Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Michael J. Prinsen"'
Autor:
Jeannine Basta, Lynn Robbins, Lisa Stout, Michael J. Prinsen, David W. Griggs, Michael Rauchman
Publikováno v:
Physiological Reports, Vol 8, Iss 7, Pp n/a-n/a (2020)
Abstract Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD). Arginine–glycine–aspartic acid (RGD)‐binding integrins are important mediators of the pro‐fibrotic response by activating latent TGF‐β
Externí odkaz:
https://doaj.org/article/d341b803727d47eb838a4fef44f6b15e
Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in MiceSummary
Autor:
Barbara Ulmasov, Brent A. Neuschwander-Tetri, Jinping Lai, Vladimir Monastyrskiy, Trisha Bhat, Matthew P. Yates, Jonathan Oliva, Michael J. Prinsen, Peter G. Ruminski, David W. Griggs
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 4, Pp 499-518 (2016)
Background & Aims: Pancreatic stellate cells (PSCs) regulate the development of chronic pancreatitis (CP) and are activated by the cytokine transforming growth factor β (TGFB). Integrins of the αv family promote TGFB signaling in mice, probably
Externí odkaz:
https://doaj.org/article/9a6d1c0077404b55915eba3b895e7df1
Autor:
Monique R Heitmeier, Richard C Hresko, Rachel L Edwards, Michael J Prinsen, Ma Xenia G Ilagan, Audrey R Odom John, Paul W Hruz
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216457 (2019)
Although the Plasmodium falciparum hexose transporter PfHT has emerged as a promising target for anti-malarial therapy, previously identified small-molecule inhibitors have lacked promising drug-like structural features necessary for development as c
Externí odkaz:
https://doaj.org/article/5b482186f44d47e980b0f7cc11450eff
Autor:
Leah Gehrs, Dwight M. Morrow, David W. Griggs, Stephanie Christ, Andreas Trumpp, Richard F. Heier, Eliza Wiercinska, Halvard Bonig, Moses O. Evbuomwan, Darja Karpova, Peter G. Ruminski, Julie Ritchey, Michael P. Rettig, Feng Gao, Daniel Cancilla, Ezhilarasi Chendamarai, Michael J. Prinsen, Hamza Celik, Grazia Abou-Ezzi, Daniel C. Link, John F. DiPersio, Marvin J. Meyers, Wei Yang, Stacy D. Arnett, Jingzhu Zhang, Matthew Holt, Linda Eissenberg
Publikováno v:
Journal of Clinical Investigation. 129:2745-2759
Mobilized peripheral blood has become the primary source of hematopoietic stem and progenitor cells (HSPCs) for stem cell transplantation, with a 5-day course of granulocyte colony-stimulating factor (G-CSF) as the most common regimen used for HSPC m
Autor:
Lynn Robbins, Michael Rauchman, Michael J. Prinsen, Jeannine Basta, David W. Griggs, Lisa Stout
Publikováno v:
Physiological Reports
Physiological Reports, Vol 8, Iss 7, Pp n/a-n/a (2020)
Physiological Reports, Vol 8, Iss 7, Pp n/a-n/a (2020)
Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD). Arginine–glycine–aspartic acid (RGD)‐binding integrins are important mediators of the pro‐fibrotic response by activating latent TGF‐β at sites
Autor:
Ma. Xenia G. Ilagan, Michael J. Prinsen, Richard C. Hresko, Audrey R. Odom John, Paul W. Hruz, Monique R. Heitmeier, Rachel L. Edwards
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0216457 (2019)
PLoS ONE, Vol 14, Iss 5, p e0216457 (2019)
Although the Plasmodium falciparum hexose transporter PfHT has emerged as a promising target for anti-malarial therapy, previously identified small-molecule inhibitors have lacked promising drug-like structural features necessary for development as c
