Copper complexes with dissymmetrically substituted bis(thiosemicarbazone) ligands as a basis for PET radiopharmaceuticals: control of redox potential and lipophilicity

Autor: Katherine B. Holt, Philip J. Blower, Julia Baguña Torres, Michael J. Went, Oliver C. Brown

Publikováno v: Dalton Transactions. 46:14612-14630

Copper (II) bis(thiosemicarbazone) derivatives have been used extensively in positron emission tomography (PET) to image hypoxia and blood flow and to radiolabel cells for cell tracking. These applications depend on control of redox potentials and li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b80118d4ff9661377072c4c51e70168
https://doi.org/10.1039/c7dt02008b

Crystal structure of [butane-2,3-dione bis(4-methylthiosemicarbazonato)-κ4S,N1,N1′,S′](pyridine-κN)zinc(II)

Autor: Philip J. Blower, Derek A. Tocher, Michael J. Went, Oliver C. Brown

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 11, Pp 1349-1351 (2015)

The title compound was prepared by the reaction of [butane-2,3-dione bis­(4-methyl­thio­semicarbazonato)]zinc(II) with pyridine. The ZnII atom is five-coordinate in a pseudo-square-pyramidal geometry.
In the structure of the title complex, [Z

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5b5ebe55756401eb6529767290f1f8
https://doi.org/10.1107/s2056989015019234

The spectroscopic detection of drugs of abuse in fingerprints after development with powders and recovery with adhesive lifters

Autor: Michael J. Went, Matthew J. West

Publikováno v: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 71:1984-1988

The application of powders to fingerprints has long been established as an effective and reliable method\ud for developing latent fingerprints. Fingerprints developed in situ at a crime scene routinely undergo lifting\ud with specialist tapes and are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb1f24e1461ea894ba6992ef1018b44
https://doi.org/10.1016/j.saa.2008.07.024

Investigation into 64Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents

Autor: Paul McQuade, Katherine E. Martin, Michael J. Went, Michael J. Welch, Thomas C. Castle, Philip J. Blower, Jason S. Lewis

Publikováno v: Nuclear Medicine and Biology. 32:147-156

Background Cu-diacetyl-bis( N 4 -methylthiosemicarbazone) [Cu-ATSM], although excellent for oncology applications, may not be suitable for delineating cardiovascular or neurological hypoxia. For this reason, new Cu hypoxia positron emission tomograph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06c36912ce42c80aaebfa521ac16345
https://doi.org/10.1016/j.nucmedbio.2004.10.004

[(89)Zr]oxinate4 for long-term in vivo cell tracking by positron emission tomography

Autor: Putthiporn, Charoenphun, Levente K, Meszaros, Krisanat, Chuamsaamarkkee, Ehsan, Sharif-Paghaleh, James R, Ballinger, Trevor J, Ferris, Michael J, Went, Gregory E D, Mullen, Philip J, Blower

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging

Purpose 111In (typically as [111In]oxinate3) is a gold standard radiolabel for cell tracking in humans by scintigraphy. A long half-life positron-emitting radiolabel to serve the same purpose using positron emission tomography (PET) has long been sou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::065004fa8361bce67a7c65e30957e53e
https://pubmed.ncbi.nlm.nih.gov/25359636