Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Michael J. Soares"'
Autor:
Kaela M. Varberg, Esteban M. Dominguez, Boryana Koseva, Joseph M. Varberg, Ross P. McNally, Ayelen Moreno-Irusta, Emily R. Wesley, Khursheed Iqbal, Warren A. Cheung, Carl Schwendinger-Schreck, Craig Smail, Hiroaki Okae, Takahiro Arima, Michael Lydic, Kristin Holoch, Courtney Marsh, Michael J. Soares, Elin Grundberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract The extravillous trophoblast cell lineage is a key feature of placentation and successful pregnancy. Knowledge of transcriptional regulation driving extravillous trophoblast cell development is limited. Here, we map the transcriptome and epi
Externí odkaz:
https://doaj.org/article/32af357bf3224b598ca6146e0d2f58e5
Autor:
Prashanth Anamthathmakula, Philemon D. Shallie, Neha Nayak, Sabita Dhal, Jay L. Vivian, Gil Mor, Michael J. Soares, Nihar R. Nayak
Publikováno v:
Cells, Vol 12, Iss 16, p 2096 (2023)
The aromatase-Cre recombinase (Cyp19-Cre) transgenic mouse model has been extensively used for placenta-specific gene inactivation. In a pilot study, we observed unexpected phenotypes using this mouse strain, which prompted an extensive characterizat
Externí odkaz:
https://doaj.org/article/23884fd26a6147faa481f3144cb710c8
Autor:
Geetu Tuteja, Michael J. Soares
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/424021004e07434383f42459330a986e
Autor:
Vinay Shukla, Michael J. Soares
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 2947 (2022)
The rat possesses hemochorial placentation with deep intrauterine trophoblast cell invasion and trophoblast-guided uterine spiral artery remodeling, which resembles human placentation. Uterine spiral arteries are extensively remodeled to deliver suff
Externí odkaz:
https://doaj.org/article/4b8ff981f0794b728dd17b7cd46a3b22
Autor:
Pramod Dhakal, Michael J. Soares
Publikováno v:
BioTechniques, Vol 62, Iss 5, Pp 232-233 (2017)
The advent of genome editing strategies has expanded the range of animal models available for gene manipulation and renewed research interest in the rat. Gender is a key variable for in vivo gene function analyses. Here, we present a simple PCR-based
Externí odkaz:
https://doaj.org/article/91057f864e02430fb053337a04203e8d
Autor:
L. Rhiannon Hilton, Matthew T. Rätsep, M. Martin VandenBroek, Salema Jafri, Kimberly J. Laverty, Melissa Mitchell, Anne L. Theilmann, James A. Smart, Lindsey G. Hawke, Stephen D. Moore, Stephen J. Renaud, Michael J. Soares, Nicholas W. Morrell, Mark L. Ormiston
Publikováno v:
Hypertension. 79:2493-2504
Background: Natural killer (NK) cell impairment is a feature of pulmonary arterial hypertension (PAH) and contributes to vascular remodeling in animal models of disease. Although mutations in BMPR2 , the gene encoding the BMP (bone morphogenetic prot
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(41)
The hemochorial placentation site is characterized by a dynamic interplay between trophoblast cells and maternal cells. These cells cooperate to establish an interface required for nutrient delivery to promote fetal growth. In the human, trophoblast
The invasive trophoblast cell lineage in rat and human share crucial responsibilities in establishing the uterine-placental interface of the hemochorial placenta. These observations have led to the rat becoming an especially useful animal model to st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7e3303406fd67fd7f9019d1155cefe7
https://doi.org/10.1101/2023.03.30.534962
https://doi.org/10.1101/2023.03.30.534962
Autor:
Keisuke Kozai, Ayelen Moreno-Irusta, Khursheed Iqbal, Mae-Lan Winchester, Regan L. Scott, Mikaela E. Simon, Masanaga Muto, Marc R. Parrish, Michael J. Soares
Publikováno v:
Development. 150
Hemochorial placentation involves the differentiation of invasive trophoblast cells, specialized cells that possess the capacity to exit the placenta and invade into the uterus where they restructure the vasculature. Invasive trophoblast cells arise
Autor:
Marija Kuna, Pramod Dhakal, Khursheed Iqbal, Esteban M. Dominguez, Lindsey N. Kent, Masanaga Muto, Ayelen Moreno-Irusta, Keisuke Kozai, Kaela M. Varberg, Hiroaki Okae, Takahiro Arima, Henry M. Sucov, Michael J. Soares
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Establishment of the hemochorial uterine–placental interface requires exodus of trophoblast cells from the placenta and their transformative actions on the uterus, which represent processes critical for a successful pregnancy, but are poorly unders