Autor:
Ying Yu, Brian R. Bond, Jonathan Oliva, Georg Neckermann, Deena Tajfirouz, Marvin J. Meyers, Mary Campbell, Michael J. Prinsen, Stacy D. Arnett, Robert K. M. Choy, Peter G. Ruminski, Yuhua Ji, Eugenio L. de Hostos, David W. Griggs
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Racecadotril (acetorphan) is a neutral endopeptidase (NEP) inhibitor with known antidiarrheal activity in animals and humans; however, in humans, it suffers from shortcomings that might be improved with newer drugs in this class that have progressed
Autor:
Martin Hegen, David C. Wood, Patrik Rhönnstad, Felix Vajdos, Atli Thorarensen, Mark E. Schnute, Timothy Braden, Kimberly Crouse, Maria Sjöberg, John I. Trujillo, Ravi G. Kurumbail, Bolette Husman, Konrad F. Koehler, Mattias Wennerstål, Tomas Bonn, Joakim Löfstedt, Eva Backström-Rydin, Bo Carlsson, Aron Sundell, Ming Z. Chen, Steven E. Heasley, John David Trzupek, Annika Goos-Nilsson, Carol A. Menard, Peter Harris, James R. Kiefer, Martin Bengtsson, Leon P. Collis, Michael J. Prinsen, Philippe Nuhant, Jennifer Alley, Scott A. Long, Alexander E. Hromockyj, Andrew C. Flick, Johnny Sandberg, Christoph W. Zapf, Edouard Zamaratski, Xiao Hu, Lee Napierata, Björn Kauppi, Nicole Caspers, Kimberly F. Fennell, Robert E. Kyne, Gabriel Berstein, Neelu Kaila, Lars Kruger, Wei Li, Li Xing, Ray Unwalla, Elisabet Kallin, Matthew J. Pelc, Susan Fish, James Robert Blinn, Hjalmar Gullberg, Marvin J. Meyers, Scot Richard Mente, Chulho Choi, Falgun Shah, Mathias Färnegårdh, Dean Messing, Peter G. Jones, Yajuan Zhao, Alexandria P. Taylor, Maria Sandström, Charles W. Bolten, Daniel Nöteberg, Robin A. Weinberg, Tomasz Janosik, John D. Knafels, Anna Wilhelmsson
Publikováno v:
Journal of medicinal chemistry. 61(23)
The nuclear hormone receptor retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) is a promising target for the treatment of autoimmune diseases. A small molecule, inverse agonist of the receptor is anticipated to reduce production
Autor:
Stephanie Christ, Michael P. Rettig, Haresh Thakellapalli, Ezhilarasi Chendamarai, Dwight M. Morrow, John F. DiPersio, Daniel Cancilla, Peter G. Ruminski, Darja Karpova, Julie Ritchey, Michael J. Prinsen, Marvin J. Meyers
Publikováno v:
Blood. 134:1916-1916
Background: Hematopoietic stem cell (HSC) transplant is an essential treatment for a variety of blood disorders and malignancies. A key step in this procedure is the mobilization of donor stem cells. The most commonly used regimen for donor mobilizat
Autor:
Christopher S. Eickhoff, Jonathan Oliva, Zhengchao Tu, Daniel E. Goldberg, Xiaorong Liu, David W. Griggs, Megh Singh, Marvin J. Meyers, Francis M. Sverdrup, Limei Qin, Jing Xu, Elizabeth J. Anderson, Michael J. Prinsen, Xiaoping Chen, Wanwan Xu, Peter G. Ruminski, Li Qin, Ke Ding, Stacy D. Arnett, Wentian Zeng, Thomas M. Krenning, Mary Campbell, Siting Zhao, Sarah A. McNitt, Micky D. Tortorella
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:5144-5150
Given the rise of parasite resistance to all currently used antimalarial drugs, the identification of novel chemotypes with unique mechanisms of action is of paramount importance. Since Plasmodium expresses a number of aspartic proteases necessary fo