Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Michael J. Sofia"'
Autor:
Angela M. Lam, Ravi R. Dugyala, Muhammed Sheraz, Fei Liu, Emily P. Thi, Ingrid E. Graves, Andrea Cuconati, Holly Micolochick Steuer, Andrzej Ardzinski, Nathan Overholt, Jeremy D. Mason, Dimitar Gotchev, Andrew G. Cole, Troy O. Harasym, Michael J. Sofia
Publikováno v:
Viruses, Vol 16, Iss 3, p 323 (2024)
HBV RNA destabilizers are a class of small-molecule compounds that target the noncanonical poly(A) RNA polymerases PAPD5 and PAPD7, resulting in HBV RNA degradation and the suppression of viral proteins including the hepatitis B surface antigen (HBsA
Externí odkaz:
https://doaj.org/article/0908b4ef0b784f98b382f882d0593288
Autor:
Man‐Fung Yuen, Elina Berliba, Wattana Sukeepaisarnjaroen, Sang Hoon Ahn, Tawesak Tanwandee, Young‐Suk Lim, Yoon Jun Kim, Kittiyod Poovorawan, Pisit Tangkijvanich, Christian Schwabe, Timothy Eley, Joanne Brown, Amy C. H. Lee, Emily P. Thi, Bhavna Paratala, Nagraj Mani, Michael J. Sofia, Gaston Picchio, Karen D. Sims, Edward J. Gane
Publikováno v:
Hepatology Communications, Vol 6, Iss 12, Pp 3457-3472 (2022)
Abstract AB‐506 is a potent, pan‐genotypic small molecule capsid inhibitor that inhibits hepatitis B virus (HBV) pregenomic RNA encapsidation. We assessed the safety, pharmacokinetics, and antiviral activity of AB‐506 in two randomized, double
Externí odkaz:
https://doaj.org/article/6ea02a9ddc574a2288f20604466e8868
Autor:
Jang-June Park, Emily P. Thi, Victor H. Carpio, Yingzhi Bi, Andrew G. Cole, Bruce D. Dorsey, Kristi Fan, Troy Harasym, Christina L. Iott, Salam Kadhim, Jin Hyang Kim, Amy C. H. Lee, Duyan Nguyen, Bhavna S. Paratala, Ruiqing Qiu, Andre White, Damodharan Lakshminarasimhan, Christopher Leo, Robert K. Suto, Rene Rijnbrand, Sunny Tang, Michael J. Sofia, Chris B. Moore
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Programmed death-ligand 1 (PD-L1) is involved in the inhibition of antigen specific T cells via ligation of programmed death 1 (PD-1). Here, the authors show checkpoint inhibition by use of small molecule inhibition of PD-L1 which in a humanised mous
Externí odkaz:
https://doaj.org/article/cbf4ada82c004c6dad7c4c374ea066bb
Autor:
Michael J. Sofia, Xuechen Li
Publikováno v:
RSC medicinal chemistry. 13(9)
Guest editors Michael J. Sofia and Xuechen Li introduce the themed collection on antibiotic and antiviral compounds.
Autor:
Qiong Zhao, Jinhong Chang, Rene Rijnbrand, Angela M. Lam, Michael J. Sofia, Andrea Cuconati, Ju-Tao Guo
Publikováno v:
J Virol
Hepatitis B virus (HBV) replicates its genomic DNA by reverse transcription of an RNA intermediate, termed pregenomic RNA (pgRNA), within nucleocapsid. It had been shown that transfection of in vitro-transcribed pgRNA initiated viral replication in h
Autor:
Michael J. Sofia
Publikováno v:
New Drug Development for Known and Emerging Viruses. :13-57
Autor:
Andrew G. Cole, Steven G. Kultgen, Nagraj Mani, Andrzej Ardzinski, Kristi Yi Fan, Emily P. Thi, Bruce D. Dorsey, Kim Stever, Tim Chiu, Sunny Tang, Owen Daly, Janet R. Phelps, Troy Harasym, Andrea Olland, Robert K. Suto, Michael J. Sofia
Publikováno v:
RSC Med Chem
Disruption of the HBV viral life cycle with small molecules that prevent the encapsidation of pregenomic RNA and viral polymerase through binding to HBV core protein is a clinically validated approach to inhibiting HBV viral replication. Herein we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3d746e0df2833c3377ff3c4df6151d
https://europepmc.org/articles/PMC8942244/
https://europepmc.org/articles/PMC8942244/
Autor:
Edward J Gane, Alina Jucov, Liudmyla Kolomiichuk, Timothy Eley, Joanne Brown, Yele King, Elina Medvedeva, Maksym Chernyakhovskyy, Nagraj Mani, Andrew G. Cole, Steven G. Kultgen, Reddy Pamulapati, Emily P. Thi, Troy O. Harasym, Ravi Dugyala, Sachin Chaudhari, Michael J. Sofia, Michael Child, Gaston Picchio, Karen Sims, Man-Fung Yuen
Publikováno v:
Journal of Hepatology. 77:S848-S849
Autor:
Kristi Fan, Andrea Cuconati, Robbin Burns, Xiaowei Teng, Amy C.H. Lee, Nagraj Mani, Ellen Evangelista, Bruce D. Dorsey, Sunny Tang, Salam Kadhim, Roseann Kowalski, Angela Miller, Troy Harasym, Janet R. Phelps, Kim Stever, Andrzej Ardzinski, Alice H. Li, Chris Pasetka, Rene Rijnbrand, Andrew G. Cole, Holly M. Micolochick Steuer, Stephen P. Reid, Steven G. Kultgen, Michael J. Sofia, Xiaohe Wang, Tim T. Chiu, Sara A. Majeski, Fang Guo
Publikováno v:
Antiviral research. 197
AB-506, a small-molecule inhibitor targeting the HBV core protein, inhibits viral replication in vitro (HepAD38 cells: EC50 of 0.077 μM, CC50 > 25 μM) and in vivo (HBV mouse model: ∼3.0 log10 reductions in serum HBV DNA compared to the vehicle co
Autor:
Emily P. Thi, Andrew G. Cole, Gavin Heffernan, Christina Iott, Seyma Ozturk, Sharie C Ganchua, Dan Nguyen, Ingrid Graves, Vijay Ahuja, Kim Stever, Kristi Fan, Jorge G. Quintero, Steven G. Kultgen, Maria Shubina, Boya Liu, Sunny Tang, Troy O. Harasym, Angela M Lam, Michael J. Sofia
Publikováno v:
Journal of Hepatology. 77:S848