Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Michael K, Axthelm"'
Autor:
Helen L Wu, Whitney C Weber, Courtney M Waytashek, Carla D Boyle, Jason S Reed, Katherine B Bateman, Hannah K Fisher, Yan Chen, Kimberly Armantrout, Tonya Swanson, Christine Shriver-Munsch, Mina Northrup, Miranda Fischer, Sreya Biswas, John Templon, Angela Panoskaltsis-Mortari, Benjamin J Burwitz, Amanda L Johnson, Lois Colgin, Anne D Lewis, Jeremy V Smedley, Michael K Axthelm, Rebecca Skalsky, Gabrielle Meyers, Richard T Maziarz, Erik Mittra, Melissa Berg, Jeffrey J Stanton, Jonah B Sacha
Publikováno v:
PLoS Pathogens, Vol 20, Iss 11, p e1012644 (2024)
Immunocompromised individuals are at risk for developing lymphocryptovirus-associated lymphoproliferative diseases, such as Epstein Barr virus (EBV)-associated B cell lymphomas and post-transplant lymphoproliferative disorder (PTLD). We previously re
Externí odkaz:
https://doaj.org/article/e9b7c4d3cacf41f4b7d8c3b2d116c58e
Autor:
Gabriela M. Escalante, Ivana G. Reidel, Lorraine Z. Mutsvunguma, Simeon Cua, Brenda A. Tello, Esther Rodriguez, Mafalda A. Farelo, Cloe Zimmerman, Murali Muniraju, He Li, Aparna N. Govindan, Michael K. Axthelm, Scott W. Wong, Javier Gordon Ogembo
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionEpstein-Barr virus (EBV) is an oncogenic human herpesvirus associated with ~350,000 cases of lymphoid and epithelial malignancies every year, and is etiologically linked to infectious mononucleosis and multiple sclerosis. Despite four dec
Externí odkaz:
https://doaj.org/article/8be24fa2fe95452194f5a54a9cd0960d
Autor:
Benjamin Varco-Merth, Morgan Chaunzwa, Derick M Duell, Alejandra Marenco, William Goodwin, Rachel Dannay, Michael Nekorchuk, Danica Shao, Kathleen Busman-Sahay, Christine M Fennessey, Lorna Silipino, Michael Hull, William J Bosche, Randy Fast, Kelli Oswald, Rebecca Shoemaker, Rachele Bochart, Rhonda MacAllister, Caralyn S Labriola, Jeremy V Smedley, Michael K Axthelm, Miles P Davenport, Paul T Edlefsen, Jacob D Estes, Brandon F Keele, Jeffrey D Lifson, Sharon R Lewin, Louis J Picker, Afam A Okoye
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012496 (2024)
Persistence of the rebound-competent viral reservoir (RCVR) within the CD4+ T cell compartment of people living with HIV remains a major barrier to HIV cure. Here, we determined the effects of the pan-lymphocyte-depleting monoclonal antibody (mAb) al
Externí odkaz:
https://doaj.org/article/98aa0bf5a0db40c1870449c56d1dca1f
Autor:
Whitney C Weber, Caralyn S Labriola, Craig N Kreklywich, Karina Ray, Nicole N Haese, Takeshi F Andoh, Michael Denton, Samuel Medica, Magdalene M Streblow, Patricia P Smith, Nobuyo Mizuno, Nina Frias, Miranda B Fisher, Aaron M Barber-Axthelm, Kimberly Chun, Samantha Uttke, Danika Whitcomb, Victor DeFilippis, Shauna Rakshe, Suzanne S Fei, Michael K Axthelm, Jeremy V Smedley, Daniel N Streblow
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011742 (2023)
Mayaro virus (MAYV) is a mosquito-transmitted alphavirus that causes debilitating and persistent arthritogenic disease. While MAYV was previously reported to infect non-human primates (NHP), characterization of MAYV pathogenesis is currently lacking.
Externí odkaz:
https://doaj.org/article/9deed2140f2e40a9aabdd1d8e7593a3d
Autor:
Rachele M Bochart, Kathleen Busman-Sahay, Stephen Bondoc, David W Morrow, Alexandra M Ortiz, Christine M Fennessey, Miranda B Fischer, Oriene Shiel, Tonya Swanson, Christine M Shriver-Munsch, Hugh B Crank, Kimberly M Armantrout, Aaron M Barber-Axthelm, Charlotte Langner, Cassandra R Moats, Caralyn S Labriola, Rhonda MacAllister, Michael K Axthelm, Jason M Brenchley, Brandon F Keele, Jacob D Estes, Scott G Hansen, Jeremy V Smedley
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011343 (2023)
[This corrects the article DOI: 10.1371/journal.ppat.1009565.].
