Neugebauer, Michael K. Schuhmann
Publikováno v:
Cells, Vol 12, Iss 2, p 288 (2023)
Now that mechanical thrombectomy has substantially improved outcomes after large-vessel occlusion stroke in up to every second patient, futile reperfusion wherein successful recanalization is not followed by a favorable outcome is moving into focus.
Externí odkaz:
https://doaj.org/article/7e54e058b2fd4d8a904915e45c4d6dc7