Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michael J. Petrany"'
Autor:
Chengyi Sun, Casey O. Swoboda, Fabian Montecino Morales, Cristofer Calvo, Michael J. Petrany, Sreeja Parameswaran, Andrew VonHandorf, Matthew T. Weirauch, Christoph Lepper, Douglas P. Millay
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Multinucleated skeletal muscle cells need to acquire additional nuclei through fusion with activated skeletal muscle stem cells when responding to both developmental and adaptive growth stimuli. A fundamental question in skeletal muscle biol
Externí odkaz:
https://doaj.org/article/8c56113a1c204bb3a256923ff6709e46
Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
Autor:
Michael J. Petrany, Casey O. Swoboda, Chengyi Sun, Kashish Chetal, Xiaoting Chen, Matthew T. Weirauch, Nathan Salomonis, Douglas P. Millay
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mammalian skeletal muscle is composed of multinucleated myofibers, containing hundreds of nuclei that coordinate cellular function. Here, the authors show that single-nucleus RNA-sequencing reveals rare and emergent myonuclear populations, and uncove
Externí odkaz:
https://doaj.org/article/b1bd009b492847ec94ecd25cf3c44bce
Autor:
Malgorzata E. Quinn, Qingnian Goh, Mitsutoshi Kurosaka, Dilani G. Gamage, Michael J. Petrany, Vikram Prasad, Douglas P. Millay
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Cellular fusion is fundamental for skeletal muscle development. Here the authors show that myomerger is expressed in myoblasts, is essential for myoblast fusion in mice, and in co-operation with myomaker confers fusogenic ability to non-fusogenic cel
Externí odkaz:
https://doaj.org/article/f9517f4aa0cf41ccb0945886204443b1
Autor:
Qingnian Goh, Taejeong Song, Michael J Petrany, Alyssa AW Cramer, Chengyi Sun, Sakthivel Sadayappan, Se-Jin Lee, Douglas P Millay
Publikováno v:
eLife, Vol 8 (2019)
Skeletal muscle adapts to external stimuli such as increased work. Muscle progenitors (MPs) control muscle repair due to severe damage, but the role of MP fusion and associated myonuclear accretion during exercise are unclear. While we previously dem
Externí odkaz:
https://doaj.org/article/32252ed41c0047a7acc1c6efd07a3e85
Autor:
Sajedah M. Hindi, Michael J. Petrany, Elena Greenfeld, Leah C. Focke, Alyssa A.W. Cramer, Michael A. Whitt, Vikram Prasad, Jeffrey S. Chamberlain, Benjamin Podbilewicz, Douglas P. Millay
Publikováno v:
bioRxiv
SummaryEntry of enveloped viruses into cells is mediated by fusogenic proteins that form a complex between membranes to drive rearrangements needed for fusion. Skeletal muscle development also requires membrane fusion events between progenitor cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b91a4a4ddb2a88c9938b3657a89b83
https://europepmc.org/articles/PMC10055243/
https://europepmc.org/articles/PMC10055243/
Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
Autor:
Casey O. Swoboda, Matthew T. Weirauch, Douglas P. Millay, Kashish Chetal, Nathan Salomonis, Xiaoting Chen, Michael J. Petrany, Chengyi Sun
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
While the majority of cells contain a single nucleus, cell types such as trophoblasts, osteoclasts, and skeletal myofibers require multinucleation. One advantage of multinucleation can be the assignment of distinct functions to different nuclei, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adce0d99c5b4874550dc542ae075eef3
https://doaj.org/article/b1bd009b492847ec94ecd25cf3c44bce
https://doaj.org/article/b1bd009b492847ec94ecd25cf3c44bce
Autor:
Michael J. Petrany, Douglas P. Millay
Publikováno v:
Trends Cell Biol
Cell fusion is essential for the development of multicellular organisms, and plays a key role in the formation of various cell types and tissues. Recent findings have highlighted the varied protein machinery that drives plasma-membrane merger in diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4573d7c96724dc6a62f58eb58fd5f4
https://doi.org/10.1016/j.tcb.2019.09.002
https://doi.org/10.1016/j.tcb.2019.09.002
Publikováno v:
JCI Insight
Muscle progenitor cell fusion is required for the formation and regeneration of multinucleated skeletal muscle fibers. Chronic muscle regeneration in Duchenne muscular dystrophy (DMD) is characterized by ongoing fusion of satellite cell (SC) progeny,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62f61d0b9d2074f8ba8a4c65eadb223
https://doi.org/10.1172/jci.insight.136095
https://doi.org/10.1172/jci.insight.136095
Autor:
Douglas P. Millay, Qingnian Goh, Se-Jin Lee, Michael J. Petrany, Taejeong Song, Chengyi Sun, Alyssa A. W. Cramer, Sakthivel Sadayappan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1db4c84bde5b2c7b82482a522cb5857
https://doi.org/10.7554/elife.44876.015
https://doi.org/10.7554/elife.44876.015
Autor:
Chengyi Sun, Se-Jin Lee, Qingnian Goh, Alyssa A. W. Cramer, Taejeong Song, Sakthivel Sadayappan, Michael J. Petrany, Douglas P. Millay
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Skeletal muscle adapts to external stimuli such as increased work. Muscle progenitors (MPs) control muscle repair due to severe damage, but the role of MP fusion and associated myonuclear accretion during exercise are unclear. While we previously dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72486b3a2cdbcee0b4cf40f560fe8c87
https://elifesciences.org/articles/44876
https://elifesciences.org/articles/44876