Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michael J. Schmitt"'
Autor:
Jenny Ying-Lin Lu, Jonathan B. Houze, Rajiv Sharma, Michael J. Schmitt, Jeff D. Reagan, Kathy Nguyen, Hui Tian, Ying Sun, Jinqian Liu, Yang Li, Daniel C.-H. Lin, Liang Tang, Wei Qiu, Michael Chen, Steven J. Shuttleworth, Yingcai Wang, Alex Zhang, George Tonn, Edwin Lopez, Jiwen Liu, Michelle Akerman, Julio C. Medina, Liusheng Zhu, Jian Luo, Jane Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1267-1270
The discovery that certain long chain fatty acids potentiate glucose stimulated insulin secretion through the previously orphan receptor GPR40 sparked interest in GPR40 agonists as potential antidiabetic agents. Optimization of a series of β-substit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf658a372d0b395d425e7df4ade3df1
https://doi.org/10.1016/j.bmcl.2011.10.118
https://doi.org/10.1016/j.bmcl.2011.10.118
Publikováno v:
Tetrahedron. 59:5623-5634
The cyclopropyl group has played and continues to play a prominent role in organic chemistry. Its strained structure, interesting bonding characteristics, and value as an internal mechanistic probe have drawn the attention of the physical organic com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eac6ea773b132d8ee9fb5bdde7af953
https://doi.org/10.1016/s0040-4020(03)00880-9
https://doi.org/10.1016/s0040-4020(03)00880-9
Publikováno v:
Journal of the American Chemical Society. 123:2964-2969
Practical and efficient routes for the stereoselective conversion of homoallylic alchols to diastereomerically pure cis-, trans-1,2-disubstituted, and 1,2,3-trisubstituted cyclopropanes have been developed. The routes are highlighted by olefin metath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54ad4191f85cace22ff90165ae8efb0e
https://doi.org/10.1021/ja0037163
https://doi.org/10.1021/ja0037163
Publikováno v:
Tetrahedron Letters. 49:7284-7286
A mild and efficient method for the preparation of substituted benzimidazoles from 1,1-dibromoethenes and o-diaminobenzenes is described. The reaction employs DABCO as the base and NMP as the solvent. A variety of substitutions on both 2-aryl-1,1-dib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01353ee2df940d9f18d65f301d11dc78
https://doi.org/10.1016/j.tetlet.2008.10.030
https://doi.org/10.1016/j.tetlet.2008.10.030
Publikováno v:
Organic Letters. 5:1377-1379
[reaction: see text] An efficient two-step homologation of aldehydes to cyclopropylaldehydes has been developed. Activation of homoaldol adducts derived from O-enecarbamates and N-enecarbamates provided high yields of cyclopropylaldehydes with good t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2eb727f8e6a20deb20ab68b4c79e17
https://doi.org/10.1021/ol034448r
https://doi.org/10.1021/ol034448r
Autor:
Michael J. Schmitt, Xuemei Wang, Alison L. Budelsky, Julio C. Medina, Wang Shen, H Lucy Tang, Jiwen Jim Liu, Derek Marshall, Tassie L. Collins, Tod Martin, Zice Fu, Yingcai Wang, Erika Rickel
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
We have previously reported that optimization of a series of phenylacetic acid derivatives led to the discovery of CRTH2 and DP dual antagonists, such as AMG 009 and AMG 853. During the optimization process, we discovered that minor structural modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5c35e3cc5a5a4823987e85abc53a25
https://pubmed.ncbi.nlm.nih.gov/22119474
https://pubmed.ncbi.nlm.nih.gov/22119474
Publikováno v:
ChemInform. 31
A practical and efficient route for the stereoselective conversion of easily accessible homoallylic alcohols to diastereomerically pure cis- and trans-disubstituted and 1,2,3-trisubstituted cyclopropanes has been developed. The diversity of structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7cf8bd3cdd2c681b8fd96bde8d54e62
https://doi.org/10.1002/chin.200025080
https://doi.org/10.1002/chin.200025080
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a199b5c6dcd846788d093c50038cc0f
https://doi.org/10.1002/chin.200126034
https://doi.org/10.1002/chin.200126034
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3629c112f3eb68c18638c309826988af
https://doi.org/10.1002/chin.200144081
https://doi.org/10.1002/chin.200144081
Publikováno v:
ChemInform. 40
A mild and efficient method for the preparation of substituted benzimidazoles from 1,1-dibromoethenes and o-diaminobenzenes is described. The reaction employs DABCO as the base and NMP as the solvent. A variety of substitutions on both 2-aryl-1,1-dib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fea08af7a4e44a3fe3aa030d92a2efdc
https://doi.org/10.1002/chin.200913114
https://doi.org/10.1002/chin.200913114