Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Michael J. Shields"'
Autor:
Kingsley K. Amoako, Michael J. Shields, Noriko Goji, Chantal Paquet, Matthew C. Thomas, Timothy W. Janzen, Cesar I. Bin Kingombe, Arnold J. Kell, Kristen R. Hahn
Publikováno v:
Journal of Pathogens, Vol 2012 (2012)
Interest has recently been renewed in the possible use of Y. pestis, the causative agent of plague, as a biological weapon by terrorists. The vulnerability of food to intentional contamination coupled with reports of humans having acquired plague thr
Externí odkaz:
https://doaj.org/article/5fb92c552e804f51bf22b8db9329c6c5
Autor:
Matthew C. Thomas, Timothy W. Janzen, Kingsley K. Amoako, Noriko Goji, Michael J. Shields, Kristen R. Hahn
Publikováno v:
International Journal of Food Microbiology. 165:319-325
The development of advanced methodologies for the detection of Bacillus anthracis has been evolving rapidly since the release of the anthrax spores in the mail in 2001. Recent advances in detection and identification techniques could prove to be an e
Evaluation of DNA extraction methods for Bacillus anthracis spores isolated from spiked food samples
Autor:
Kristen R. Hahn, Noriko Goji, Michael J. Shields, Matthew C. Thomas, Timothy W. Janzen, Kingsley K. Amoako
Publikováno v:
Journal of Applied Microbiology. 115:156-162
Aims Nine commercial DNA extraction kits were evaluated for the isolation of DNA from 10-fold serial dilutions of Bacillus anthracis spores using quantitative real-time PCR (qPCR). The three kits determined by qPCR to yield the most sensitive and con
Autor:
Shey Eagle Bear, Hans-Joachim Wieden, Mackenzie L. Coatham, Evelina Ines De Laurentiis, Harland E. Brandon, Michael J. Shields, Jeffrey J. Fischer
Publikováno v:
Biochimie. 94:1647-1659
The universally conserved GTPase HflX is a putative translation factor whose GTPase activity is stimulated by the 70S ribosome as well as the 50S but not the 30S ribosomal subunit. However, the details and mechanisms governing this interaction are on
Autor:
Joselyn Del Rosario, Michelle Parish, Bin Liu, Jie Huang, Ping Jin, Dingguo Liu, Marla J. Matin, Gary Woodnutt, Bryan Oates, Jing-Yu Lai, Nancy Levin, Rodney W. Lappe, Curt W. Bradshaw, Richard A. Lerner, Crystal Hagen, Abhijit Bhat, Robert E. Murphy, Zemeda W Ainekulu, Michael J. Shields, Venkata Doppalapudi, Lingna Li, Joel Desharnais
Publikováno v:
Proceedings of the National Academy of Sciences. 107:22611-22616
Bispecific antibodies (BsAbs) are regarded as promising therapeutic agents due to their ability to simultaneously bind two different antigens. Several bispecific modalities have been developed, but their utility is limited due to problems with stabil
Autor:
Timothy W. Janzen, Noriko Goji, Michael J. Shields, Matthew C. Thomas, Kristen R. Hahn, Kingsley K. Amoako
Publikováno v:
Journal of food protection. 78(2)
Bacillus anthracis, the causative agent of anthrax, has the capacity to form highly resilient spores as part of its life cycle. The potential for the dissemination of these spores using food as a vehicle is a huge public health concern and, hence, re
Publikováno v:
Journal of Food Protection. 76:699-701
Bacillus anthracis Sterne strain spores were analyzed for their resistance against five disinfectants: commercial sodium hypochlorite, Spor-Klenz Ready-to-Use Cold Sterilant, accelerated hydrogen peroxide (AHP), Virkon, and surface decontamination fo
Publikováno v:
Molecular Immunology. 36:561-573
Dynamic interactions between major histocompatibility complex (MHC) class I heavy chains and beta2-microglobulin (beta2m) play a critical role in their stability on the cell surface, and their ability to present peptide antigens to CD8+ T-cells. A cu
Publikováno v:
The Journal of Immunology. 160:2297-2307
Human β2m (hβ2m) binds to murine MHC I molecules with higher affinity than does murine β2m and therefore can be used as a model system to define and dissect the interactions between β2m and MHC I heavy chains that promote the stability of the com
Autor:
Timothy W. Janzen, Michael J. Shields, Edith Valle, Kristen R. Hahn, Kingsley K. Amoako, Noriko Goji, Matthew C. Thomas
Publikováno v:
Veterinary microbiology. 169(3-4)
Several technology platforms have been developed to resolve the phylogenetic placement of B. anthracis. However, these methods lack the resolution to identify differences between closely related strains within an outbreak due to the highly clonal nat