Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Michael J. P. Arthur"'
Publikováno v:
Journal of gastroenterology and hepatology. 13(S1)
Hepatic stellate cells (HSC) play a central role in the pathogenesis of liver fibrosis. Following liver injury, these cells proliferate and are activated to a profibrogenic myofibroblastic phenotype. In addition to increased matrix protein synthesis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349b9e4fc3dd32fe1898aa39fc956062
https://pubmed.ncbi.nlm.nih.gov/28976699
https://pubmed.ncbi.nlm.nih.gov/28976699
Autor:
John P. Iredale, Hideaki Nagase, Frank Murphy, Razao Issa, Xiaoying Zhou, Michael J. P. Arthur, Christopher Benyon, Shabna Ratnarajah
Publikováno v:
Journal of Biological Chemistry. 277:11069-11076
The activated hepatic stellate cell (HSC) is central to liver fibrosis as the major source of collagens I and III and the tissue inhibitors of metalloproteinase-1 (TIMP-1). During spontaneous recovery from liver fibrosis, there is a decrease of TIMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b67287f47d91feebe6401e7caced6ec7
https://doi.org/10.1074/jbc.m111490200
https://doi.org/10.1074/jbc.m111490200
Autor:
Mark Harris, Derek A. Mann, David E. Smart, Frank Murphy, Christopher McCormick, Runping Gao, Fiona Oakley, Richard Ruddell, Michael J. P. Arthur
Publikováno v:
Liver. 22:15-22
Background/aims: Gene transfer into hepatic stellate cells (HSC) is inefficient when using plasmid-based transfection methods; viral-based systems are therefore being developed. A baculovirus system has recently been shown to be useful for expressing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aec574abfb989524519344b7621a513a
https://doi.org/10.1046/j.0106-9543.2001.01555.x
https://doi.org/10.1046/j.0106-9543.2001.01555.x
Autor:
Finn Larsen, Robert Sutton, Michael J. P. Arthur, Cornel C. Sieber, Daniel Grandt, Peter Schiedermaier, Phillip Harrison, Jürgen Drewe
Publikováno v:
Digestion. 65:56-60
Background: Lanreotide, a new long-acting somatostatin analogue, has been shown to inhibit the meal-stimulated increase of splanchnic blood flow in healthy volunteers. To date, similar data in patients with liver cirrhosis have not been available. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53338489827e1ee913e007cf4f5ff38f
https://doi.org/10.1159/000051932
https://doi.org/10.1159/000051932
Autor:
Julie E. Trim, David E. Smart, Karen J. Vincent, Michael J. P. Arthur, Erick C. Jones, Matthew C. Wright, Derek A. Mann
Publikováno v:
Gut. 49:713-719
BACKGROUND—Activation of hepatic stellate cells (HSCs) to a myofibroblastic phenotype is a key event in liver fibrosis. Identification of transcription factors with activities that are modulated during HSC activation will improve our understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd11bb4b831becb84cdd8edc612cc01
https://doi.org/10.1136/gut.49.5.713
https://doi.org/10.1136/gut.49.5.713
Autor:
Elizabeth J. Williams, B H Grove, RC Benyon, John P. Iredale, E N Unemori, Michael J. P. Arthur, R Hadwin, Nathan Trim
Publikováno v:
Gut. 49:577-583
BACKGROUND—Following liver injury, hepatic stellate cells (HSC) transform into myofibroblast-like cells (activation) and are the major source of type I collagen and the potent collagenase inhibitors tissue inhibitors of metalloproteinases 1 and 2 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ceba680f1a2659eb68b134c842c5643
https://doi.org/10.1136/gut.49.4.577
https://doi.org/10.1136/gut.49.4.577
Autor:
David E. Smart, Jelena Mann, Oliver Eickelberg, Marc Castellazzi, Karen J. Vincent, Michael J. P. Arthur, Derek A. Mann
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, 2001, 276, pp.24414-24421
Journal of Biological Chemistry, 2001, 276, pp.24414-24421
Activation of hepatic stellate cells (HSCs) to a myofibroblast-like phenotype is the pivotal event in hepatic wound healing and fibrosis. Rat HSCs activated in vitro express JunD, Fra2, and FosB as the predominant AP-1 DNA-binding proteins, and all t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbf8c28c4b5263134c6d9deec37c316
https://doi.org/10.1074/jbc.m101840200
https://doi.org/10.1074/jbc.m101840200
Autor:
Michael J. P. Arthur
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 279:G245-G249
Liver fibrosis is characterized by activation of hepatic stellate cells, which are then involved in synthesis of matrix proteins and in regulating matrix degradation. In the acute phases of liver injury and as liver fibrosis progresses, there is incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cda7f9dd6dd02654d882865ca93e831
https://doi.org/10.1152/ajpgi.2000.279.2.g245
https://doi.org/10.1152/ajpgi.2000.279.2.g245
Autor:
David R. Brigstock, Marianna D. A. Gaça, Elizabeth J. Williams, Michael J. P. Arthur, R. Christopher Benyon
Publikováno v:
Journal of Hepatology. 32:754-761
Background/Aims: Connective tissue growth factor is a recently described mitogenic protein implicated in a variety of fibrotic disorders. Connective tissue growth factor may be a downstream mediator of the pro-fibrotic and mitogenic actions of transf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d00f57bb0a40516ad8da69dbbb56ed
https://doi.org/10.1016/s0168-8278(00)80244-5
https://doi.org/10.1016/s0168-8278(00)80244-5
Autor:
John P. Iredale, R. Christopher Benyon, Christopher J. Hovell, Marianna D. A. Gaça, Michael J. P. Arthur, Emma H. Jones
Publikováno v:
Hepatology. 30:977-986
Activated hepatic stellate cells (HSCs) are a potential source of gelatinase A, which accumulates in fibrotic livers. Progelatinase A activation requires its binding to a complex of membrane-type matrix metalloproteinase (MT-MMP) and tissue inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8cf2cc1b1a67e83f311849313cd0b7a
https://doi.org/10.1002/hep.510300431
https://doi.org/10.1002/hep.510300431