The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing.

Autor: Daniela Begolo, Isabel M Vincent, Federica Giordani, Ina Pöhner, Michael J Witty, Timothy G Rowan, Zakaria Bengaly, Kirsten Gillingwater, Yvonne Freund, Rebecca C Wade, Michael P Barrett, Christine Clayton

Publikováno v: PLoS Pathogens, Vol 14, Iss 9, p e1007315 (2018)

Kinetoplastid parasites-trypanosomes and leishmanias-infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies. Benzoxaborole-based compounds are very promising potential

Externí odkaz: https://doaj.org/article/e1674f3ac3f24f8baaf483e779b5f349

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs

Autor: Eva Rico, Andrew W. Pountain, Isabel M. Vincent, Michael J. Witty, Michael P. Barrett, Fernando Fernandez-Cortes, Ning Zhang, Mark C. Field, David Horn, Jonathan M. Wilkes, Justin J. J. van der Hooft, Yvonne Freund, Darren Y. Edwards, Daniel Paape, Liam J. Morrison, Rosemary Peter, Clément Regnault, Federica Giordani, Kevin D. Read

Publikováno v: PLoS Pathogens, Vol 16, Iss 11, p e1008932 (2020)
PLoS Pathogens
PLoS Pathogens, 16(11)
PLoS Pathogens 16 (2020) 11
Giordani, F, Paape, D, Vincent, I M, Pountain, A W, Fernandez-Cortes, F, Rico, E, Zhang, N, Morrison, L, Freund, Y, Witty, M J, Peter, R, Edwards, D, Wilkes, J, van der Hooft, J J J, Regnault, C, Read, K D, Horn, D, Field, M C & Barrett, M P 2020, ' Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs ', PLoS Pathogens, vol. 16, no. 11, e1008932 . https://doi.org/10.1371/journal.ppat.1008932

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a3504630182edfb682742da45095c8
https://doaj.org/article/a5d1aac4a0fd47b29679ea476bd015f8

Erratum for Brunschwig et al., 'UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria'

Autor: Tanya Paquet, David A. Fidock, Efrem Abay, Iñigo Angulo-Barturen, Kigbafori D. Silué, Diego Gonzàlez Cabrera, Mathew Njoroge, Leslie J. Street, Rintis Noviyanti, Karen L. White, Grennady Wirjanata, Cristina Donini, Michael J Witty, Nina Lawrence, Dalu Mancama, Lyn-Marie Birkholtz, Claire Le Manach, Sergio Wittlin, Ric N. Price, María Belén Jiménez-Díaz, Lubbe Wiesner, Jutta Marfurt, Didier Leroy, David Waterson, Peter Siegl, Christel Brunschwig, Paul V. Fish, Aloysius T. Nchinda, Manu Vanaerschot, Jacob A. McPhail, Mariëtte van der Watt, Dale Taylor, Susan A. Charman, Gregory S. Basarab, Carmen de Kock, Esperanza Herreros, John E. Burke, Suresh Solapure, Kennan C. Marsh, Francisco-Javier Gamo, Kelly Chibale, Theresa L. Coetzer, James Duffy, Rosemary Rochford, Janette Reader, Paolo Denti, Dennis A. Smith, Benjamin Blasco

Publikováno v: Antimicrobial Agents and Chemotherapy. 62

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65fbee621a580f76b6953115ab78b9e3
https://doi.org/10.1128/aac.01941-18

The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing

Autor: Timothy G. Rowan, Federica Giordani, Christine Clayton, Isabel M. Vincent, Zakaria Bengaly, Daniela Begolo, Michael P. Barrett, Yvonne Freund, Kirsten Gillingwater, Michael J. Witty

Kinetoplastid parasites - trypanosomes and leishmanias - infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies. Benzoxaborole-based compounds are very promising potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafadd72620ecdaf33fd64ec6fc701c7

Correction to The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

Autor: Paul Willis, Elena Sandoval, Carolyn Selenski, Michael J Witty, Maria Jesus Almela, Jaime de Mercado, Sonja Ghidelli-Disse, Jeremy N. Burrows, Simon J. F. Macdonald, Anne Rodríguez, Santiago Ferrer-Bazaga, Cristina de Cozar, Beatriz Hernández Díaz, Paul Bamborough, Sara Prats, Rubén M. Gómez, María Belén Jiménez Díaz, Maria Jose Lafuente-Monasterio, Iñigo Angulo-Barturen, Margarita Puente, David M. Wilson, Jose M. Coteron, Juan C. de la Rosa, Pablo Castañeda, María Luisa León, Francisco J. Gamo, Jose Ignacio Martin Hernando, John N. Haselden, María J. Chaparro, Sophie Huss, María T. Fraile, Lourdes Rueda, Félix Calderón, Nicholas Cammack, Maria Santos Martinez-Martinez, Gerard Drewes, J. Vidal, Benigno Crespo, Esther Fernández

Publikováno v: Journal of medicinal chemistry. 60(23)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca0175d454f38a34fcaa02c5eae30f5
https://pubmed.ncbi.nlm.nih.gov/28806082