Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Michael J. Reddish"'
Publikováno v:
J Biol Chem
Human cytochrome P450 (P450) 11B2 catalyzes the formation of aldosterone, the major endogenous human mineralocorticoid. Aldosterone is important for the regulation of electrolyte homeostasis. Mutations and overexpression of P450 11B2 (also known as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802b9a83883896060e1073170a3c4055
https://doi.org/10.1074/jbc.ra119.009830
https://doi.org/10.1074/jbc.ra119.009830
Publikováno v:
Journal of Biological Chemistry. 294:10028-10041
Cytochrome P450 (P450, CYP) enzymes are the major catalysts involved in the oxidation of steroids as well as many other compounds. Their versatility has been explained in part by flexibility of the proteins and complexity of the binding mechanisms. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b640690802aded44594e1e29963f492c
https://doi.org/10.1074/jbc.ra119.008860
https://doi.org/10.1074/jbc.ra119.008860
Autor:
Michael J. Reddish, Leah C. Williams
Publikováno v:
Journal of Chemical Education. 95:928-938
Many chemistry laboratory exercises follow a given protocol with known results. Such traditional laboratories rarely give students an accurate representation of how research is conducted, the scientific practices involved in research, and the ownersh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::076af7448d78a27c3a4d250c58386063
https://doi.org/10.1021/acs.jchemed.7b00855
https://doi.org/10.1021/acs.jchemed.7b00855
Publikováno v:
Biophysical Journal. 112:1852-1862
Enzymes are known to exhibit conformational flexibility. An important consequence of this flexibility is that the same enzyme reaction can occur via multiple reaction pathways on a reaction landscape. A model enzyme for the study of reaction landscap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c389b7c7cf0c262d5c0dd086a0e0c268
https://doi.org/10.1016/j.bpj.2017.03.031
https://doi.org/10.1016/j.bpj.2017.03.031
Autor:
Clayton J. Wilkey, Sarah M. Glass, F. Peter Guengerich, Michael J. Reddish, Donald F. Stec, Stella A. Child
Publikováno v:
J Steroid Biochem Mol Biol
Cytochrome P450 (P450) 11B1 and 11B2 both catalyze the 11β-hydroxylation of 11-deoxycorticosterone and the subsequent 18-hydroxylation of the product. P450 11B2, but not P450 11B1, catalyzes a further C-18 oxidation to yield aldosterone. 11-Oxygenat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b406c2af4d6bc66021411f63cbdbdd4
https://doi.org/10.1016/j.jsbmb.2020.105787
https://doi.org/10.1016/j.jsbmb.2020.105787
Publikováno v:
Biochemistry. 55:1485-1493
Enzymes are known to change among several conformational states during turnover. The role of such dynamic structural changes in catalysis is not fully understood. The influence of dynamics in catalysis can be inferred, but not proven, by comparison o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195c5c00d8992d47c185a3f24ae6c811
https://doi.org/10.1021/acs.biochem.5b01364
https://doi.org/10.1021/acs.biochem.5b01364
Autor:
Ian R. Barckhausen, F. Peter Guengerich, Michael J. Reddish, Margo H. Goldfarb, Sarah M. Glass, Stella A. Child
Publikováno v:
Arch Biochem Biophys
Seven of the 57 human cytochrome P450 (P450) enzymes are mitochondrial and carry out important reactions with steroids and vitamins A and D. These seven P450s utilize an electron transport chain that includes NADPH, NADPH-adrenodoxin reductase (AdR),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b2066f9f18b4648214d5a6af48d4d7
https://doi.org/10.1016/j.abb.2020.108596
https://doi.org/10.1016/j.abb.2020.108596
Publikováno v:
Catalysis in Chemistry and Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbc7ad5a8e18be3f4ae56ad44bfbddea
https://doi.org/10.1142/9789813237179_0043
https://doi.org/10.1142/9789813237179_0043
Publikováno v:
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 178
Time-resolved temperature-jump (T-jump) coupled with fluorescence and infrared (IR) spectroscopy is a powerful technique for monitoring protein dynamics. Although IR spectroscopy of the polypeptide amide I mode is more technically challenging, it off
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3ef74e4650d9a1af5115bc76eb7ebd
https://pubmed.ncbi.nlm.nih.gov/28189834
https://pubmed.ncbi.nlm.nih.gov/28189834
Publikováno v:
Biochemistry. 50:458-465
Genetic instability is determined not only by exogenous factors but also by the properties of DNA itself (1, 2). Such inherent mutagenicity was established through association of fragile X syndrome, spinal and bulbar muscular atrophy, and myotonic dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760e29d8c11982596de5b58994b99d0d
https://doi.org/10.1021/bi101756e
https://doi.org/10.1021/bi101756e