Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Michael J. Powling"'
Autor:
Stephen J. Holland, Paul V. Fish, John P. Overington, Keith James, Stuart M. Abel, Michael J. Powling, David J. Rance, Andrew B. McElroy, Edward Hawkeswood, Alan Daniel Brown, John C. Danilewicz
Publikováno v:
Journal of medicinal chemistry. 45(12)
Potent and selective inhibitors of thrombin were sought based on the (R)-Phe-Pro-Arg sequence. The objective was to generate similar binding interactions to those achieved by potent competitive inhibitors of the argatroban type, so eliminating the ne
Autor:
Roger M. Hardisty, Michael J. Powling
Publikováno v:
Blood. 66:731-734
Changes in intracellular Ca2+ concentrations [( Ca2+]i) in platelets stimulated with aggregating agents were measured with the fluorescent indicator dye quin 2. Ca2+ influx, but not intracellular mobilization, in response to adenosine diphosphate (AD