Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Michael K, Ahlijanian"'
Autor:
Samuel S. Shin, Vanessa M. Mazandi, Andrea L. C. Schneider, Sarah Morton, Jonathan P. Starr, M. Katie Weeks, Nicholas J. Widmann, David H. Jang, Shih-Han Kao, Michael K. Ahlijanian, Todd J. Kilbaugh
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1807 (2023)
Traumatic brain injury (TBI) results in the generation of tau. As hyperphosphorylated tau (p-tau) is one of the major consequences of TBI, targeting p-tau in TBI may lead to the development of new therapy. Twenty-five pigs underwent a controlled cort
Externí odkaz:
https://doaj.org/article/f4d54294249a4783acbd41a60ec0601f
Autor:
Kilbaugh, Samuel S. Shin, Vanessa M. Mazandi, Andrea L. C. Schneider, Sarah Morton, Jonathan P. Starr, M. Katie Weeks, Nicholas J. Widmann, David H. Jang, Shih-Han Kao, Michael K. Ahlijanian, Todd J.
Publikováno v:
Biomedicines; Volume 11; Issue 7; Pages: 1807
Traumatic brain injury (TBI) results in the generation of tau. As hyperphosphorylated tau (p-tau) is one of the major consequences of TBI, targeting p-tau in TBI may lead to the development of new therapy. Twenty-five pigs underwent a controlled cort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::fd999d7bc8c3c1b4c9fa44207362f3c2
Autor:
Kelly Foster, Matteo Manca, Kim McClure, Pyry Koivula, John Q. Trojanowski, Daniel Havas, Sarah Chancellor, Lee Goldstein, Kurt R. Brunden, Allison Kraus, Michael K. Ahlijanian
Publikováno v:
Alzheimer's & Dementia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::670a62c51b33a8206f666c5384627832
https://doi.org/10.1002/alz.13028
https://doi.org/10.1002/alz.13028
Autor:
John E. Macor, Yunhui Zhang, James E. Grace, Lorin A. Thompson, Jeremy H. Toyn, Lawrence R. Marcin, Subramaniam Krishnananthan, Jianliang Shi, Dmitry Zuev, Daniel Smith, Jianqing Li, Yong-Jin Wu, Jason M. Guernon, Xiaoliang Zhuo, Tatyana Zvyaga, Xu Li, Arvind Mathur, John Morrison, Jere E. Meredith, Charles F. Albright, S. Roy Kimura, Mendi A. Higgins, Kimberley A. Lentz, Richard E. Olson, Rex Denton, Kenneth M. Boy, Catherine R. Burton, Ashok K. Trehan, Michael K. Ahlijanian
Publikováno v:
ACS Medicinal Chemistry Letters
A triazine hit identified from a screen of the BMS compound collection was optimized for potency, in vivo activity, and off-target profile to produce the bicyclic pyrimidine γ-secretase modulator BMS-932481. The compound showed robust reductions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed62d494eee5e78e1c6f0f7838951135
http://europepmc.org/articles/PMC6421538
http://europepmc.org/articles/PMC6421538
Publikováno v:
Frontiers in Psychiatry, Vol 5 (2014)
Schizophrenia patients exhibit a decreased ability to detect change in their auditory environment as measured by auditory event related potentials such as mismatch negativity. This deficit has been linked to abnormal NMDA neurotransmission since, amo
Externí odkaz:
https://doaj.org/article/9b595b2dab26401491a20670ca79ef62
Autor:
Jeremy H. Toyn, Lorin A. Thompson, Kimberley A. Lentz, Jere E. Meredith, Catherine R. Burton, Sethu Sankaranararyanan, Valerie Guss, Tracey Hall, Lawrence G. Iben, Carol M. Krause, Rudy Krause, Xu-Alan Lin, Maria Pierdomenico, Craig Polson, Alan S. Robertson, R. Rex Denton, James E. Grace, John Morrison, Joseph Raybon, Xiaoliang Zhuo, Kimberly Snow, Ramesh Padmanabha, Michele Agler, Kim Esposito, David Harden, Margaret Prack, Sam Varma, Victoria Wong, Yingjie Zhu, Tatyana Zvyaga, Samuel Gerritz, Lawrence R. Marcin, Mendi A. Higgins, Jianliang Shi, Cong Wei, Joseph L. Cantone, Dieter M. Drexler, John E. Macor, Richard E. Olson, Michael K. Ahlijanian, Charles F. Albright
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2014 (2014)
