Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Michael J. Sheedlo"'
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010720 (2022)
Bacterial type IV secretion systems (T4SSs) are a versatile group of nanomachines that can horizontally transfer DNA through conjugation and deliver effector proteins into a wide range of target cells. The components of T4SSs in gram-negative bacteri
Externí odkaz:
https://doaj.org/article/5f1b0c4e0e2e44808f1e742f81f9e4a2
Autor:
Michael J Sheedlo, Clarissa L Durie, Jeong Min Chung, Louise Chang, Jacquelyn Roberts, Michele Swanson, Dana Borden Lacy, Melanie D Ohi
Publikováno v:
eLife, Vol 10 (2021)
Legionella pneumophila is an opportunistic pathogen that causes the potentially fatal pneumonia known as Legionnaires’ disease. The pathology associated with infection depends on bacterial delivery of effector proteins into the host via the membran
Externí odkaz:
https://doaj.org/article/769fbc40a033482aa6d6f369888cccee
Autor:
Michael J Sheedlo, Jeong Min Chung, Neha Sawhney, Clarissa L Durie, Timothy L Cover, Melanie D Ohi, D Borden Lacy
Publikováno v:
eLife, Vol 9 (2020)
The pathogenesis of Helicobacter pylori-associated gastric cancer is dependent on delivery of CagA into host cells through a type IV secretion system (T4SS). The H. pylori Cag T4SS includes a large membrane-spanning core complex containing five prote
Externí odkaz:
https://doaj.org/article/1dde8d85688348948d757c443b00197a
Autor:
Clarissa L Durie, Michael J Sheedlo, Jeong Min Chung, Brenda G Byrne, Min Su, Thomas Knight, Michele Swanson, D Borden Lacy, Melanie D Ohi
Publikováno v:
eLife, Vol 9 (2020)
Legionella pneumophila is an opportunistic pathogen that causes the potentially fatal pneumonia Legionnaires’ Disease. This infection and subsequent pathology require the Dot/Icm Type IV Secretion System (T4SS) to deliver effector proteins into hos
Externí odkaz:
https://doaj.org/article/4e727e751c3643ba8cf52314be90d2c1
Autor:
Jeong Min Chung, Michael J Sheedlo, Anne M Campbell, Neha Sawhney, Arwen E Frick-Cheng, Dana Borden Lacy, Timothy L Cover, Melanie D Ohi
Publikováno v:
eLife, Vol 8 (2019)
Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Helicobacter pylori Cag T4SS translocates CagA, a bacterial on
Externí odkaz:
https://doaj.org/article/a09e84dbd1fd47248cd182384fd9c270
Autor:
Dena Lyras, John A. Shupe, Jaime L. Jensen, Michael J Sheedlo, Ashleigh P. Rogers, Sarah C. Bloch, Steven J. Mileto, Melanie L. Hutton, Simon Wilkins, Kevin O. Childress, Genevieve Kerr, D. Borden Lacy, Rebekah Engel, Paul J. McMurrick, Thierry Jarde, Katja Horvay, Tracey J. Flores, Helen E. Abud
Publikováno v:
Proc Natl Acad Sci U S A
Gastrointestinal infections often induce epithelial damage that must be repaired for optimal gut function. While intestinal stem cells are critical for this regeneration process [R. C. van der Wath, B. S. Gardiner, A. W. Burgess, D. W. Smith, PLoS On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63a59301301e5ccaa8a9f1761b473d4
https://doi.org/10.1073/pnas.1915255117
https://doi.org/10.1073/pnas.1915255117
Publikováno v:
Proceedings of the National Academy of Sciences. 117:6139-6144
Clostridioides difficile is a Gram-positive, pathogenic bacterium and a prominent cause of hospital-acquired diarrhea in the United States. The symptoms of C. difficile infection are caused by the activity of three large toxins known as toxin A (TcdA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc2d531d9f70e452dac8e9179b3a4ac4
https://doi.org/10.1073/pnas.1920555117
https://doi.org/10.1073/pnas.1920555117
Autor:
Jeong Min Chung, Louise Chang, Michael J Sheedlo, Melanie D. Ohi, Michele S. Swanson, Clarissa L Durie, Jacquelyn Roberts, D.B. Lacy
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Legionella pneumophila is an opportunistic pathogen that causes the potentially fatal pneumonia known as Legionnaires’ disease. The pathology associated with infection depends on bacterial delivery of effector proteins into the host via the membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98a7de1fb54c7e44b4aad55012f7169
https://doi.org/10.7554/elife.70427
https://doi.org/10.7554/elife.70427
Publikováno v:
Nature microbiology
Clostridioides (formerly Clostridium) difficile is a Gram-positive, spore-forming anaerobe and a leading cause of hospital-acquired infection and gastroenteritis-associated death in US hospitals1. The disease state is usually preceded by disruption o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44327e80d248808994454c7fd14ac7d
https://doi.org/10.1038/s41564-019-0601-8
https://doi.org/10.1038/s41564-019-0601-8