Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Michael Junkin"'
Autor:
Brooke Schuster, Michael Junkin, Sara Saheb Kashaf, Isabel Romero-Calvo, Kori Kirby, Jonathan Matthews, Christopher R. Weber, Andrey Rzhetsky, Kevin P. White, Savaş Tay
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The use of organoids in personalized medicine is promising but high throughput platforms are needed. Here the authors develop an automated, high-throughput, microfluidic 3D organoid culture system that allows combinatorial and dynamic drug treatments
Externí odkaz:
https://doaj.org/article/438a4d38d7d84d97b586b8ca0dd0e923
Autor:
Michael Junkin, Alicia J. Kaestli, Zhang Cheng, Christian Jordi, Cem Albayrak, Alexander Hoffmann, Savaş Tay
Publikováno v:
Cell Reports, Vol 15, Iss 2, Pp 411-422 (2016)
Cells receive time-varying signals from the environment and generate functional responses by secreting their own signaling molecules. Characterizing dynamic input-output relationships in single cells is crucial for understanding and modeling cellular
Externí odkaz:
https://doaj.org/article/619ce72e58da408cb4e9ef3555df9139
Autor:
Jakub Pękalski, Pawel J Zuk, Marek Kochańczyk, Michael Junkin, Ryan Kellogg, Savaş Tay, Tomasz Lipniacki
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78887 (2013)
NF-κB is a key transcription factor that regulates innate immune response. Its activity is tightly controlled by numerous feedback loops, including two negative loops mediated by NF-κB inducible inhibitors, IκBα and A20, which assure oscillatory
Externí odkaz:
https://doaj.org/article/597678e9c22c44a48709d94dd603c206
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 12, p e1002847 (2012)
In this paper, we present a combined theoretical and experimental study of the propagation of calcium signals in multicellular structures composed of human endothelial cells. We consider multicellular structures composed of a single chain of cells as
Externí odkaz:
https://doaj.org/article/4c9372e9a88d4abd953c6f6d93fc189f
Autor:
Kevin P. White, Savaş Tay, Isabel Romero-Calvo, Brooke Schuster, Jonathan Matthews, Sara Saheb Kashaf, Kori Kirby, Michael Junkin, Christopher R. Weber, Andrey Rzhetsky
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Three-dimensional (3D) cell culture technologies, such as organoids, are physiologically relevant models for basic and clinical applications. Automated microfluidics offers advantages in high-throughput and precision analysis of cells but is not yet
Autor:
Andrew Wang, Ala Trusina, Minjun Son, Savaş Tay, Sara Saheb Kashaf, Thomas Holst-Hansen, Tino Frank, Michael Junkin
Publikováno v:
Science Advances, 8 (35)
Son, M, Frank, T, Holst-Hansen, T, Wang, A G, Junkin, M, Kashaf, S S, Trusina, A & Tay, S 2022, ' Spatiotemporal NF-kappa B dynamics encodes the position, amplitude, and duration of local immune inputs ', Science Advances, vol. 8, no. 35, 6240 . https://doi.org/10.1126/sciadv.abn6240
Son, M, Frank, T, Holst-Hansen, T, Wang, A G, Junkin, M, Kashaf, S S, Trusina, A & Tay, S 2022, ' Spatiotemporal NF-kappa B dynamics encodes the position, amplitude, and duration of local immune inputs ', Science Advances, vol. 8, no. 35, 6240 . https://doi.org/10.1126/sciadv.abn6240
Infected cells communicate through secreted signaling molecules like cytokines, which carry information about pathogens. How differences in cytokine secretion affect inflammatory signaling over space and how responding cells decode information from p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12cfd87b9731a2a6eed3396c5610c91
https://doi.org/10.1101/2021.11.30.470463
https://doi.org/10.1101/2021.11.30.470463
Autor:
Chuanyu Liu, Tao Wu, Fei Fan, Ya Liu, Liang Wu, Michael Junkin, Zhifeng Wang, Yeya Yu, Weimao Wang, Wenbo Wei, Yue Yuan, Mingyue Wang, Mengnan Cheng, Xiaoyu Wei, Jiangshan Xu, Quan Shi, Shiping Liu, Ao Chen, Ou Wang, Ming Ni, Wenwei Zhang, Zhouchun Shang, Yiwei Lai, Pengcheng Guo, Carl Ward, Giacomo Volpe, Lei Wang, Huan Zheng, Yang Liu, Brock A. Peters, Jody Beecher, Yongwei Zhang, Miguel A. Esteban, Yong Hou, Xun Xu, I-Jane Chen, Longqi Liu
Single-cell technologies are becoming increasingly widespread and have been revolutionizing our understanding of cell identity, state, diversity and function. However, current platforms can be slow to apply to large-scale studies and resource-limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10046d0c958e329d0e9e6bb1c865c68
Autor:
Alexander Hoffmann, Alicia J. Kaestli, Cem Albayrak, Michael Junkin, Savaş Tay, Christian Jordi, Zhang Cheng
Publikováno v:
Cell Reports
Cell Reports, 15 (2)
Cell Reports, Vol 15, Iss 2, Pp 411-422 (2016)
Cell Reports, 15 (2)
Cell Reports, Vol 15, Iss 2, Pp 411-422 (2016)
Summary Cells receive time-varying signals from the environment and generate functional responses by secreting their own signaling molecules. Characterizing dynamic input-output relationships in single cells is crucial for understanding and modeling
Publikováno v:
Biomaterials. 34:2049-2056
Calcium signaling in the diverse vascular structures is regulated by a wide range of mechanical and biochemical factors to maintain essential physiological functions of the vasculature. To properly transmit information, the intercellular calcium comm
Autor:
Michael Junkin, Pak Kin Wong
Publikováno v:
Biomaterials. 32:1848-1855
Cellular processes are regulated by various mechanical and physical factors in their local microenvironment such as geometric confinements, cell–substrate interactions, and cell–cell contact. Systematic elucidation of these regulatory mechanisms