Externí odkaz:
https://doaj.org/article/642da0372b874e13b89429f1a824dff1
Autor:
Aparna N. Govindan, Kristin S. Fitzpatrick, Minsha Manoharan, Ian Tagge, Steven G. Kohama, Betsy Ferguson, Samuel M. Peterson, Grayson S. Wong, William D. Rooney, Byung Park, Michael K. Axthelm, Dennis N. Bourdette, Larry S. Sherman, Scott W. Wong
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 2, Pp 456-470 (2021)
Abstract Objective To determine whether animals with Japanese macaque encephalomyelitis (JME), a spontaneous demyelinating disease similar to multiple sclerosis (MS), harbor myelin‐specific T cells in their central nervous system (CNS) and peripher
Externí odkaz:
https://doaj.org/article/e3983dd963594c35b1d381ed7a651083
Autor:
Benjamin D. Varco-Merth, William Brantley, Alejandra Marenco, Derick D. Duell, Devin N. Fachko, Brian Richardson, Kathleen Busman-Sahay, Danica Shao, Walter Flores, Kathleen Engelman, Yoshinori Fukazawa, Scott W. Wong, Rebecca L. Skalsky, Jeremy Smedley, Michael K. Axthelm, Jeffrey D. Lifson, Jacob D. Estes, Paul T. Edlefsen, Louis J. Picker, Cheryl M.A. Cameron, Timothy J. Henrich, Afam A. Okoye
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Proliferation of latently infected CD4+ T cells with replication-competent proviruses is an important mechanism contributing to HIV persistence during antiretroviral therapy (ART). One approach to targeting this latent cell expansion is to inhibit mT
Externí odkaz:
https://doaj.org/article/0626fdc3092c4cc489640700d2cf76b5
Autor:
Mariya B. Shapiro, Tracy Cheever, Delphine C. Malherbe, Shilpi Pandey, Jason Reed, Eun Sung Yang, Keyun Wang, Amarendra Pegu, Xuejun Chen, Don Siess, David Burke, Heidi Henderson, Rebecca Lewinsohn, Miranda Fischer, Jeffrey J. Stanton, Michael K. Axthelm, Christoph Kahl, Byung Park, Anne D. Lewis, Jonah B. Sacha, John R. Mascola, Ann J. Hessell, Nancy L. Haigwood
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Broadly neutralizing antibodies (bNAbs) are being evaluated for HIV post-exposure prophylaxis (PEP) in the setting of vertical transmission. Here, using a macaque model of perinatal SHIV infection, the authors show that PEP for infant macaques within
Externí odkaz:
https://doaj.org/article/96930173c51d4c149db6d9fcbe66090f
Autor:
Cassandra Moats, Kimberly Cook, Kimberly Armantrout, Hugh Crank, Samantha Uttke, Kelly Maher, Rachele M. Bochart, George Lawrence, Michael K. Axthelm, Jeremy V. Smedley
Publikováno v:
PLoS ONE, Vol 17, Iss 4 (2022)
Surgical antimicrobial prophylaxis is indicated when performing contaminated surgeries, when specific surgical implants are placed, and for prolonged surgical procedures. Unnecessary prophylactic antibiotics are often utilized for macaque surgeries,
Externí odkaz:
https://doaj.org/article/37b00141267b4db9bd86f3d3a1066686
Autor:
Fredrik Barrenäs, Scott G Hansen, Lynn Law, Connor Driscoll, Richard R Green, Elise Smith, Jean Chang, Inah Golez, Taryn Urion, Xinxia Peng, Leanne Whitmore, Daniel Newhouse, Colette M Hughes, David Morrow, Kurt T Randall, Andrea N Selseth, Julia C Ford, Roxanne M Gilbride, Bryan E Randall, Emily Ainslie, Kelli Oswald, Rebecca Shoemaker, Randy Fast, William J Bosche, Michael K Axthelm, Yoshinori Fukazawa, George N Pavlakis, Barbara K Felber, Slim Fourati, Rafick-Pierre Sekaly, Jeffrey D Lifson, Jan Komorowski, Ewelina Kosmider, Danica Shao, Wenjun Song, Paul T Edlefsen, Louis J Picker, Michael Gale
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009278 (2021)
Simian immunodeficiency virus (SIV) challenge of rhesus macaques (RMs) vaccinated with strain 68-1 Rhesus Cytomegalovirus (RhCMV) vectors expressing SIV proteins (RhCMV/SIV) results in a binary outcome: stringent control and subsequent clearance of h
Externí odkaz:
https://doaj.org/article/cd57c9263ff449bb8bd672c756c1208a