Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Michael J. Pokrass"'
Autor:
Michael J. Pokrass, Sergi Regot
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100446- (2021)
Summary: Determining how signaling dynamics relate to gene expression and cell fate is essential to understanding multicellular development. We present a unified live imaging and lineage analysis method that allows integrated analysis of both techniq
Externí odkaz:
https://doaj.org/article/cf6dea0e20364b6881ea17b299ec4161
Publikováno v:
eLife, Vol 9 (2020)
A large fraction of human cancers contain genetic alterations within the Mitogen Activated Protein Kinase (MAPK) signaling network that promote unpredictable phenotypes. Previous studies have shown that the temporal patterns of MAPK activity (i.e. si
Externí odkaz:
https://doaj.org/article/fb4b9c60b8f043069e467879fa0fa195
Autor:
Valentina Greco, Winston Timp, Michael J. Pokrass, Tianchi Xin, Sergi Regot, Kathleen A. Ryan, Brittany Pielstick
Publikováno v:
Dev Cell
Despite the noisy nature of single cells, multicellular organisms robustly generate different cell types from one zygote. This process involves dynamic cross regulation between signaling and gene expression that is difficult to capture with fixed-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ac22ed7d8d7d9dca42ac7fb7a4fee4
https://europepmc.org/articles/PMC7658051/
https://europepmc.org/articles/PMC7658051/
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
A large fraction of human cancers contain genetic alterations within the Mitogen Activated Protein Kinase (MAPK) signaling network that promote unpredictable phenotypes. Previous studies have shown that the temporal patterns of MAPK activity (i.e. si
Epithelial tissues are constantly challenged by individual cell fate decisions while maintaining barrier function. During oncogenesis, mutant and normal cells also differ in their signaling states and cellular behaviors creating competitive interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8584acfb0701d0926980020178daac61
Publikováno v:
Expert Opinion on Therapeutic Targets. :1-16
Sigma-1 receptors (Sig-1Rs) are molecular chaperones that reside mainly in the endoplasmic reticulum (ER) but exist also in the proximity of the plasma membrane. Sig-1Rs are highly expressed in the CNS and are involved in many cellular processes incl
Publikováno v:
Molecular Immunology. 56:549-560
β2-Microglobulin (β2M), the light chain of the class I major histocompatibilty complex (MHC-I), is a promising tumor target for monoclonal antibodies (mAbs) in cancer immunotherapy. Several reports indicate that chelation of cell-associated β2M by
Autor:
Yunhua Zhu, Dennisse Jimenez-Cyrus, Yijing Su, Xiaoxi Zhuang, Namshik Kim, Chuan He, Stefan Canzar, Caroline Vissers, Ki Jun Yoon, Fadi Jacob, Francisca Rojas Ringeling, Michael J. Pokrass, Peng Jin, Guo Li Ming, Xinyuan Wang, Lily Zheng, Sergi Regot, Sunghan Kim, Hongjun Song, Louis C. Dore
Publikováno v:
Cell. 171:877-889.e17
N6-methyladenosine (m6A), installed by the Mettl3/Mettl14 methyltransferase complex, is the most prevalent internal mRNA modification. Whether m6A regulates mammalian brain development is unknown. Here, we show that m6A depletion by Mettl14 knockout
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(21)
Dysregulation of cyclin-dependent kinase 5 (cdk5) per relative concentrations of its activators p35 and p25 is implicated in neurodegenerative diseases. P35 has a short t½ and undergoes rapid proteasomal degradation in its membrane-bound myristoylat