Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Michael J. ROWAN"'
Autor:
Zhengtao Hu, Pengpeng Yu, Yangyang Zhang, Yin Yang, Manyi Zhu, Shuangying Qin, Ji-Tian Xu, Dongxiao Duan, Yong Wu, Deguo Wang, Michael J. Rowan, Neng-Wei Hu
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Soluble amyloid-β-protein (Aβ) oligomers, a major hallmark of AD, trigger the integrated stress response (ISR) via multiple pathologies including neuronal hyperactivation, microvascular hypoxia, and neuroinflammation. Increasing eIF2α pho
Externí odkaz:
https://doaj.org/article/800bf20ce0ae46ac9292771104346e06
Autor:
Tomas Ondrejcak, Neng-Wei Hu, Yingjie Qi, Igor Klyubin, Grant T. Corbett, Graham Fraser, Michael S. Perkinton, Dominic M. Walsh, Andrew Billinton, Michael J. Rowan
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 582-590 (2019)
Soluble synaptotoxic aggregates of the main pathological proteins of Alzheimer's disease, amyloid β-protein (Aß) and tau, have rapid and potent inhibitory effects on long-term potentiation (LTP). Although the promotion of synaptic weakening mechani
Externí odkaz:
https://doaj.org/article/ff95f3803853489a8ff9a0588ee8803a
Publikováno v:
Neurobiology of Disease, Vol 114, Iss , Pp 24-30 (2018)
Pro-inflammatory mechanisms have recently emerged as an important component of early Alzheimer's disease (AD) pathogenesis. A particularly attractive therapeutic strategy is to selectively prevent the disruptive effects of activation of the innate im
Externí odkaz:
https://doaj.org/article/9d560ffd3087414691f84aa7f508e378
Publikováno v:
Cell Reports, Vol 22, Iss 8, Pp 2053-2065 (2018)
Summary: Promotion of long-term depression (LTD) mechanisms by synaptotoxic soluble oligomers of amyloid-β (Aß) has been proposed to underlie synaptic dysfunction in Alzheimer’s disease (AD). Previously, LTD was induced by relatively non-specific
Externí odkaz:
https://doaj.org/article/db63ff2ac5b94a9bbb1113ccfef06acf
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
How endogenously produced soluble amyloid ß-protein (Aß) affects synaptic plasticity in vulnerable circuits should provide insight into early Alzheimer’s disease pathophysiology. McGill-R-Thy1-APP transgenic rats, modeling Alzheimer’s disease a
Externí odkaz:
https://doaj.org/article/af9f4d8afc5844dc879ec920be994be1
Autor:
Yangyang, Zhang, Yin, Yang, Zhengtao, Hu, Manyi, Zhu, Shuangying, Qin, Pengpeng, Yu, Bo, Li, Jitian, Xu, Tomas, Ondrejcak, Igor, Klyubin, Michael J, Rowan, Neng-Wei, Hu
Publikováno v:
Journal of Alzheimer's Disease. 89:335-350
Background: Cognitive decline in Alzheimer’s disease (AD) correlates with the extent of tau pathology, in particular tau hyperphosphorylation, which is strongly age-associated. Although elevation of cerebrospinal fluid or blood levels of phosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca018623833782f9ebc426179af0644
https://doi.org/10.3233/jad-220351
https://doi.org/10.3233/jad-220351
Publikováno v:
Neuropsychopharmacology
Synaptic dysfunction is a likely proximate cause of subtle cognitive impairment in early Alzheimer’s disease. Soluble oligomers are the most synaptotoxic forms of amyloid ß-protein (Aß) and mediate synaptic plasticity disruption in Alzheimer’s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a88165ae1ac26b00fcf699d5292e76
http://europepmc.org/articles/PMC8505492
http://europepmc.org/articles/PMC8505492
Autor:
Yangyang Zhang, Yin Yang, Zhengtao Hu, Manyi Zhu, Shuangying Qin, Pengpeng Yu, Bo Li, Jitian Xu, Michael J. Rowan, Neng-Wei Hu
The progressive cognitive decline in Alzheimer’s disease (AD) patients correlates with the extent of tau pathology, in particular tau hyperphosphorylation, which is strongly age-associated. Although elevation of phosphorylated tau (p-Tau) on residu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::684f68e4afd334effd40c787081bb967
https://doi.org/10.1101/2022.03.28.486022
https://doi.org/10.1101/2022.03.28.486022
Autor:
Zhengtao, Hu, Tomas, Ondrejcak, Pengpeng, Yu, Yangyang, Zhang, Yin, Yang, Igor, Klyubin, Sean P, Kennelly, Michael J, Rowan, Neng-Wei, Hu
Publikováno v:
Neural Regeneration Research. 18:1213
Cognitive decline in Alzheimer's disease correlates with the extent of tau pathology, in particular tau hyperphosphorylation that initially appears in the transentorhinal and related regions of the brain including the hippocampus. Recent evidence ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64aac2be935d8560443577b385255676
https://doi.org/10.4103/1673-5374.360166
https://doi.org/10.4103/1673-5374.360166
Autor:
Shane Foley, Karl Ewins, Peter J. MacMahon, Fionnuala NiAinle, Ciara Gillespie, Michael J. Rowan
Publikováno v:
Thrombosis Research. 177:172-179
Background CTPA is the gold standard investigation for evaluating suspected pulmonary embolism (PE) in the general population however is sometimes considered second line in pregnant and post-partum patients with a normal CXR due to its higher breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735a948112a5ba211478f42d9aecf58a
https://doi.org/10.1016/j.thromres.2019.03.007
https://doi.org/10.1016/j.thromres.2019.03.007