Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michael J. Santostefano"'
Autor:
Sarah R, Nesfield, Thomas C, Williams, Debie J, Hoivik, Richard T, Miller, Jane S, Allen, Krzysztof, Selinger, Douglas, Rickert, Michael J, Santostefano
Publikováno v:
International Journal of Toxicology. 24:341-348
This study was conducted in support of the International Life Sciences Institute (ILSI) alternative carcinogenicity models initiative to evaluate the carcinogenic potential of clofibrate, a nongenotoxic peroxisome proliferator-activated receptor (PPA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6c35bc93c215fef7f4085833a0cd92
https://doi.org/10.1080/10915810500210401
https://doi.org/10.1080/10915810500210401
Autor:
Carla E, Torrey, Henry G, Wall, James A, Campbell, Puntipa, Kwanyuen, Debie J, Hoivik, Richard T, Miller, Jane S, Allen, Manuel J, Jayo, Krzysztof, Selinger, Michael J, Santostefano
Publikováno v:
International Journal of Toxicology. 24:327-339
This study was conducted as part of the International Life Sciences Institute (ILSI) Alternatives to Carcinogenicity Testing program and evaluated the carcinogenic potential of clofibrate, a nongenotoxic, peroxisome proliferator-activated receptor (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a967949b5a64e23076c03313a5c0a6
https://doi.org/10.1080/10915810500208199
https://doi.org/10.1080/10915810500208199
Autor:
Carla E, Torrey, James A, Campbell, Debie J, Hoivik, Richard T, Miller, Jane S, Allen, Peter C, Mann, Krzysztof, Selinger, Douglas, Rickert, Paul M, Savina, Michael J, Santostefano
Publikováno v:
International Journal of Toxicology. 24:289-299
This study was conducted as part of International Life Sciences Institute (ILSI) program to evaluate the carcinogenic potential of clofibrate, a nongenotoxic, peroxisome proliferator-activated receptor (PPAR) α agonist, following oral administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2128e2cf98ea75fd990c0a09d76b269e
https://doi.org/10.1080/10915810500210237
https://doi.org/10.1080/10915810500210237
Autor:
Jane S. Allen, Michael J. Santostefano, Sarah R. Nesfield, Debie J. Hoivik, Douglas Rickert, Thomas C. Williams, Krzysztof Selinger, Richard T. Miller
Publikováno v:
International Journal of Toxicology. 24:301-311
The purpose of the study was to support of the International Life Sciences Institute (ILSI) alternative carcinogenicity models initiative to evaluate the carcinogenic potential of the nongenotoxic carcinogen, clofibrate, a peroxisome proliferator-act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1fd8b5c5d4423909fa50378e1b7ff9
https://doi.org/10.1080/10915810500210278
https://doi.org/10.1080/10915810500210278
Publikováno v:
Toxicological Sciences. 56:49-60
A physiologically based pharmacodynamic (PBPK) model for 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) was developed based on pharmacokinetic data from acute oral exposures of TCDD to female Sprague-Dawley rats (Wang et al., 1997, Toxicol Appl. Pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e1592522b7375bc6894554e170e312
https://doi.org/10.1093/toxsci/56.1.49
https://doi.org/10.1093/toxsci/56.1.49
Publikováno v:
Biochemical and Biophysical Research Communications. 252:225-231
The aryl hydrocarbon receptor (AhR) shares a common PAS domain with a number of genes that exhibit a pronounced circadian rhythm. Therefore, this study examined the daily cycle of AhR and AhR nuclear translocator (Arnt) protein expression in multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8764a771e93adeef8c7554c6252111
https://doi.org/10.1006/bbrc.1998.9634
https://doi.org/10.1006/bbrc.1998.9634
Autor:
Xiaofeng Wang, Michael J. Santostefano, David G. Ross, Linda S. Birnbaum, Vicki M. Richardson, Michael J. DeVito
Publikováno v:
Toxicology and Applied Pharmacology. 151:294-310
The ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) to alter gene expression and the demonstration that the induction of CYP1A2 is responsible for hepatic TCDD sequestration suggest that both pharmacokinetic and pharmacodynamic events m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fac38c99ea2ff67c3e2768d57cab4f
https://doi.org/10.1006/taap.1998.8466
https://doi.org/10.1006/taap.1998.8466
Autor:
Krista L. Johnson, Michael J. DeVito, Linda S. Birnbaum, Janet J. Diliberto, Vicki M. Richardson, Michael J. Santostefano, Nicole A. Whisnant
Publikováno v:
Fundamental and Applied Toxicology. 34:265-275
Subcellular localization of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds has been examined only in the liver. The objective of this study was (1) to examine and compare the subcellular distribution of TCDD within hepatic and nonhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d49b035238fcf1404b4274caa21e4a2
https://doi.org/10.1006/faat.1996.0196
https://doi.org/10.1006/faat.1996.0196
Autor:
MICHAEL J. SANTOSTEFANO, KRISTA L. JOHNSON, NICOLE A. WHISNANT, VICKI M. RICHARDSON, MICHAEL J. DEVITO, LINDA S. BIRNBAUM
Publikováno v:
Toxicological Sciences. 34:265-275
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4decc0bb7c9df887c947aaeffcffcbe7
https://doi.org/10.1093/toxsci/34.2.265
https://doi.org/10.1093/toxsci/34.2.265
Autor:
Dan A. Rock, Wei-Jian Pan, Michael J. Santostefano, Hugo M. Vargas, James F. Reindel, Duc Tran, Madeline M. Fort, Kai O. Reynhardt, Jacqueline A. Kirchner, Padma K. Narayanan, Remi Jawando, William A. Rees, Nancy E. Everds, Peter J. Prince, Sean Lear, Kelly Hensley, Christine Vissinga
Publikováno v:
Toxicologic pathology. 40(6)
AMG X, a human neutralizing monoclonal antibody (mAb) against a soluble human protein, caused thrombocytopenia, platelet activation, reduced mean arterial pressure, and transient loss of consciousness in cynomolgus monkeys after first intravenous adm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b455e0b072e4e10b74933b0f1af8bc
https://pubmed.ncbi.nlm.nih.gov/22552394
https://pubmed.ncbi.nlm.nih.gov/22552394