Alzheimer’s disease is the most prevalent cause of dementia and is associated with accumulation of amyloid-β peptide (Aβ), particularly the 42-amino acid Aβ1-42, in the brain. Aβ1-42 levels can be decreased by γ-secretase modulators (GSM), whi
Externí odkaz:
https://doaj.org/article/1dce320132d4411583a19dcbfe2b54ae
Autor:
Aitor Martinez, Franziska Guenther, Benedikt M. Kessler, Katherine S. England, Elena Marcassa, Malte Gersch, Simon J. Davis, Alejandro Murad, Katherine J. Kayser-Bricker, Frederic Lamoliatte, Andreas Kallinos, Jane Jardine, Sylvie Urbé, Stephanos Ioannidis, Akshada Gajbhiye, Francesco G. Barone, Mariacarmela Giurrandino, Hannah C. Scott, Christopher J. Burke, Katy McCarron, David Komander, Emma J. Murphy, Alexandre J. Buckmelter, Matthias Trost, Michael K. Ahlijanian, Adan Pinto-Fernandez, Emma V Rusilowicz-Jones, Heather Mortiboys, Michael J. Clague
Publikováno v:
LIFE SCIENCE ALLIANCE
Life Science Alliance
Life Science Alliance
A new inhibitor of the deubiquitylase USP30, an actionable target relevant to Parkinson’s Disease, is introduced and characterised for parameters related to mitophagy.
The mitochondrial deubiquitylase USP30 negatively regulates the selective a
The mitochondrial deubiquitylase USP30 negatively regulates the selective a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb623ed1d21051d2610b1c0e5b7d95ea
http://livrepository.liverpool.ac.uk/3093573/1/LSA-2020-00768-TRR_Merged_PDF.pdf
http://livrepository.liverpool.ac.uk/3093573/1/LSA-2020-00768-TRR_Merged_PDF.pdf
Autor:
Adan Pinto-Fernandez, Heather Mortiboys, Christopher J. Burke, Andreas Kallinos, Simon J. Davis, Katherine J. Kayser-Bricker, Akshada Gajbhiye, Jane Jardine, Stephanos Ioannidis, David Komander, Michael J. Clague, Malte Gersch, Hannah C. Scott, Katy McCarron, Francesco G. Barone, Sylvie Urbé, Aitor Martinez, Alejandro Murad, Emma V Rusilowicz-Jones, Mariacarmela Giurrandino, Matthias Trost, Benedikt M. Kessler, Alexandre J. Buckmelter, Michael K. Ahlijanian, Emma J. Murphy, Franziska Guenther, Elena Marcassa, Frederic Lamoliatte, Katherine S. England
The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of damaged mitochondria. It has been proposed as an actionable target to alleviate the loss of function of the mitophagy pathway governed by the Parkinson’s Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c825509ce20a0d3a235b0e7ffe38de
https://doi.org/10.1101/2020.04.16.044206
https://doi.org/10.1101/2020.04.16.044206
Autor:
Michael Grundman, Gerry Kolaitis, Bechtold Clifford M, Giridhar S. Tirucherai, Irfan Qureshi, Michael K. Ahlijanian
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Introduction Extracellular tau is hypothesized to mediate the onset and progression of tauopathies, including Alzheimer's disease, progressive supranuclear palsy, and a subset of frontotemporal lobar degenerations. A putative strategy for treating th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7720cfc11cb2904a7a42932f9bfcc1d3
https://doi.org/10.1016/j.trci.2018.10.007
https://doi.org/10.1016/j.trci.2018.10.007
Autor:
Adrienne A. Tymiak, Richard Y.-C. Huang, Roxana E. Iacob, Guodong Chen, Li Tao, Ling Yang, Sethu Sankaranarayanan, Michael K. Ahlijanian
Publikováno v:
Journal of the American Society for Mass Spectrometry. 29:174-182
Fibrillization of the microtubule-associated protein tau has been recognized as one of the signature pathologies of the nervous system in Alzheimer's disease, progressive supranuclear palsy, and other tauopathies. The conformational transition of tau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13cec7f1eed7f934a2e8131f14ca0c08
https://doi.org/10.1007/s13361-017-1815-8
https://doi.org/10.1007/s13361-017-1815-8