Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael J. Woolley"'
Publikováno v:
Biochemistry. 56:3877-3880
The second extracellular loop (ECL2) of the G protein-coupled receptor (GPCR) family is important for ligand interaction and drug discovery. ECL2 of the family B cardioprotective calcitonin gene-related peptide (CGRP) receptor is required for cell si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4c8fc9383cdd293a18952cc5c47cd3
https://doi.org/10.1021/acs.biochem.7b00077
https://doi.org/10.1021/acs.biochem.7b00077
Autor:
Michael J. Woolley, Alex C. Conner
Publikováno v:
Molecular and Cellular Endocrinology. 449:3-11
The extracellular loops (ECLs) of G protein-coupled receptors (GPCRs) can bind directly to docked orthosteric or allosteric ligands, they can contain transient contact points for ligand entry into the transmembrane (TM) bundle and they can regulate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35853cd559256b7dd75fd3fdcd8ccb09
https://doi.org/10.1016/j.mce.2016.11.023
https://doi.org/10.1016/j.mce.2016.11.023
Autor:
Juan Carlos Mobarec, Christopher A. Reynolds, Michael J. Woolley, John Simms, Alex C. Conner, David R. Poyner
The extracellular loop 2 (ECL2) region is the most conserved of the three ECL domains in family B G protein-coupled receptors (GPCRs) and has a fundamental role in ligand binding and activation across the receptor super-family. ECL2 is fundamental fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609a3b08b96c679c1e0365080ef49dd4
https://publications.aston.ac.uk/id/eprint/30885/1/Molecular_functions_of_ECL2_of_CGRP.pdf
https://publications.aston.ac.uk/id/eprint/30885/1/Molecular_functions_of_ECL2_of_CGRP.pdf
Autor:
Shreya Chand, Shilpi Mahajan, Burcu Hasdemir, Dimitris K. Grammatopoulos, Michael J. Woolley, Aditi Bhargava, Alma L. Burlingame, Juan A. Oses-Prieto
Publikováno v:
Molecular biology of the cell, vol 28, iss 18
Molecular Biology of the Cell
Molecular Biology of the Cell
A physical interaction is shown between CRF1R and CRF2R, two class B G protein–coupled receptors that mediate stress and immune responses. Trafficking of CRF2R but not CRF1R is actin dependent, and coexpression of the two receptors alters actin-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06283358155b591d54cb93eb5098c80
https://escholarship.org/uc/item/87j2w394
https://escholarship.org/uc/item/87j2w394
Publikováno v:
Biochemistry. 56(30)
The second extracellular loop (ECL2) of the G protein-coupled receptor (GPCR) family is important for ligand interaction and drug discovery. ECL2 of the family B cardioprotective calcitonin gene-related peptide (CGRP) receptor is required for cell si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30359f7a281791541f96c44556158c69
https://pubmed.ncbi.nlm.nih.gov/28691801
https://pubmed.ncbi.nlm.nih.gov/28691801
Background Calcitonin gene-related peptide (CGRP) is a neuropeptide that acts in the trigeminovascular system and is believed to play an important role in migraine. CGRP activates two receptors that are both present in the trigeminovascular system; t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90d43e878766131fcd415607e2a843b
https://europepmc.org/articles/PMC5494006/
https://europepmc.org/articles/PMC5494006/
Autor:
Alex C. Conner, Michael J. Woolley
Publikováno v:
Current Protein & Peptide Science. 14:358-374
CGRP and adrenomedullin [AM] are peptides that have a number of physiological effects, including vasodilation, through the activation of a shared GPCR, the family B calcitonin receptor-like receptor [CLR]. Specificity to each ligand is conferred thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d838e403d50344f19328e50a130551e3
https://doi.org/10.2174/13892037113149990053
https://doi.org/10.2174/13892037113149990053
Publikováno v:
Biochemical Society Transactions. 40:433-437
The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity-modifying protein 1). RAMP1 is need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdab855d2729d9c5f90e854417e6bd1a
https://doi.org/10.1042/bst20110726
https://doi.org/10.1042/bst20110726
Autor:
David R. Poyner, James Barwell, Meenakshi Pardamwar, Harriet A. Watkins, Augen A. Pioszak, James M.W.R. McElhinney, Debbie L. Hay, Michael L. Garelja, Michael J. Woolley, Alexander Lathbridge, Madhuri Chakravarthy, Joseph J. Gingell, Christopher A. Reynolds, Arran Constantine, Rekhati S. Abhayawardana, Paul W. R. Harris, Alex C. Conner, Tsz Ying Yuen, Margaret A. Brimble
Publikováno v:
The Journal of Biological Chemistry
Adrenomedullin (AM) is a peptide hormone with numerous effects in the vascular systems. AM signals through the AM1 and AM2 receptors formed by the obligate heterodimerization of a G protein-coupled receptor, the calcitonin receptor-like receptor (CLR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437db1e418f0764b7c0d3db861e1333b
https://pubmed.ncbi.nlm.nih.gov/27013657
https://pubmed.ncbi.nlm.nih.gov/27013657
Autor:
Kevin J. Smith, Michael J. Woolley, Bruck Taddese, David R. Poyner, James Barwell, Debbie L. Hay, Z. Gamze Karakullukcu, Christopher A. Reynolds, Alex C. Conner, Harriet A. Watkins
Publikováno v:
Journal of the Royal Society Interface
The calcitonin gene-related peptide (CGRP) receptor is a complex of a cal-citonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1. The role of the second extracellular loop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b525c19416987f5612a15a243b488d8
https://publications.aston.ac.uk/id/eprint/20096/1/Role_of_ECL2_in_CGRP_receptor_activation.pdf
https://publications.aston.ac.uk/id/eprint/20096/1/Role_of_ECL2_in_CGRP_receptor_activation.pdf