Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Michael J. Torres"'
Autor:
Tuo Wei, Yehui Sun, Qiang Cheng, Sumanta Chatterjee, Zachary Traylor, Lindsay T. Johnson, Melissa L. Coquelin, Jialu Wang, Michael J. Torres, Xizhen Lian, Xu Wang, Yufen Xiao, Craig A. Hodges, Daniel J. Siegwart
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Approximately 10% of Cystic Fibrosis (CF) patients, particularly those with CF transmembrane conductance regulator (CFTR) gene nonsense mutations, lack effective treatments. The potential of gene correction therapy through delivery of the CR
Externí odkaz:
https://doaj.org/article/220903d538f7496e9c1e3362c609fff3
Autor:
Melissa Coquelin, Busola R. Alabi, Sei Sho, Michael J. Torres, Jennifer R. Peters-Hall, Jose Francisco Calva-Moreno, Ryan LaRanger, Jerry W. Shay, Philip Thomas
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 315:L313-L327
While primary cystic fibrosis (CF) and non-CF human bronchial epithelial basal cells (HBECs) accurately represent in vivo phenotypes, one barrier to their wider use has been a limited ability to clone and expand cells in sufficient numbers to produce
Autor:
Daniel J. Siegwart, Aderonke Sofoluwe, Michael J. Torres, Jeffrey M. Beekman, Liudmila Cebotaru, Marne C. Hagemeijer, Lisa J. Strug
Publikováno v:
Journal of Cystic Fibrosis. 17:S46-S51
Translational research efforts in cystic fibrosis (CF) aim to develop therapies for all subjects with CF. To reach this goal new therapies need to be developed that target multiple aspects of the disease. To enable individuals to benefit maximally fr
Autor:
Michael J. Torres, Clayton R. Hunt, Michael A. White, Rakesh Kumar, Etienne Formstecher, Lawrence G. Lum, Charles Yeaman, Raj K. Pandita, Tej K. Pandita, Yingming Zhao, Nobuo Horikoshi, Aubhishek Zaman, Ozlem Kulak, Kalpana Mujoo
Publikováno v:
Molecular and Cellular Biology. 35:3633-3645
The exocyst is a heterooctomeric complex well appreciated for its role in the dynamic assembly of specialized membrane domains. Accumulating evidence indicates that this macromolecular machine also serves as a physical platform that coordinates regul
Autor:
Michael J. Torres, Saurabh Mendiratta, Brian O. Bodemann, Michael A. White, Ugur Eskiocak, Rosalyn Ram
Publikováno v:
Molecular and Cellular Biology. 34:2350-2358
The RASSF1A gene is one of the most frequently inactivated genes in over 30 different types of cancers (H. Donninger, M. D. Vos, and G. J. Clark, J. Cell Sci. 120:3163-3172, 2007, http://dx.doi.org/10.1242/jcs.010389). Despite the prevalence of RASSF
Autor:
Tsutomu, Shimura, Melvenia M, Martin, Michael J, Torres, Cory, Gu, Janice M, Pluth, Maria A, DeBernardi, Maria A, DiBernardi, Jeffrey S, McDonald, Mirit I, Aladjem
Publikováno v:
Journal of Molecular Biology. 367:665-680
Summary Cells that suffer substantial inhibition of DNA replication halt their cell cycle via a checkpoint response mediated by the PI3 kinases ATM and ATR. It is unclear how cells cope with milder replication insults, which are under the threshold f
Autor:
Rolf A. Brekken, Rosalyn Ram, Yi Hung Ou, Michael J. Torres, Seng Lai Tan, Ryan Wurz, Tzuling Cheng, Christina Lynn Roland, Tony Polverino, Andrew Tasker, Michael A. White, Etienne Formstecher
Publikováno v:
Molecular cell. 41(4)
The innate immune-signaling kinase, TBK1, couples pathogen surveillance to induction of host defense mechanisms. Pathological activation of TBK1 in cancer can overcome programmed cell death cues, enabling cells to survive oncogenic stress. The mechan