Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Michael J. Skibic"'
Publikováno v:
Molecular Pharmaceutics. 7:1508-1515
Changes in in vitro drug release profiles of oral dosage forms are commonly observed due to storage of drug product at elevated temperature and humidity. An example is presented of an immediate release drug product which underwent changes to both rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed85727b13d631e39b6fea688c948f6
https://doi.org/10.1021/mp1001476
https://doi.org/10.1021/mp1001476
Autor:
Jose M. Cintron, Jibo Wang, Ian A. Watson, Michael J. Skibic, Hai Bui, Chunlei Wang, Richard E. Higgs
Publikováno v:
Journal of Chromatography A. 1216:5030-5038
Quantitative structure-retention relationship (QSRR) models were studied for two databases: one with 151 compounds and the other with 1719 compounds. In both cases, the three modeling methods employed (multiple linear regression, partial least square
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bba2de2bed98820afd413b25c321f94
https://doi.org/10.1016/j.chroma.2009.04.064
https://doi.org/10.1016/j.chroma.2009.04.064
Autor:
Lloyd R. Snyder, Michael J. Skibic, Loren Wrisley, Kallol M. Biswas, Kevin A. Wells, N.P. Toltl, Robert A. Reed, Patrick Lukulay, M. Ma, Yun Mao, William E. Bowen, Chi Chiu Chan, K. Medwid, R.C. Munger, Jackson Pellett, John W. Dolan
Publikováno v:
Journal of Chromatography A. 1101:122-135
A general procedure is proposed for the rapid development of a reversed-phase liquid chromatographic (RP-LC) separation that is "orthogonal" to a pre-existing ("primary") method for the RP-LC separation of a given sample. The procedure involves a cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d165bfd3a228fe598d06cb5057dbd62
https://doi.org/10.1016/j.chroma.2005.09.080
https://doi.org/10.1016/j.chroma.2005.09.080
Autor:
Michael J. Skibic, Leslie J. Lorenz, John L. Occolowitz, Steven W. Baertschi, Douglas E. Dorman, K. Wayne Taylor, Larry A. Spangle, John W. Paschal, Monte W. Collins
Publikováno v:
Journal of Pharmaceutical Sciences. 82:1010-1017
The aqueous degradation of the carbacephalosporin loracarbef under moderately acidic conditions (pH range, 2.7-4.3) is described. Structures of a total of 10 compounds isolated by preparative reversed-phase HPLC have been proposed. Five of these 10 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1db3a6848a966ab421227a927f41c27
https://doi.org/10.1002/jps.2600821002
https://doi.org/10.1002/jps.2600821002
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 53(3)
Duloxetine hydrochloride, a secondary amine containing pharmaceutical, currently marketed as Cymbalta™, is shown to undergo N-formylation as an artifact of sample preparation prior to HPLC analysis for impurities. The reaction was discovered as a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92879a44c99294170a56175629f204d
https://pubmed.ncbi.nlm.nih.gov/20570459
https://pubmed.ncbi.nlm.nih.gov/20570459
Autor:
Paul B. Wright, Bryan C. Castle, Michael J. Skibic, Donald S. Risley, Kallol M. Biswas, Bernard A. Olsen
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 49(3)
The development and utility of an efficient HPLC method screening strategy using only four columns for the separation of pharmaceutical compounds and related impurities is presented. The strategy established a two-column approach to enable rapid earl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530993d31653a4ee18052e82280caa2b
https://pubmed.ncbi.nlm.nih.gov/19181471
https://pubmed.ncbi.nlm.nih.gov/19181471