Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Michael J. Zacuto"'
Advancing Scalable Chemistry toward Novel CELMoDs: Process Development for the Synthesis of CC-90009
Autor:
Michael J. Zacuto, Michael J. Williams, Weihong Zhang, Jianxin Han, Marie G. Beauchamps, Mohit Kothare, William Konnecke, Randi Smith, Gregg Feigelson
Publikováno v:
Organic Process Research & Development. 26:2739-2748
Autor:
Lucille A. Wells, Michael R. Gau, Michael B. Peddicord, Kirsten F. Bostwick, Marisa C. Kozlowski, Michael J. Zacuto
Publikováno v:
Organic Process Research & Development. 26:1803-1811
Autor:
Michael J. Zacuto, Abigail G. Doyle, Benjamin J. Shields, Stavros K. Kariofillis, Makeda A. Tekle-Smith
Publikováno v:
J Am Chem Soc
Methylation of organohalides represents a valuable transformation, but typically requires harsh reaction conditions or reagents. We report a radical approach for the methylation of (hetero)aryl chlorides using nickel/photoredox catalysis wherein trim
Publikováno v:
Organic Process Research & Development. 23:2080-2087
Sodium triacetoxyborohydride (STAB) is a common reducing agent with potency that degrades over time and is not uniformly assigned. A simple assay based on an aldehyde reduction has been developed t...
Autor:
Michael Williams, Benjamin J. Shields, Michael J. Zacuto, Abigail G. Doyle, Junyi Liu, Matthew K. Nielsen
Publikováno v:
Angewandte Chemie International Edition. 56:7191-7194
We report a redox-neutral formylation of aryl chlorides that proceeds through selective 2-functionalization of 1,3-dioxolane through nickel and photoredox catalysis. This scalable benchtop approach provides a distinct advantage over traditional reduc
Autor:
Michael J. Zacuto
Publikováno v:
The Journal of organic chemistry. 84(10)
A selective synthesis of acrylamides had been developed using the Doebner-Knoevenagel condensation. The reaction occurs under mild conditions at ambient temperatures, tolerates a wide array of functional groups, and affords the E-isomer with high sel
Autor:
John S. Edwards, Teresa Andreani, Michael Williams, Hongmei Li, Jongrock Kong, Peter R. Mullens, Brian C. Bishop, Ed Cleator, Adrian Goodyear, Michael J. Zacuto, Yan Jin, Mark McLaughlin
Publikováno v:
Organic Process Research & Development. 20:1075-1087
Two new routes to a pyrimidyl tetrazole intermediate are described. The first-generation route featured an iron-catalyzed cross-coupling between 4-butenylmagnesium bromide and a 4-chloropyrimidine derivative to afford an alkene-bearing pyrimidine int
Autor:
Feng Xu, Yoshinori Kohmura, Michael J. Zacuto, Jon Rosen, Jeremy P. Scott, Andrew D. Gibb, Mahbub Alam, David M. Tschaen
Publikováno v:
Organic Letters. 16:5422-5425
A practical synthesis of a highly functionalized tetrahydropyran DPP-4 inhibitor is described. The asymmetric synthesis relies on three back-to-back Ru-catalyzed reactions. A Ru-catalyzed dynamic kinetic resolution (DKR) reduction establishes two con
Publikováno v:
The Journal of Organic Chemistry. 79:8917-8925
A practical one-step method has been developed to prepare α-chloroketones from readily available, inexpensive phenylacetic acid derivatives. The method utilizes the unique reactivity of an intermediate Mg-enolate dianion, which displays selectivity