Výsledky vyhledávání - "Michael J. Stower"

Data from JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells

Autor: Anne T. Collins, Norman J. Maitland, Pui-Kai Li, Chenglong Li, Somsundaram Chettiar, Deepak Bhasin, Matthew Simms, Vincent M. Mann, Greta Rodrigues, Michael J. Stower, Paul A. Berry, Paula Kroon

Interleukin (IL)-6 overexpression and constitutive STAT3 activation occur in many cancers, including prostate cancer. However, their contribution to prostate stem and progenitor cells has not been explored. In this study, we show that stem-like cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3759079a1cd74807e03543c8d654275f
https://doi.org/10.1158/0008-5472.c.6506609

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Supplementary Figure from JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells

PDF file, 7896K, A. Histology of mouse xenograft. H&E stain of a mouse xenograft derived from a patient with castrate-resistant prostate cancer. Small glandular structures are apparent with large, prominent nucleoli within sheets of undifferentiated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b53d35697d0aaec54104f3fe6aec43
https://doi.org/10.1158/0008-5472.22404455.v1

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Akademický článek

Differential cytotoxic activity of a novel palladium-based compound on prostate cell lines, primary prostate epithelial cells and prostate stem cells.

Autor: Engin Ulukaya, Fiona M Frame, Buse Cevatemre, Davide Pellacani, Hannah Walker, Vincent M Mann, Matthew S Simms, Michael J Stower, Veysel T Yilmaz, Norman J Maitland

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64278 (2013)

The outcome for patients with advanced metastatic and recurrent prostate cancer is still poor. Therefore, new chemotherapeutics are required, especially for killing cancer stem cells that are thought to be responsible for disease recurrence. In this

Externí odkaz: https://doaj.org/article/fa2ab04b61094a7daa200d16cc8d7ccd

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The Prevalence of Chronic Kidney Disease Requiring Nephrological Referral in Patients with Non-Visible Haematuria

Autor: Joby Taylor, Graeme H. Urwin, J. Russell Wilson, Michael J. Stower, Koon. H. Chan

Publikováno v: British Journal of Medical and Surgical Urology. 4:197-201

Objective: To quantify the proportion of patients attending for urological investigation of non-visible haematuria who meet criteria for referral to specialist renal services under current UK guidelines. Patients and methods: Data were collected from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8abef0820a625d315ca63d321222f9b9
https://doi.org/10.1016/j.bjmsu.2011.01.002

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Three-Year Outcomes of a Visible Haematuria Clinic—No Initial Role for Urine Cytology?

Autor: Graeme H. Urwin, J. Russell Wilson, Michael J. Stower, Nicholas. P. Munro, Koon. H. Chan

Publikováno v: British Journal of Medical and Surgical Urology. 3:204-209

Objective: To review patients presenting in a specialist macroscopic (visible) haematuria clinic during 2005, incorporating 3 years of follow-up, and to assess the role of urine cytology. Patients and methods: All patients attending the 2005 macrosco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec3ef1a92023b3ccfd629b6c7d026560
https://doi.org/10.1016/j.bjmsu.2010.04.002

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Prospective Identification of Tumorigenic Prostate Cancer Stem Cells

Autor: Catherine Hyde, Paul A. Berry, Norman J. Maitland, Michael J. Stower, Anne T. Collins

Publikováno v: Cancer Research. 65:10946-10951

Existing therapies for prostate cancer eradicates the bulk of cells within a tumor. However, most patients go on to develop androgen-independent disease that remains incurable by current treatment strategies. There is now increasing evidence in some

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa65a2c80e151167c79d04fe3e7576f7
https://doi.org/10.1158/0008-5472.can-05-2018

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Activation of Peroxisome Proliferator-Activated Receptor-γ Reverses Squamous Metaplasia and Induces Transitional Differentiation in Normal Human Urothelial Cells

Autor: Barbara A. Smith, Jens Stahlschmidt, Jennifer Southgate, Claire L. Varley, Michael J. Stower

Publikováno v: The American Journal of Pathology. 164:1789-1798

We observed that in urothelium, both cornifying and noncornifying forms of squamous metaplasia are accompanied by changes in the localization of the nuclear hormone receptors, peroxisome proliferator activated receptor gamma (PPAR-gamma) and retinoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc11a00da73dcaf82bbbecb339b7a354
https://doi.org/10.1016/s0002-9440(10)63737-6

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Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma

Autor: Shona H. Lang, Ian S. Hitchcock, Jean-Marie Villette, Michael J. Stower, A. A. Gordon Bryden, Catherine Hyde, Ian N. Reid, Norman J. Maitland, Claire A Hart

Publikováno v: The Prostate. 52:253-263

BACKGROUND. The metastatic potential of a series of prostate cell lines was analysed bymeasuring motility and invasiveness, and further correlated to the expression of epithelialdifferentiation markers.METHODS. Invasion and motility were measured usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049284f76e84984ef1676f3947e78da0
https://doi.org/10.1002/pros.10088

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