Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Michael J. Rynkiewicz"'
Autor:
Jenette G. Creso, Ilhan Gokhan, Michael J. Rynkiewicz, William Lehman, Jeffrey R. Moore, Stuart G. Campbell
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Dilated cardiomyopathy (DCM) is an inherited disorder often leading to severe heart failure. Linkage studies in affected families have revealed hundreds of different mutations that can cause DCM, with most occurring in genes associated with the cardi
Externí odkaz:
https://doaj.org/article/355e6c5f02564a29bfeacfe09de5bd03
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 3, Iss , Pp 100025- (2023)
Externí odkaz:
https://doaj.org/article/0b1cb2821fd84341b69ee14b6c6fdc4c
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Striated muscle contraction is regulated in a calcium-dependent manner through dynamic motions of the tropomyosin/troponin polymer, a multicomponent complex wrapped around actin-containing thin filaments. Tropomyosin/troponin sterically blocks myosin
Externí odkaz:
https://doaj.org/article/bca1339893fe4e4eb4dde02f068d2297
Autor:
Meera C. Viswanathan, William Schmidt, Peter Franz, Michael J. Rynkiewicz, Christopher S. Newhard, Aditi Madan, William Lehman, Douglas M. Swank, Matthias Preller, Anthony Cammarato
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The α-cardiac actin M305L hypertrophic cardiomyopathy-causing mutation is located near residues that help confine tropomyosin to an inhibitory position along thin filaments. Here the authors assessed M305L actin in vivo, in vitro, and in silico to c
Externí odkaz:
https://doaj.org/article/05ebaf72ecab4ca79c70cc1236244ddd
Autor:
Meera C. Viswanathan, William Schmidt, Michael J. Rynkiewicz, Karuna Agarwal, Jian Gao, Joseph Katz, William Lehman, Anthony Cammarato
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2612-2625 (2017)
Striated muscle contraction is regulated by the movement of tropomyosin over the thin filament surface, which blocks or exposes myosin binding sites on actin. Findings suggest that electrostatic contacts, particularly those between K326, K328, and R1
Externí odkaz:
https://doaj.org/article/670ed79f2a0145d4a9cd3d5f4cfa4db2
Autor:
Martin van Eijk, Marine L. B. Hillaire, Guus F. Rimmelzwaan, Michael J. Rynkiewicz, Mitchell R. White, Kevan L. Hartshorn, Martin Hessing, Peter A. Koolmees, Monique H. Tersteeg, Maarten H. van Es, Tjarko Meijerhof, Anke Huckriede, Henk P. Haagsman
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Innate immunity is critical in the early containment of influenza A virus (IAV) infection and surfactant protein D (SP-D) plays a crucial role in innate defense against IAV in the lungs. Multivalent lectin-mediated interactions of SP-D with IAVs resu
Externí odkaz:
https://doaj.org/article/0c84c4792fb344a28f97b08f77a05c7a
Publikováno v:
Structural Dynamics, Vol 3, Iss 1, Pp 012002-012002-11 (2016)
Coiled-coil tropomyosin binds to consecutive actin-subunits along actin-containing thin filaments. Tropomyosin molecules then polymerize head-to-tail to form cables that wrap helically around the filaments. Little is known about the assembly process
Externí odkaz:
https://doaj.org/article/af88fff3505b4f7a972249393001588c
Autor:
Matthew H. Doran, Michael J. Rynkiewicz, David Rasicci, Skylar M.L. Bodt, Meaghan E. Barry, Esther Bullitt, Christopher M. Yengo, Jeffrey R. Moore, William Lehman
Publikováno v:
Journal of General Physiology. 155
Following binding to the thin filament, β-cardiac myosin couples ATP-hydrolysis to conformational rearrangements in the myosin motor that drive myofilament sliding and cardiac ventricular contraction. However, key features of the cardiac-specific ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a6b6bf684fbbd474adf1942c0195791
https://doi.org/10.1085/jgp.202213267
https://doi.org/10.1085/jgp.202213267
Autor:
Matthew H. Doran, Michael J. Rynkiewicz, Elumalai Pavadai, Skylar M.L. Bodt, David Rasicci, Jeffrey R. Moore, Christopher M. Yengo, Esther Bullitt, William Lehman
Publikováno v:
Journal of General Physiology. 155
During force-generating steps of the muscle crossbridge cycle, the tip of the myosin motor, specifically loop-4, contacts the tropomyosin cable of actin filaments. In the current study, we determined the corresponding effect of myosin loop-4 on the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27195f87c903ace2e2bf94b595b53c11
https://doi.org/10.1085/jgp.202213274
https://doi.org/10.1085/jgp.202213274
The role of myosin loop-4 in localizing tropomyosin on actin during muscle activation and relaxation
Autor:
Matthew Doran, Michael J. Rynkiewicz, Elumalai Pavadai, Skylar M.L. Bodt, Dave Rasicci, Jeffrey R. Moore, Esther Bullitt, Christopher M. Yengo, William Lehman
Publikováno v:
Biophysical Journal. 122:401a-402a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9e5d937669a6cb2b4f67442a610c294
https://doi.org/10.1016/j.bpj.2022.11.2189
https://doi.org/10.1016/j.bpj.2022.11.2189