Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael J. Surace"'
Autor:
Debolina D. Biswas, Rebecca K. Martin, LaShardai N. Brown, Karli Mockenhaupt, Angela S. Gupta, Michael J. Surace, Anuj Tharakan, Jessie W. Yester, Reetika Bhardwaj, Daniel H. Conrad, Tomasz Kordula
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background Immune activation, neuroinflammation, and cell death are the hallmarks of multiple sclerosis (MS), which is an autoimmune demyelinating disease of the central nervous system (CNS). It is well-documented that the cellular inhibitor
Externí odkaz:
https://doaj.org/article/6c833ed3cee3440db1a9c38026d20d4d
Autor:
Ignacio I Wistuba, Michael T Tetzlaff, Carlo B Bifulco, Katharina von Loga, Sacha Gnjatic, Scott J Rodig, Keith E Steele, Marlon C Rebelatto, Ana Lako, Guray Akturk, Michael Angelo, Shirley Greenbaum, Noah F Greenwald, Cyrus V Hedvat, Travis J Hollmann, Jonathan Juco, Jaime Rodriguez-Canales, Kurt A Schalper, Edward C Stack, Cláudia S Ferreira, Konstanty Korski, Emanuel Schenck, Michael J Surace
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20153 (2011)
NADPH oxidase is implicated in neurotoxic microglial activation and the progressive nature of Alzheimer's Disease (AD). Here, we test the ability of two NADPH oxidase inhibitors, apocynin and dextromethorphan (DM), to reduce learning deficits and neu
Externí odkaz:
https://doaj.org/article/907bbaba92f7409bacc933a843ec67ac
Autor:
Tomasz Kordula, Lashardai N. Brown, Ulrich Siebenlist, Debolina D. Biswas, Michael R. Waters, Angela S. Gupta, Michael J. Surace, Constantinos Floros
Publikováno v:
Glia
In response to brain injury or infections, astrocytes become reactive, undergo striking morphological and functional changes, and secrete and respond to a spectrum of inflammatory mediators. We asked whether reactive astrocytes also display adaptive
Autor:
Shannon Levesque, Prasada Rao S. Kodavanti, Michael J. Surace, Urmila P. Kodavanti, Christen L. Mumaw, Michelle L. Block, Joyce E. Royland
Accumulating evidence suggests a deleterious role for urban air pollution in central nervous system (CNS) diseases and neurodevelopmental disorders. Microglia, the resident innate immune cells and sentinels in the brain, are a common source of neuroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc34175fe99a5342b2ad7e9996d1569
https://europepmc.org/articles/PMC6757344/
https://europepmc.org/articles/PMC6757344/
Autor:
Michael J. Surace, Shannon Levesque, Michelle L. Block, Krisztian Stadler, Thomas Taetzsch, Jo Anne Johnson, Urmila P. Kodavanti, Melinda E. Lull, Prasada Rao S. Kodavanti, Alison F. Wagner, Laura Duke
Publikováno v:
Environmental Health Perspectives
Background: Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood. Objectives: Here, we sought to address the brain-region–specific effects of diesel exhaust (DE) and key cellular mechanisms
Autor:
Jose M. Eltit, Debolina D. Biswas, Lauren Bryan, Jessie W. Yester, Bartosz Mierzenski, Angela S. Gupta, Michael J. Surace, Michael R. Waters, Sheldon Milstien, Tomasz Kordula, Reetika Bhardwaj, Sarah Spiegel
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(12)
The neuroinflammation associated with multiple sclerosis involves activation of astrocytes that secrete and respond to inflammatory mediators such as IL-1. IL-1 stimulates expression of many chemokines, including C-C motif ligand (CCL) 5, that recrui
Autor:
Zhenqiang Yao, Reetika Bhardwaj, Debolina D. Biswas, Tomasz Kordula, Kurt F. Hauser, Sandeep Singh, Jessie W. Yester, Michael R. Waters, Brendan F. Boyce, Michael J. Surace
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 194(6)
The secreted protein, YKL-40, has been proposed as a biomarker of a variety of human diseases characterized by ongoing inflammation, including chronic neurologic pathologies such as multiple sclerosis and Alzheimer’s disease. However, inflammatory
Autor:
Michael J, Surace, Liwu, Li
Publikováno v:
American journal of clinical and experimental immunology. 2(1)
Macrophages can respond to diverse signals and adopt multiple phenotypes. Although interleukin-4 (IL-4) is shown to potently induce the expression of arginase 1 and contribute to differentiation of macrophages to the anti-inflammatory M2 phenotype, o
Autor:
Michelle L. Block, Michael J. Surace
Publikováno v:
Cellular and molecular life sciences : CMLS. 69(14)
Microglia are key sentinels of central nervous system health, and their dysfunction has been widely implicated in the progressive nature of neurodegenerative diseases. While microglia can produce a host of factors that are toxic to neighboring neuron